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Aliza Hussain Wensheng Sun Anita Deswal James A. de Lemos John W. McEvoy Ron C. Hoogeveen Kunihiro Matsushita David Aguilar Biykem Bozkurt Salim S. Virani Amil M. Shah Elizabeth Selvin Chiadi Ndumule Christie M. Ballantyne Vijay Nambi 《Journal of the American College of Cardiology》2021,77(5):559-571
BackgroundAlthough intensive blood pressure reduction has cardiovascular benefits, the absolute benefit is greater in those at higher cardiovascular disease (CVD) risk.ObjectivesThis study examined whether N-terminal pro–B-type natriuretic peptide (NT-proBNP) helps identify subjects at higher risk for CVD events across systolic blood pressure (SBP), diastolic blood pressure (DBP), or pulse pressure (PP) categories.MethodsParticipants from the ARIC (Atherosclerosis Risk In Communities) study visit 4 (1996 to 98) were grouped according to SBP, DBP, or PP categories and further stratified by NT-proBNP categories. Cox regression models were used to estimate hazard ratios for incident CVD (coronary heart disease, ischemic stroke, or heart failure hospitalization) and mortality across combined NT-proBNP and/or BP categories, adjusting for CVD risk factors.ResultsThere were 9,309 participants (age: 62.6 ± 5.6 years; 58.3% women) with 2,416 CVD events over a median follow-up of 16.7 years. Within each SBP, DBP, or PP category, a higher category of NT-proBNP (100 to <300 or 300 pg/ml, compared with NT-proBNP <100 pg/ml) was associated with a graded increased risk for CVD events and mortality. Participants with SBP 130 to 139 mm Hg but NT-proBNP ≥300 pg/ml had a hazards ratio of 3.4 for CVD (95% confidence interval: 2.44 to 4.77) compared with a NT-proBNP of <100 pg/ml and SBP of 140 to 149 mm Hg.ConclusionsElevated NT-proBNP is independently associated with CVD and mortality across SBP, DBP, and PP categories and helps identify subjects at the highest risk. Participants with stage 1 hypertension but elevated NT-proBNP had greater cardiovascular risk compared with those with stage 2 SBP but lower NT-proBNP. Future studies are needed to evaluate use of biomarker-based strategies for CVD risk assessment to assist with initiation or intensification of BP treatment. 相似文献
94.
Aisa Y Mori T Nakazato T Yamazaki R Yamagami J Amagai M Ikeda Y Okamoto S 《International journal of hematology》2005,82(3):266-269
A 44-year-old woman with refractory follicular lymphoma underwent allogeneic stem cell transplantation (SCT) and achieved
complete remission. Grade III acute graft-versus-host disease (GVHD) developed on day 23, but no chronic GVHD occurred. The
patient developed severe erosion with bullous lesions in the oral cavity 18 months after SCT. At that time, the lymphoma remained
in complete remission, and she had no clinical or laboratory findings suggesting chronic GVHD. A biopsy of the oral mucosa
showed moderate lymphoplasmacytic infiltration and subepidermal bullae, and direct immunofluorescence staining demonstrated
linear deposition of C3 at the dermo-epidermal junction. An immunoblotting assay using human epidermal extracts confirmed
the presence in her serum of an antibody against the 230-kd bullous pemphigoid antigen 1 (BPAG1). A diagnosis of cicatricial
pemphigoid (CP) was made, and complete resolution of the CP was achieved with pred-nisolone therapy. The occurrence of autoimmune
blistering diseases is rare after allogeneic SCT. 相似文献
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Bokun Kim Takehiko Tsujimoto Rina So Xiaoguang Zhao Shun Suzuki Taeho Kim Kiyoji Tanaka 《Journal of Physical Therapy Science》2015,27(12):3787-3791
To prevent or remedy musculoskeletal conditions, the relationship between obesity and the
characteristics of muscle mass and strength need to be clarified. [Subjects and Methods] A
total of 259 Japanese males aged 30–64 years were classified into 4 groups according to
the Japanese obesity criteria. Body composition was evaluated, and handgrip strength and
knee extensor strength were measured for the upper and lower extremities, respectively.
Physical performance was evaluated with a jump test. [Results] Obesity was positively
correlated with skeletal muscle mass index, percentage of whole-body fat, and leg muscle
strength and negatively correlated with the percentage of muscle mass index, body
weight-normalized handgrip strength, and knee extensor strength, and the jump test
results. [Conclusion] Weight loss may be a better approach than increasing muscle mass and
strength to improve musculoskeletal conditions in obese adult males.Key words: Obesity, Muscle mass, Muscle strength 相似文献
99.
Hirata N Kushida Y Ohguri T Wakasugi S Kojima T Fujita R 《Journal of gastroenterology》1999,34(6):713-716
We present a patient with complication of huge hepatic subcapsular hematoma after extracorporeal shock wave lithotripsy (ESWL)
for pancreatic lithotripsy. The hematoma measured 78–110 mm. Angiography showed a subcapsular hematoma, rather than a hematoma
in the liver. In the arterial phase, the distal end of the small vessel showed spotty opacification similar to microaneurysma,
suggesting that it was an injury caused by separation of the liver and its capsule, caused by the shock waves. The portal
vein and hepatic vein were normal. After 8 weeks of conservative therapy, the hematoma was gradually absorbed and the patient
was discharged. Eight months after the accident, the hematoma had decreased to 40 mm in size. After 20 months, it was completely
absorbed. The reported rate of renal subcapsular hematoma after ESWL for renal or ureter stones is 0.1%–0.7%. To date, however,
only five cases of hepatic subcapsular hematoma after right renal stone disintegration have been reported. This is the first
report of hepatic subcapsular hematoma after ESWL for pancreatic stones.
Received: September 11, 1998 / Accepted: April 16, 1999 相似文献
100.
Matsushita M Uchida K Okazaki K 《Gastrointestinal endoscopy》2005,62(6):995; author reply 995-995; author reply 996