全文获取类型
收费全文 | 3459篇 |
免费 | 185篇 |
国内免费 | 26篇 |
专业分类
耳鼻咽喉 | 27篇 |
儿科学 | 65篇 |
妇产科学 | 18篇 |
基础医学 | 456篇 |
口腔科学 | 70篇 |
临床医学 | 194篇 |
内科学 | 1019篇 |
皮肤病学 | 40篇 |
神经病学 | 296篇 |
特种医学 | 150篇 |
外国民族医学 | 1篇 |
外科学 | 538篇 |
综合类 | 8篇 |
预防医学 | 48篇 |
眼科学 | 37篇 |
药学 | 206篇 |
中国医学 | 3篇 |
肿瘤学 | 494篇 |
出版年
2024年 | 3篇 |
2023年 | 32篇 |
2022年 | 62篇 |
2021年 | 115篇 |
2020年 | 67篇 |
2019年 | 72篇 |
2018年 | 95篇 |
2017年 | 79篇 |
2016年 | 96篇 |
2015年 | 119篇 |
2014年 | 120篇 |
2013年 | 171篇 |
2012年 | 256篇 |
2011年 | 228篇 |
2010年 | 145篇 |
2009年 | 128篇 |
2008年 | 190篇 |
2007年 | 207篇 |
2006年 | 209篇 |
2005年 | 209篇 |
2004年 | 216篇 |
2003年 | 210篇 |
2002年 | 235篇 |
2001年 | 44篇 |
2000年 | 20篇 |
1999年 | 34篇 |
1998年 | 47篇 |
1997年 | 31篇 |
1996年 | 40篇 |
1995年 | 30篇 |
1994年 | 40篇 |
1993年 | 21篇 |
1992年 | 12篇 |
1991年 | 11篇 |
1990年 | 11篇 |
1989年 | 5篇 |
1988年 | 9篇 |
1987年 | 11篇 |
1986年 | 5篇 |
1985年 | 3篇 |
1984年 | 3篇 |
1983年 | 6篇 |
1982年 | 4篇 |
1979年 | 5篇 |
1978年 | 3篇 |
1977年 | 2篇 |
1975年 | 2篇 |
1969年 | 1篇 |
1968年 | 1篇 |
1956年 | 1篇 |
排序方式: 共有3670条查询结果,搜索用时 15 毫秒
51.
We report herein the case of a 32-year-old woman who underwent distal gastrectomy with D2 lymph node dissection for gastric
cancer. Microscopic examination of the resected specimen revealed signet-ring cell carcinoma of the stomach with lymph node
metastases, and endosalpingiosis in the normal lymph nodes. There was no evidence of malignancy in the peritoneal cavity.
To our knowledge, no other case of endosalpingiosis in the lymph nodes along the stomach has ever been reported. The possible
significance of endosalpingiosis is discussed following this case report. 相似文献
52.
Surgical series of hearing preservation in acoustic neuroma usually emphasize a team's results with one particular technique. This report reviews acoustic neuroma outcomes of individualizing the surgical approach to patient and tumor characteristics. This study reviews 60 consecutive hearing preservation acoustic neuroma surgeries in a total series of 330 acoustic neuromas. Tumor sizes ranged from 0.3 to 4 cm in patients ranging from 23 to 74 years of age. Middle fossa surgery was performed in 57%, retrosigmoid in 43%. Overall, measurable hearing was preserved in 77%, and useful hearing in 67%. Among middle fossa cases, 85% had measurable and 74% had useful hearing. Among retrosigmoid surgeries, 65% had measurable hearing and 58% had useful hearing. Overall, long-term facial nerve function was excellent (grade I or II) in 90% and poor (grade V or VI) in 2%. There was one case of bacterial meningitis(2%), and cerebrospinal fluid leaks requiring surgery occurred in four patients (7%). The hearing preservation and other outcome parameters in this series compare favorably with other reports. We believe that individualizing the surgical approach to the patient's tumor characteristics and clinical features contributed to the high rate of hearing preservation. 相似文献
53.
Survey on visual and musculoskeletal symptoms in VDT workers] 总被引:2,自引:0,他引:2
Kazuyuki Iwakiri Ippei Mori Midori Sotoyama Kaori Horiguchi Takanori Ochiai Hiroshi Jonai Susumu Saito 《SANGYO EISEIGAKU ZASSHI》2004,46(6):201-212
With the spread of visual display terminals (VDT) in offices, the numbers of workers using VDT and the working hours at such equipment have increased rapidly in recent years. Also, preventive measures for fatigue have been proposed and the office-working environment has been improved. To examine the effects of the rapid changes in working conditions and environment on the health of VDT workers, we conducted a questionnaire survey in 2002. A self-reported questionnaire was distributed to 3,927 office workers; 2,374 (60.5%) responded. Subjects whose questionnaires had missing data were excluded from analysis. As a result, 1,406 (male: 1,069, female: 337) workers aged 20 to 59 were subjected to analysis. By a logistic regression model, we examined the association between VDT use and visual and musculoskeletal symptoms. Prevalence of eye strain and/or pain (72.1%) was the highest, followed by neck stiffness and/or pain (59.3%), low back stiffness and/or pain (30.0%) and hand or arm strain and/or pain (13.9%). Women consistently reported more discomfort than men. As a result of the logistic regression model, eye strain and/or pain was associated with dissatisfaction with airflow, but not with factors affecting visual symptoms as reported in previous studies, for example, reflection of light and blurred characters on the screen. It was thought that airflow appeared as a risk factor because the lighting environment had been improved in offices to prevent reflection of light on the screen. Neck stiffness and/or pain was associated with raising the shoulders during VDT work, the unsuitable shape of the computer mouse for a hand, and the inconvenient arrangement of the mouse in relation to the body. Hand or arm strain and/or pain were associated with the arrangement of the mouse and inappropriate height of the desk. Low back stiffness and/or pain were associated with dissatisfaction with the chair and using the keyboard without a wrist rest. Although measures to prevent fatigue had been implemented for VDT workers, risk factors for musculoskeletal symptoms would be the same as in previous studies. 相似文献
54.
Akemi Irie Akira Yamauchi Keiichi Kontani Minoru Kihara Dage Liu Yukako Shirato Masako Seki Nozomu Nishi Takanori Nakamura Hiroyasu Yokomise Mitsuomi Hirashima 《Clinical cancer research》2005,11(8):2962-2968
PURPOSE: Galectin-9, a member of the beta-galactoside-binding galectin family, induces aggregation of certain cell types. We assessed the contribution of galectin-9 to the aggregation of breast cancer cells as well as the relation between galectin-9 expression in tumor tissue and distant metastasis in patients with breast cancer. EXPERIMENTAL DESIGN: Subclones of MCF-7 breast cancer cells with high or low levels of galectin-9 expression were established and either cultured on plastic dishes or transplanted into nude mice. The tumors of 84 patients with breast cancer were tested for galectin-9 expression by immunohistochemistry. The patients were followed up for 14 years. RESULTS: MCF-7 subclones with a high level of galectin-9 expression formed tight clusters during proliferation in vitro, whereas a subclone (K10) with the lowest level of galectin-9 expression did not. However, K10 cells stably transfected with a galectin-9 expression vector aggregated in culture and in nude mice. Ectopic expression of galectin-9 also reduced MCF-7 cell adhesion to extracellular matrix proteins. Tumors of 42 of the 84 patients were galectin-9 positive, and those of 19 of the 21 patients with distant metastasis were galectin-9 negative. None of the 13 patients with galectin-9-positive tumors and lymph node metastasis up to level II manifested distant metastasis. The cumulative disease-free survival ratio for galectin-9-positive patients was more favorable than that for the galectin-9-negative group (P < 0.0001). Multivariate analysis revealed that galectin-9 status influenced distant metastasis independently of and to a greater extent than lymph node metastasis. CONCLUSIONS: Galectin-9 is a possible prognostic factor with antimetastatic potential in breast cancer. 相似文献
55.
Chihiro Shikata Masami Nemoto Takanori Ebisawa Akihiro Nishiyama Nobuakira Takeda 《Experimental & Clinical Cardiology》2011,16(3):75-76
The present article, dedicated to Dr NS Dhalla on the occasion of the jubilee of his life’s work, is a brief review of articles based on the authors’ studies of sarpogrelate conducted in collaboration with Dr NS Dhalla. These studies on the effects of sarpogrelate on cardiovascular disorders have been ongoing for more than 10 years, and 10 articles have been published to date. 相似文献
56.
Mitsuteru Yoshida Takanori Miyoshi Syoji Sakiyama Kazuya Kondo Akira Tangoku 《Surgery today》2013,43(7):806-808
A 53-year-old female with pemphigus vulgaris received treatment with prednisolone for 3 years. On chest computed tomography performed at follow-up, an anterior–mediastinal tumor (4 cm × 3 cm) was detected and diagnosed as a thymoma. Although amyosthenia was absent, the patient’s anti-acetylcholine-receptor antibody level was high, and she was positive for anti-desmoglein 3 antibodies. She underwent extended thymectomy in the same year, following which both the anti-acetylcholine receptor antibody and the anti-desmoglein 3 antibody levels were normalized. The patient’s skin symptoms improved, and the steroid dose was gradually lowered and finally discontinued 4 years postoperatively. Extended thymectomy may be an effective therapy for treating patients with pemphigus. 相似文献
57.
58.
59.
Shunsuke Uno Yosuke Horiuchi Takae Uchida Akiko Yonaha Takanori Miyata Eiko Nagano Takao Kodama Naoki Hasegawa 《Journal of infection and chemotherapy》2018,24(10):849-851
Aggregatibacter actinomycetemcomitans is well-known as the pathogen of gingivitis or periodontitis, and discitis or vertebral osteomyelitis cases caused by this organism have rarely been reported. Ampicillin or amoxicillin has been used in the previously reported discitis cases; however, no cases have been reported that is treated with levofloxacin. We report the first published case we chose levofloxacin to treat. We failed to perform the susceptibility testing because of the poor growth and fastidious nature of the organism, and the result of susceptibility of amoxicillin was unclear. Levofloxacin, which A. actinomycetemcomitans is usually susceptible to, can be an effective alternative oral antimicrobial agent in such cases. 相似文献