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81.
Sota Iwafuchi Atsuo Kikuchi Wakaba Endo Takehiko Inui Yu Aihara Kazuhito Satou Tadashi Kaname Shigeo Kure 《Brain & development》2021,43(2):303-307
BackgroundCUL3 encodes cullin-3, a core component of a ubiquitin E3 ligase. CUL3 mutations have recently been associated with autism spectrum disorder (ASD); however, the detailed clinical courses have been described in only a limited number of patients with CUL3 mutations and neurodevelopmental diseases, including ASD.Case reportA 21-month-old Japanese girl presented with febrile status epilepticus and thereafter exhibited developmental regression, including loss of her verbal ability, eye contact, and skills in activities of daily living. Trio-based exome sequencing identified a de novo two-base insertion in CUL3, c.1758_1759insTG, p.(Thr587*).ConclusionWe report a case of a patient with ASD and a stop-gain CUL3 variant. Screening of CUL3 variants is worth considering for patients with ASD, especially those with Rett-like developmental regression. 相似文献
82.
José Roberto Luzzi Claudio C. Borba Sandra C. Miyaji Cristina A. Brito Roberta Navarro-Xavier Carla L. Dinardo 《Transfusion and apheresis science》2021,60(1):103005
RationalTherapeutic Plasma Exchange (TPE) procedures in pediatric patients are challenging due to the large extracorporeal volume of the cell separators, which were designed for adults. Red blood cell (RBC) priming is an alternative for overpassing the risks of hypovolemia, but data referring to the volume of packed RBCs to be infused are yet incomplete. Restricting the volume of RBC priming may potentially be associated with less transfusion reactions.GoalTo determine the safety of administering a reduced volume of RBC priming for pediatric patients undergoing TPE, in comparison to the standard volume recommended by the cell separators’ manufacturers.MethodsThis was a case-control study which enrolled 15 pediatric patients undergoing TPE and weighting more than 10Kg. The TPE procedures (n = 406) were divided in two groups: 1) Group1: TPE with ≤150 mL of packed RBC priming and 2) Group2: TPE with 150-250 mL of RBC priming. Groups were compared in terms of hemoglobin / hematocrit and occurrence of adverse reactions.ResultsGroup1 and Group2 did not differ significantly in relation to pre- and post-TPE hemoglobin (Hb) levels (p = 0.19 and p = 0.18, respectively). The Δ Hb (Hb pre-TPE – Hb post-TPE) was also not statistically different between the groups. The number of adverse reactions was significantly higher in Group 2 in relation to Group 1 (p = 0.01). The number of allergic reactions was also higher in Group 2 (p = 0.06).ConclusionsRestricting the volume of RBC priming to less than 150 mL is safe for pediatric patients weighting more than 10Kg and associated with lower rates of transfusion-related adverse reactions. 相似文献
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Aisa Y Mori T Nakazato T Yamazaki R Yamagami J Amagai M Ikeda Y Okamoto S 《International journal of hematology》2005,82(3):266-269
A 44-year-old woman with refractory follicular lymphoma underwent allogeneic stem cell transplantation (SCT) and achieved
complete remission. Grade III acute graft-versus-host disease (GVHD) developed on day 23, but no chronic GVHD occurred. The
patient developed severe erosion with bullous lesions in the oral cavity 18 months after SCT. At that time, the lymphoma remained
in complete remission, and she had no clinical or laboratory findings suggesting chronic GVHD. A biopsy of the oral mucosa
showed moderate lymphoplasmacytic infiltration and subepidermal bullae, and direct immunofluorescence staining demonstrated
linear deposition of C3 at the dermo-epidermal junction. An immunoblotting assay using human epidermal extracts confirmed
the presence in her serum of an antibody against the 230-kd bullous pemphigoid antigen 1 (BPAG1). A diagnosis of cicatricial
pemphigoid (CP) was made, and complete resolution of the CP was achieved with pred-nisolone therapy. The occurrence of autoimmune
blistering diseases is rare after allogeneic SCT. 相似文献
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Bokun Kim Takehiko Tsujimoto Rina So Xiaoguang Zhao Shun Suzuki Taeho Kim Kiyoji Tanaka 《Journal of Physical Therapy Science》2015,27(12):3787-3791
To prevent or remedy musculoskeletal conditions, the relationship between obesity and the
characteristics of muscle mass and strength need to be clarified. [Subjects and Methods] A
total of 259 Japanese males aged 30–64 years were classified into 4 groups according to
the Japanese obesity criteria. Body composition was evaluated, and handgrip strength and
knee extensor strength were measured for the upper and lower extremities, respectively.
Physical performance was evaluated with a jump test. [Results] Obesity was positively
correlated with skeletal muscle mass index, percentage of whole-body fat, and leg muscle
strength and negatively correlated with the percentage of muscle mass index, body
weight-normalized handgrip strength, and knee extensor strength, and the jump test
results. [Conclusion] Weight loss may be a better approach than increasing muscle mass and
strength to improve musculoskeletal conditions in obese adult males.Key words: Obesity, Muscle mass, Muscle strength 相似文献
88.
Mizuki Hachiya Shin Murata Hiroshi Otao Takehiko Ihara Katsuhiko Mizota Toyoko Asami 《Journal of Physical Therapy Science》2015,27(12):3663-3666
[Purpose] This study aimed to verify the usefulness of a 50-m round walking test
developed as an assessment method for walking ability in the elderly. [Subjects] The
subjects were 166 elderly requiring long-term care individuals (mean age, 80.5 years).
[Methods] In order to evaluate the factors that had affected falls in the subjects in the
previous year, we performed the 50-m round walking test, functional reach test, one-leg
standing test, and 5-m walking test and measured grip strength and quadriceps strength.
[Results] The 50-m round walking test was selected as a variable indicating fall risk
based on the results of multiple logistic regression analysis. The cutoff value of the
50-m round walking test for determining fall risk was 0.66 m/sec. The area under the
receiver operating characteristic curve was 0.64. The sensitivity of the cutoff value was
65.7%, the specificity was 63.6%, the positive predictive value was 55.0%, the negative
predictive value was 73.3%, and the accuracy was 64.5%. [Conclusion] These results suggest
that the 50-m round walking test is a potentially useful parameter for the determination
of fall risk in the elderly requiring long-term care.Key words: 50-meter round walk test, Local elderly individuals, Falls 相似文献
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90.
Hirata N Kushida Y Ohguri T Wakasugi S Kojima T Fujita R 《Journal of gastroenterology》1999,34(6):713-716
We present a patient with complication of huge hepatic subcapsular hematoma after extracorporeal shock wave lithotripsy (ESWL)
for pancreatic lithotripsy. The hematoma measured 78–110 mm. Angiography showed a subcapsular hematoma, rather than a hematoma
in the liver. In the arterial phase, the distal end of the small vessel showed spotty opacification similar to microaneurysma,
suggesting that it was an injury caused by separation of the liver and its capsule, caused by the shock waves. The portal
vein and hepatic vein were normal. After 8 weeks of conservative therapy, the hematoma was gradually absorbed and the patient
was discharged. Eight months after the accident, the hematoma had decreased to 40 mm in size. After 20 months, it was completely
absorbed. The reported rate of renal subcapsular hematoma after ESWL for renal or ureter stones is 0.1%–0.7%. To date, however,
only five cases of hepatic subcapsular hematoma after right renal stone disintegration have been reported. This is the first
report of hepatic subcapsular hematoma after ESWL for pancreatic stones.
Received: September 11, 1998 / Accepted: April 16, 1999 相似文献