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91.
G Taieb C Duflos D Renard B Audoin E Kaphan J Pelletier N Limousin C Tranchant S Kremer J de Sèze R Lefaucheur D Maltête D Brassat M Clanet P Desbordes E Thouvenot L Magy T Vincent JL Faillie N de Champfleur G Castelnovo S Eimer DF Branger E Uro-Coste P Labauge 《Archives of neurology》2012,69(7):847-855
BACKGROUND Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) is a central nervous system inflammatory disease. OBJECTIVE To describe the disease course of CLIPPERS. DESIGN A nationwide study was implemented to collect clinical, magnetic resonance imaging, cerebrospinal fluid, and brain biopsy specimen characteristics of patients with CLIPPERS. SETTING Academic research. PATIENTS Twelve patients with CLIPPERS. MAIN OUTCOME MEASURES The therapeutic management of CLIPPERS was evaluated. RESULTS Among 12 patients, 42 relapses were analyzed. Relapses lasted a mean duration of 2.5 months, manifested frequent cerebellar ataxia and diplopia, and were associated with a mean Expanded Disability Status Scale (EDSS) score of 4. Besides typical findings of CLIPPERS, magnetic resonance imaging showed brainstem mass effect in 5 patients, extensive myelitis in 3 patients, and closed ring enhancement in 1 patient. Inconstant oligoclonal bands were found on cerebrospinal fluid investigation in 4 patients, with an increased T-cell ratio of CD4 to CD8. Among 7 available brain biopsy specimens, staining was positive for perivascular CD4 T lymphocytes in 5 samples. Thirty-eight of 42 relapses were treated with pulse corticosteroid therapy, which led to improvement, with a mean residual EDSS score of 1.9 (range, 0-7). In 1 patient with untreated relapses, scores on the EDSS progressively increased to a score of 10 at death. Among 5 patients without long-term corticosteroid therapy, the mean annualized relapse rate was 0.5 (range, 0.25-2.8). Among 7 patients taking oral corticosteroids, no relapses occurred in those whose daily dose was 20 mg or higher. No progressive course of CLIPPERS was observed. Four patients with a final EDSS score of 4 or higher had experienced previous severe relapses (EDSS score, ≥5) and brainstem and spinal cord atrophy. CONCLUSIONS CLIPPERS is a relapsing-remitting disorder without progressive forms. Long-term disability is correlated with the severity of previous relapses. Further studies are needed to confirm that prolonged corticosteroid therapy prevents further relapses. 相似文献
92.
Philippe Maury Pascal Defaye Didier Klug Christine Alonso Frederic Anselme Laurent Fauchier Estelle Gandjbakhch Daniel Gras Jean-Sylvain Hermida Gabriel Laurent Jacques Mansourati Eloi Marijon Frederic Sacher Jérôme Taieb Serge Boveda Olivier Piot Nicolas Sadoul 《Archives of Cardiovascular Diseases》2019,112(1):67-73
93.
Hampig Kourie Edouard Auclin Antonio Sa Cunha Sebastien Gaujoux Mathieu Bruzzi Alain Sauvanet Nelson Lourenco Isabelle Trouilloud Samy Louafi Ahmad El-Hajjar Jean Christophe Vaillant Denis Smith Yann Touchefeu Jean-Baptiste Bachet Daniel Pietrasz Julien Taieb 《Clinics and research in hepatology and gastroenterology》2019,43(6):663-668
94.
95.
M.-A. Richard J.-F. Sei C. Philippe C. Taieb P. Joly K. Ezzedine 《Annales de dermatologie et de vénéréologie》2021,148(1):28-33
BackgroundAtopic dermatitis (AD) and psoriasis (Pso) are highly prevalent chronic inflammatory skin diseases. They share similarities regarding severity and impact on quality of life but display differences regarding risk factors, comorbidities, and pathogenesis.ObjectiveThis study sought to assess the prevalence of AD and Pso among the French population, along with associated comorbidities, and to compare these data with those of the age- and gender-adjusted French population with neither AD nor Pso.MethodsThe survey was conducted by a polling institute between September 1 and November 30, 2016, with proportional quota sampling being applied to render the study population representative of the French population. In all, 20 012 individuals were selected from among 900,000 internet users aged ≥ 15 years.ResultsOverall, 20,012 adults (48.8% men; 51.2% women) completed a digital questionnaire. The prevalence of AD was 4.65% [95% confidence interval (CI) 4.36%–4.94%] and that of Pso was 4.42% [95% CI: 4.14%–4.71%]. More AD patients presented ≥ 1 comorbidity compared to subjects without AD (57.04% vs. 49.2%, P < 0.0001) and more Pso patients presented ≥ 1 comorbidity compared to subjects without Pso (60.68% vs. 49.05%, P < 0.0001). After adjustment for gender and age, hypertension and dyslipidemia, a greater prevalence of osteoarticular, respiratory and psychiatric diseases was noted in both AD and Pso patients, whereas increased prevalence of obesity was seen only in Pso patients. The prevalence of components of metabolic syndrome was higher among Pso than AD patients.ConclusionFurther studies are required to consolidate these findings, to better characterize the entire spectrum of AD and Pso comorbidities, and to better identify determinants and risk factors, along with targeted therapies. 相似文献
96.
97.
An Innovative Oat‐Based Sterile Emollient Cream in the Maintenance Therapy of Childhood Atopic Dermatitis
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Valerie Mengeaud Ph.D Chloe Phulpin Pharm.D. Adeline Bacquey C.R.A. Franck Boralevi M.D. Anne‐Marie Schmitt M.D. Alain Taieb M.D. 《Pediatric dermatology》2015,32(2):208-215
Although emollients are recommended in the management of atopic dermatitis (AD), regimens for emollient maintenance therapy are awaiting validation. We conducted an international, multicenter, open‐label trial to assess the effects of a 3‐month maintenance treatment regimen with a sterile, preservative‐free emollient cream containing oat plantlets in children (ages 6 mos–6 yrs) with moderate AD. After a 14‐day run‐in stabilization phase using a topical corticosteroid (TCS) treatment of medium potency, 108 children with a SCORing Atopic Dermatitis (SCORAD) index of 20 or less were included in the study. Emollient was applied twice daily for 3 months. Rescue TCS treatment was used only in cases of flare‐ups. The SCORAD index, Patient‐Oriented SCORAD (PO‐SCORAD) index, number of flares, TCS use, and tolerance were assessed at months 1, 2, and 3 (M1, M2, M3). AD severity improved, with a highly significant decrease in the SCORAD and PO‐SCORAD indexes at M2 and M3 (p < 0.001). Changes from baseline to M3 were 48.6 ± 73.6% for SCORAD and 29.6 ± 125.3% for PO‐SCORAD. The number of flares and TCS use significantly decreased by M3 (both p < 0.001). Very good tolerance was recorded in 100% of children at M2 and M3. Notwithstanding the limitations inherent in open‐label trials, twice daily application of the oat‐based sterile emollient cream led to a significant improvement of clinical symptoms, evidenced by parallel changes in the SCORAD and PO‐SCORAD indexes and fewer flare‐ups. Clinical benefit and less TCS use were maintained at M3. Tolerance was very good. 相似文献
98.
99.
Shimaa Abdalla Ahmed Hanan Ahmed El Taieb 《The Egyptian Journal of Radiology and Nuclear Medicine》2018,49(3):828-837
Objectives
To describe the patient characteristics, imaging features, biomarkers raising the possibility of secondary ovarian tumors. How imaging features of secondary ovarian tumors vary according to the origin of the primary tumor.Methods
Between January 2012 and September 2016, we conducted a retrospective study of 50 pathologically confirmed ovarian metastasis. We reviewed patient's medical records and retrieved their clinicopathological characteristics and reviewed their radiological images to evaluate discrepancies in the imaging features between ovarian metastasis and the primary tumor.Results
The majority of our patients were younger than 50y (72%), had bilateral ovarian metastasis (64%), elevated CA-125 (64%), lesion less than 9?cm (68%), and have mixed solid and cystic lesion (82%). 70% of lesions with solid component has a moderate pattern of enhancement. While, 90% of ovarian metastasis derived from cancer stomach, breast, lymphoma was solid; 81% of metastases arising from the primary tumor in the small intestine, colon, rectum or biliary tract was mixed (P?<?0.0001). Also, Metastases from the primary tumor in the stomach, breast, and lymphoma were significantly smaller than those from colorectal or biliary tract cancers (P?=?0.02).Conclusion
possibility of secondary ovarian tumors should be considered in cases with bilateral relatively small solid ovarian tumors in a woman with age <50?years old with normal or mild elevated CA 125 level. Imaging features may differ according to the primary tumor. 相似文献100.
Schartz NE Chaput N Taieb J Bonnaventure P Trébeden-Nègre H Terme M Ménard C Lebbé C Schimpl A Ardouin P Zitvogel L 《European journal of immunology》2005,35(10):2840-2850
Dendritic cells (DC) are unique antigen-presenting cells capable of triggering NK cell effector functions and priming naive T cells in vivo. Microbial stimulation induces early IL-2 production by mouse DC. Previous reports demonstrated that IL-2 is enriched at the site of DC/T cell interaction and promotes allogeneic T cell proliferation. However, the direct role of DC-derived IL-2 in the differentiation of cytotoxic T lymphocytes and in NK cell triggering in vivo has not been investigated. Lipopolysaccharide (LPS) stimulation of mouse bone marrow-derived DC results in early IL-2 production unless IL-4 is introduced in DC cultures. Here we show that IL-2 produced by LPS-activated DC is dispensable for cognate T cell responses since IL-2 loss of function DC elicit OVA-specific Tc1 effector and memory lymphocytes in draining lymph nodes in a setting where ex vivo cultured DC do not transfer antigens to host DC. Moreover, adoptively transferred IL-2 loss of function DC maintain their capacity to trigger NK cell proliferation/recruitment in lymph nodes. Therefore, immediate inducible IL-2 production by DC following microbial infection might play a regulatory role at ports of entry rather than in secondary lymphoid organs. 相似文献