全文获取类型
收费全文 | 10651篇 |
免费 | 479篇 |
国内免费 | 84篇 |
专业分类
耳鼻咽喉 | 234篇 |
儿科学 | 293篇 |
妇产科学 | 118篇 |
基础医学 | 1850篇 |
口腔科学 | 222篇 |
临床医学 | 614篇 |
内科学 | 2571篇 |
皮肤病学 | 218篇 |
神经病学 | 764篇 |
特种医学 | 344篇 |
外科学 | 1656篇 |
综合类 | 30篇 |
预防医学 | 215篇 |
眼科学 | 148篇 |
药学 | 673篇 |
中国医学 | 36篇 |
肿瘤学 | 1228篇 |
出版年
2023年 | 55篇 |
2022年 | 112篇 |
2021年 | 227篇 |
2020年 | 120篇 |
2019年 | 161篇 |
2018年 | 182篇 |
2017年 | 180篇 |
2016年 | 189篇 |
2015年 | 192篇 |
2014年 | 275篇 |
2013年 | 358篇 |
2012年 | 590篇 |
2011年 | 702篇 |
2010年 | 398篇 |
2009年 | 316篇 |
2008年 | 527篇 |
2007年 | 608篇 |
2006年 | 620篇 |
2005年 | 668篇 |
2004年 | 662篇 |
2003年 | 643篇 |
2002年 | 703篇 |
2001年 | 247篇 |
2000年 | 148篇 |
1999年 | 199篇 |
1998年 | 161篇 |
1997年 | 152篇 |
1996年 | 133篇 |
1995年 | 96篇 |
1994年 | 114篇 |
1993年 | 125篇 |
1992年 | 152篇 |
1991年 | 121篇 |
1990年 | 107篇 |
1989年 | 108篇 |
1988年 | 94篇 |
1987年 | 81篇 |
1986年 | 89篇 |
1985年 | 64篇 |
1984年 | 66篇 |
1983年 | 48篇 |
1982年 | 45篇 |
1981年 | 38篇 |
1980年 | 40篇 |
1979年 | 30篇 |
1978年 | 38篇 |
1977年 | 30篇 |
1976年 | 24篇 |
1973年 | 21篇 |
1967年 | 19篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
941.
942.
Kakio T Matsumori A Ohashi N Yamada T Nobuhara M Saito T Kawamoto A Taguchi A Morita Y Takahashi M Sasayama S 《Internal medicine (Tokyo, Japan)》2003,42(11):1084-1089
OBJECTIVE: Stenting of small coronary arteries has always been limited by high rates of restenosis, and restenosis has mainly been attributed to inflammatory reactions resulting in cell proliferation and intimal hyperplasia. Based on our experience for several years, we retrospectively investigated the effect of hydrocortisone on reducing in-stent restenosis. PATIENTS AND METHODS: Study population consisted of consecutive 166 patients, 221 lesions, who electively underwent stent implantations stent diameter less than 3 mm into coronary arteries between February 1999 and October 2002. We intravenously administered hydrocortisone before the procedure to 40 patients for preventing allergic reactions due to contrast material, and the effect of hydrocortisone on reducing restenosis was retrospectively compared with 126 patients who did not receive this treatment. RESULTS: There was no significant difference in the prevalence of diabetes mellitus, hyperlipidemia, or hypertension between the two groups. There was no significant difference in the type of lesion, length of stent, balloon/artery ratio, or initial success rate between the two groups, but stent diameter was significantly smaller in the hydrocortisone group compared with the control group. On six-month angiographic follow-up, the restenosis rate was significantly lower in the hydrocortisone group compared with the control group (16.2% vs 34.0%, respectively), and the target lesion revascularization rate was also significantly lower in the hydrocortisone group compared with the control group (13.2% vs 27.5%, respectively). CONCLUSION: These results suggest that intravenous administration of hydrocortisone reduces in-stent restenosis of small coronary arteries. Prospectively controlled trials will be necessary to confirm this preventive effect of hydrocortisone. 相似文献
943.
Tatsuo Yamakawa Seiji Itoh Kunihiro Hirosawa Tadashi Miyoshi Kazutomi Katoh Seishi Iizumi Keisuke Kawabata 《The American journal of gastroenterology》1983,78(10):649-651
An implant metastasis developed along the tract after percutaneous transhepatic cholecystoscopy 5 months after initial placement of the catheter into the gallbladder. Percutaneous transhepatic cholecystoscopy is conducted by insertion of choledochofiberscope into the gallbladder through the dilated sinus tract established around a catheter inserted into the gallbladder. The catheter had been placed for total of 15 days. Two days after the removal of the catheter, cholecystectomy supplemented by partial resection of the liver was carried out because of the extent of a gallbladder carcinoma. The choledochofiberscope used was Olympus CHF type 4B, with a thinner flexible part 5.0 mm in diameter. It is not surprising that carcinoma of the biliary tract or pancreas may seed along the tract of a biliary drainage catheter, but only few reports describing such incidence related to percutaneous transhepatic biliary drainage have previously been published. Physicians should be aware of this complication whenever a firm nodule develops at the site of previous entry of a biliary drainage catheter in a patient with malignant obstruction. 相似文献
944.
Yamaguchi M Yamamoto T Tate G Matsumoto T Matsumiya A Kuzume M Sanada Y Kumada K 《Journal of gastroenterology》2000,35(7):563-566
A case of inflammatory pseudotumor of the spleen is described in a 63-year-old woman who presented with an intrasplenic tumor
and an elevated serum level of soluble interleukin 2 receptor (sIL-2R). Microscopic examination after removal of the spleen
revealed that the tumor was composed of mixed cellular infiltrates, mainly lymphocytes and plasma cells, and spindle-cell
proliferation. Epstein-Barr virus (EBV) was specifically detected in the tumor by in situ hybridization for EBV RNA. The serum
level of sIL-2R level was normalized after splenectomy. EBV infection may play a role in the development of splenic inflammatory
pseudotumor and the elevation of sIL-2R level.
Received: May 27, 1999 / Accepted: November 26, 1999 相似文献
945.
Mutsumi Fujii Kazuhiko Nakagawa Hiroki Tomita Osamu Tone Masashi Tamaki Yoshiaki Takada Mitsuhiko Hokari Tadashi Nariai Kikuo Ohno 《Journal of clinical neuroscience》2010,17(9):1136-1139
Whether the intentional antihypertensive therapy recommended by the American Heart Association/American Stroke Association (AHA/ASA) guidelines has clinical benefit for patients who have acute spontaneous intracerebral hemorrhage (ICH) has yet to be proven. We retrospectively reviewed the clinical charts of 175 patients with putaminal or thalamic ICH with acute hypertension to examine the correlation between the efficacy of antihypertensive therapy within 3 hours of onset, hematoma expansion (HE) after hospitalization and clinical outcome. The aim of the antihypertensive therapy was to achieve and maintain a systolic blood pressure of 120 mm Hg to 160 mm Hg until the second CT scan. The mean arterial pressure (MAP) after admission was the average MAP values measured every hour for the first 3 hours of hospitalization or until the second CT scan, if this was performed within the same timeframe. Thirty-two (18.3%) patients were found to have HE. Prior to the second CT scan, antihypertensive medications were administered to all patients without any major complications. A multiple logistic regression analysis revealed that a MAP of >110 mm Hg after admission was the only variable independently associated with HE (odds ratio [OR] = 3.455; 95% confidence interval [CI] = 1.510–8.412; p = 0.004). Modified Rankin Scale scores of ?3 on day 30 were significantly more common in those patients without HE (p = 0.002).Our findings suggest that there are clinical benefits, by the prevention of subsequent HE, in maintaining a MAP level lower than that recommended by the AHA/ASA (110 mm Hg) after hospitalization for patients who have ICH. 相似文献
946.
Kota Agematsu M.D. Yuji Naito M.D. Mitsuru Aoki M.D. Tadashi Fujiwara M.D. 《Journal of cardiac surgery》2010,25(4):417-418
Abstract A two and a half year old girl who had undergone the Yasui procedure as a neonate for ventricular septal defect, subaortic stenosis, and interrupted aortic arch underwent follow‐up catheterization 2 years postoperatively. It showed that the neo‐left ventricular tract reconstructed by Damus‐Kaye‐Stansel anastomosis had occluded due to closure of the ventricular septal defect and residual subaortic stenosis at the original left ventricular outflow tract. The patient therefore underwent takedown of the Yasui procedure . (J Card Surg 2010;25:417‐418) 相似文献
947.
948.
Hitoshi Yoshiji Ryuichi Noguchi Kosuke Kaji Yasuhide Ikenaka Yusaku Shirai Tadashi Namisaki Mitsuteru Kitade Tatsuhiro Tsujimoto Hideto Kawaratani Hiroshi Fukui 《Journal of gastroenterology》2010,45(4):443-450
Background
Insulin resistance (IR) is reportedly involved in the progression of hepatocellular carcinoma (HCC). Because neovascularization plays an important role in HCC, including hepatocarcinogenesis, an angiostatic therapy would be a promising approach for chemoprevention against HCC. The aim of the present study was to examine the combined effect of clinically used branched-chain amino acids (BCAAs) and an angiotensin-converting enzyme inhibitor (ACE-I), in conjunction with neovascularization, on hepatocarcinogenesis under the condition of IR. 相似文献949.
Tadashi Nakamura Syu-ichi Higashi Kunihiko Tomoda Michishi Tsukano Masahiro Shono 《Clinical rheumatology》2010,29(12):1395-1401
The benefit of biological therapies in rheumatoid arthritis (RA) treatment is well known, but their role in amyloid A (AA)
amyloidosis secondary to RA is unclear. The aim of this study was to clarify the clinical benefit of etanercept in RA patients
with AA amyloidosis. We treated 14 RA patients who had serum amyloid A protein (SAA) 1.3 allele, with biopsy-confirmed AA
amyloidosis with etanercept and investigated the efficacy of etanercept treatment, focusing on renal function retrospectively.
The AA amyloidosis improved and stabilized after 89.1 ± 27.2 weeks. Proteinuria decreased from 2.24 ± 0.81 to 0.57 ± 0.41 g/day
(P < 0.01) and SAA fell from 250 ± 129 to 26 ± 15μg/ml (P < 0.01), respectively. Diarrhea secondary to gastrointestinal AA amyloidosis was less. Overall, the serum creatinine levels
did not benefit with treatment, but in those with a creatinine values <2.0 mg/dl the creatinine level continued to fall (P = 0.021). Serum albumin increased following 96 weeks of etanercept treatment (P = 0.003). Etanercept treatment led to clinical improvement in proteinuria and serum albumin levels accompanied by a fall
in SAA levels. 相似文献
950.
Tadashi Wada Mitsuru Abe Nobuhito Yagi Nobuaki Kokubu Yoichiro Kasahara Yu Kataoka Yoritaka Otsuka Yoichi Goto Hiroshi Nonogi 《Heart and vessels》2010,25(3):263-266
Coronary vasospasm can be induced by allergic reactions with some chemical mediators, and the angina and myocardial infarction
secondary to allergy-induced coronary vasospasm are referred to as “Kounis syndrome.” Only two cases of Kounis syndrome following
food ingestion have been reported. However, they had pre-existing atheromatous coronary artery disease, and no provocation
test to induce coronary vasospasm was done. We describe here another probable case of allergic vasospasm after food intake.
To the best of our knowledge, this is the first documented report of a patient with food-induced allergic vasospasm subsequent
to the provocation test with ergometrine maleate. 相似文献