全文获取类型
收费全文 | 2358篇 |
免费 | 133篇 |
国内免费 | 26篇 |
专业分类
耳鼻咽喉 | 14篇 |
儿科学 | 80篇 |
妇产科学 | 18篇 |
基础医学 | 378篇 |
口腔科学 | 34篇 |
临床医学 | 147篇 |
内科学 | 534篇 |
皮肤病学 | 50篇 |
神经病学 | 223篇 |
特种医学 | 103篇 |
外科学 | 481篇 |
综合类 | 9篇 |
预防医学 | 53篇 |
眼科学 | 19篇 |
药学 | 129篇 |
中国医学 | 2篇 |
肿瘤学 | 243篇 |
出版年
2023年 | 17篇 |
2022年 | 25篇 |
2021年 | 46篇 |
2020年 | 23篇 |
2019年 | 51篇 |
2018年 | 50篇 |
2017年 | 36篇 |
2016年 | 46篇 |
2015年 | 52篇 |
2014年 | 66篇 |
2013年 | 91篇 |
2012年 | 142篇 |
2011年 | 144篇 |
2010年 | 82篇 |
2009年 | 82篇 |
2008年 | 138篇 |
2007年 | 144篇 |
2006年 | 152篇 |
2005年 | 181篇 |
2004年 | 146篇 |
2003年 | 165篇 |
2002年 | 150篇 |
2001年 | 21篇 |
2000年 | 21篇 |
1999年 | 29篇 |
1998年 | 54篇 |
1997年 | 49篇 |
1996年 | 28篇 |
1995年 | 21篇 |
1994年 | 19篇 |
1993年 | 32篇 |
1992年 | 19篇 |
1991年 | 15篇 |
1990年 | 20篇 |
1989年 | 13篇 |
1988年 | 9篇 |
1987年 | 10篇 |
1986年 | 6篇 |
1985年 | 7篇 |
1984年 | 18篇 |
1983年 | 13篇 |
1982年 | 11篇 |
1981年 | 10篇 |
1980年 | 5篇 |
1979年 | 5篇 |
1978年 | 6篇 |
1977年 | 8篇 |
1973年 | 4篇 |
1970年 | 4篇 |
1965年 | 4篇 |
排序方式: 共有2517条查询结果,搜索用时 31 毫秒
91.
Takatoshi Shigeta Kaoru Okishige Hideshi Aoyagi Takuro Nishimura Rena A. Nakamura Naruhiko Ito Yusuke Tsuchiya Mitsutoshi Asano Tsukasa Shimura Hidetoshi Suzuki Manabu Kurabayashi Yuichi Fukami Shinya Sakita Takehiko Keida Tetsuo Sasano Kenzo Hirao Yasuteru Yamauchi 《Pacing and clinical electrophysiology : PACE》2019,42(2):230-237
92.
To evaluate the significance of inducible sustained ventricular tachycardia (VT) in patients with coronary artery disease and relatively preserved cardiac function, 33 patients who met the following criteria were studied; documented nonsustained VT but no history of life-threatening arrhythmia, inducible sustained VT at electrophysiologic study, and implantation of a cardioverter-defibrillator. Eighteen patients developed clinical sustained VT within 2 years. By univariate analysis, left ventricular ejection fraction (EF) and the cycle length of induced VT were associated with clinical VT occurrence. By multivariate analysis, however, EF was the only independent predictor. Among 23 patients with EF 40% (P <.01). In coronary artery disease patients with relatively preserved EF, the incidence of clinical VT is considerably low even though sustained VT is inducible. Inducible VT is therefore not appropriate for risk stratification in this patient population. 相似文献
93.
Ohura T Sanada H Mino Y 《Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics》2004,41(1):82-91
In recent years, the concept of cost-effectiveness, including medical delivery and health service fee systems, has become widespread in Japanese health care. In the field of pressure ulcer management, the recent introduction of penalty subtraction in the care fee system emphasizes the need for prevention and cost-effective care of pressure ulcer. Previous cost-effectiveness research on pressure ulcer management tended to focus only on "hardware" costs such as those for pharmaceuticals and medical supplies, while neglecting other cost aspects, particularly those involving the cost of labor. Thus, cost-effectiveness in pressure ulcer care has not yet been fully established. To provide true cost effectiveness data, a comparative prospective study was initiated in patients with stage II and III pressure ulcers. Considering the potential impact of the pressure reduction mattress on clinical outcome, in particular, the same type of pressure reduction mattresses are utilized in all the cases in the study. The cost analysis method used was Activity-Based Costing, which measures material and labor cost aspects on a daily basis. A reduction in the Pressure Sore Status Tool (PSST) score was used to measure clinical effectiveness. Patients were divided into three groups based on the treatment method and on the use of a consistent algorithm of wound care: 1. MC/A group, modern dressings with a treatment algorithm (control cohort). 2. TC/A group, traditional care (ointment and gauze) with a treatment algorithm. 3. TC/NA group, traditional care (ointment and gauze) without a treatment algorithm. The results revealed that MC/A is more cost-effective than both TC/A and TC/NA. This suggests that appropriate utilization of modern dressing materials and a pressure ulcer care algorithm would contribute to reducing health care costs, improved clinical results, and, ultimately, greater cost-effectiveness. 相似文献
94.
Kato N Nabika T Liang YQ Mashimo T Inomata H Watanabe T Yanai K Yamori Y Yazaki Y Sasazuki T 《Hypertension》2003,42(6):1191-1197
Recently, a genome-wide screen has shown a major quantitative trait locus (QTL) for a stroke-associated phenotype on rat chromosome 1 (RNO1) independent of QTL for blood pressure (BP) in the stroke-prone spontaneously hypertensive rat (SHRSP) of a Heidelberg colony. However, it remains to be elucidated whether these observations reflect the existence of different genes predisposing to each of the disorders. To address this issue, we performed comprehensive approaches in a Japanese colony, Izm, as follows. First, we undertook genome-wide searches in F1(SHRSP/IzmxWKY/Izm)xSHRSP/Izm back-cross (n=63) to pursue a causal relation between hypertension and stroke. Although the strongest linkage to BP (LOD score of 3.4) was identified on RNO1, its relevance to stroke was not supported in the F1 back-cross studied. Second, we also investigated linkage to BP in F2 progeny (n=175) involving the stroke-resistant (or normal) spontaneously hypertensive rat (SHR). In F2 studies of SHR/Izm, this locus did not appear to constitute a principal BP QTL. Third, we constructed congenic animals with detailed phenotype characterization. Transfer of a chromosomal fragment between markers Klk1 and D1Rat116 from WKY/Izm onto the SHRSP/Izm background lowered systolic BP by 20 to 80 mm Hg, prevented development of apparent stroke, and exaggerated impaired glucose tolerance. In conclusion, we have successfully isolated an RNO1 region affecting BP, stroke, and glucose tolerance in SHRSP/Izm-derived congenic rats. The size of the introgressed region is large, but our novel congenic strain should help delineate complex, genetic impairments underlying BP and associated vascular disease phenotypes. 相似文献
95.
Niizeki T Takeishi Y Arimoto T Okuyama H Takabatake N Tachibana H Nozaki N Hirono O Tsunoda Y Miyashita T Fukui A Takahashi H Koyama Y Shishido T Kubota I 《Journal of cardiology》2005,46(1):9-15
BACKGROUND AND OBJECTIVES: Heart-type fatty acid binding protein (H-FABP) is released into the circulation from the damaged myocardium of patients with severe chronic heart failure. Chronic heart failure is the most frequent cause of death and disability in the elderly. However, there are no data for the prognostic value of H-FABP in the elderly population. This study investigated whether H-FABP can effectively predict the prognosis in elderly patients (> or = 70 years) with chronic heart failure. METHODS: Serum H-FABP levels were measured in 90 chronic heart failure patients > or =70 years old (mean age 77 +/- 4 years, range 70-92 years), and patients were followed-up for 421 +/- 326 days. RESULTS: There were 35 cardiac events (38.9%) including cardiac deaths and readmissions for worsening chronic heart failure. Multivariate analysis with the Cox proportional hazard model showed that H-FABP was the only independent predictor of cardiac events (chi2 = 6.640, p = 0.0100). Kaplan-Meier analysis revealed that H-FABP effectively risk stratified elderly patients with chronic heart failure for cardiac events. CONCLUSIONS: These findings suggest that H-FABP is a reliable marker for prognosis in elderly patients with chronic heart failure. 相似文献
96.
97.
Shinichi Kako Yoshinobu Kanda Makoto Onizuka Nobuyuki Aotsuka Kensuke Usuki Takayoshi Tachibana Takeshi Kobayashi Jun Kato Shingo Yano Hiroaki Shimizu Katsuhiro Shono Masatsugu Tanaka Shokichi Tsukamoto Takehiko Mori Etsuko Yamazaki Yuho Najima Akira Hangaishi Takumi Hoshino Reiko Watanabe Kenji Matsumoto Shinichiro Okamoto for Kanto Study Group for Cell Therapy 《American journal of hematology》2020,95(3):251-257
The optimal pre-transplant conditioning for aplastic anemia (AA) remains unclear. We performed a prospective study on allogeneic transplantation from a related or unrelated donor for adult patients with AA. We assessed whether reduced-dose cyclophosphamide (CY) could decrease toxicity while maintaining engraftment, and low-dose thymoglobulin could safely prevent graft-vs-host disease (GVHD). The pre-transplant conditioning regimen consisted of fludarabine 120 mg/m2, CY 100 mg/kg, and thymoglobulin 2.5 mg/kg with or without 2 Gy of total body irradiation. Twenty-seven patients with a median age of 36 years were analyzed. Sixteen patients received graft from related donors. The stem cell source was bone marrow in 26 patients. All of the patients but one, who died early, achieved neutrophil engraftment at a median of 19 days. Mixed chimerism was observed in six and five patients at days 30 and 90, respectively. Only one patient experienced secondary engraftment failure with complete donor-type chimerism. None of the patients developed severe acute GVHD. The cumulative incidence of chronic GVHD was 37.7% at 1 year. The overall survival rate was 96.3% at 1 year and 3 years. A high EB virus-DNA load was detected in one patient at days 60. No one developed EBV-lymphoproliferative disorder within a year. The results suggest that the conditioning regimen in this study was safe and effective. However, relatively high incidence of chronic GVHD needs further improvement. 相似文献
98.
99.
Hiroki Ito Futoshi Sano Takehiko Ogawa Masahiro Yao 《International journal of urology》2014,21(1):108-112
We investigated the Core Lower Urinary Tract Symptom Score as an outcome assessment tool for the treatment of lower urinary tract symptoms using silodosin. In addition, the ability of the Core Lower Urinary Tract Symptom Score to detect overactive bladder in male patients with lower urinary tract symptoms was examined. The present study included 241 males with benign prostatic hyperplasia treated at 31 medical facilities between June 2009 and December 2010. All patients were given silodosin, and the effects of silodosin intake were measured using four questionnaires: the Core Lower Urinary Tract Symptom Score, International Prostate Symptom Score, Overactive Bladder Symptom Score and Quality‐of‐Life index. The efficacy of silodosin for treating lower urinary tract symptoms was validated according to the total scores of all four questionnaires weighted equally (P < 0.05). Spearman's ρ among the Core Lower Urinary Tract Symptom Score, International Prostate Symptom Score and Overactive Bladder Symptom Score showed a mild‐high correlation. However, the correlation between the baseline values of the Core Lower Urinary Tract Symptom Score and Quality‐of‐Life index was low in the groups with benign prostatic hyperplasia (ρ = 0.314) and benign prostatic hyperplasia/overactive bladder (ρ = 0.244). Our findings showed the Core Lower Urinary Tract Symptom Score, both its total score and each subscore, is able to show the efficacy of silodosin, similar to other questionnaires. The Core Lower Urinary Tract Symptom Score is also useful for identifying overactive bladder symptoms in patients with benign prostatic hyperplasia. As the Core Lower Urinary Tract Symptom Score does not correlate well with the Quality‐of‐Life index, these two questionnaires might be better used in combination to assess treatment outcomes. 相似文献
100.
Takehiko Tsujimoto Toshimi Sairenchi Hiroyasu Iso Fujiko Irie Kazumasa Yamagishi Hiroshi Watanabe Kiyoji Tanaka Takashi Muto Hitoshi Ota 《Journal of epidemiology / Japan Epidemiological Association》2014,24(6):444-451