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991.
Blood flow velocities in the vertebrobasilar system during migraine attacks a transcranial Doppler study 总被引:3,自引:0,他引:3
CP Zwetsloot JFV Caekebeke JC Jansen J Odink MD Ferrari 《Cephalalgia : an international journal of headache》1992,12(1):29-32
In this study, blood flow velocity in the basilar artery and both vertebral and middle cerebral arteries was measured with a transcranial Doppler device in 23 migraineurs during and outside a migraine attack. The aim of the study was to compare blood flow velocities during and outside an attack and to examine vascular reactivity to voluntary hyperventilation during both conditions. No differences in blood flow velocity were found. Although blood pressure was increased and end-expiratory CO2 decreased during the attack, this exerted no influence on blood flow velocity. Neither was a difference in vascular reactivity to voluntary hyperventilation detected between the two conditions. These findings support the notion of functional integrity of the examined large arteries during migraine attacks without aura. 相似文献
992.
Meredith L Borland MBBS Stuart R Dalziel PhD Natalie Phillips MBBS Sarah Dalton BMed Mark D Lyttle MBChB Silvia Bressan PhD Ed Oakley MBBS Amit Kochar MD Jeremy Furyk PhD John A Cheek MBBS Jocelyn Neutze MBChB Nitaa Eapen BSc Stephen JC Hearps MBiostat Vanessa C Rausa MPsych Franz E Babl MD the Paediatric Research in Emergency Departments International Collaborative group 《Emergency medicine Australasia : EMA》2023,35(2):289-296
993.
JC Tantchou Tchoumi Sara Foresti Pierpaolo Lupo Cappato Riccardo Gianfranco Butera 《Cardiovascular journal of Africa》2012,23(10):538-540
Aim
The purpose of the study was to assess the incidence and survival rate of patients with complete atrio-ventricular block in the cardiac centre of St Elizabeth Catholic General Hospital, Kumbo, Cameroon.Methods
Between 2009 and 2011, 26 patients with complete atrio-ventricular block were diagnosed at our institution. Complete atrio-ventricular block was defined as complete heart block, diagnosed by echocardiographic or electrocardiographic documentation of the dissociation between electrical activity of the atria and ventricles. Hospital charts, electrocardiograms (ECG), echocardiography and chest radiography were reviewed.Results
The triad of symptoms that pointed to the diagnosis of complete atrio-ventricular block was mainly fatigue, shortness of breath on mild physical exertion, and dizziness. The median age at diagnosis was 65 ± 15 years. The escape rhythm showed a narrow QRS complex in 35.2% of patients, whereas wide QRS complexes were seen in 64.8%. In only 15 patients were pacemakers implanted: dual-chamber in 10 and single-chamber in five cases, depending on the availability of the pacemakers. During the observational period, five non-implanted patients died, giving a mortality rate of 45%. We recorded no deaths in patients with pacemakers.Conclusion
In developing countries, natural selection is observed in patients with complete atrio-ventricular block. Lack of infrastructure and early detection, and financial limitations are the main problems faced in the follow up of these patients. Re-organisation of the public health system, new programmes for the prevention of cardiovascular diseases, and government subsidisation are needed in our milieu. 相似文献994.
Evaluation of quality of life in patients with toenail onychomycosis by Polish version of an international onychomycosis-specific questionnaire 总被引:1,自引:0,他引:1
JC Szepietowski† A Reich† P Pacan‡ E Garlowska§ E Baran† 《Journal of the European Academy of Dermatology and Venereology》2007,21(4):491-496
BACKGROUND: Onychomycosis is the most frequent nail disease, which could impair the patient's quality of life. OBJECTIVE: The present study was undertaken to evaluate the impact of toenail onychomycosis on quality of life among Polish population. PATIENTS AND METHODS: Three thousand nine-hundred and four (3904: 2269 females and 1635 males) individuals fulfilled an international onychomycosis-specific quality-of-life questionnaire consisting of statements regarding social, emotional and symptoms problems. All patients had toenail onychomycosis confirmed by the positive direct microscopic examination and/or by the positive mycologic culture. Seven hundred and sixty-seven patients simultaneously had fingernail onychomycosis. All patients were divided into subgroups according to sex, age, education level, place of living, type of onychomycosis, number of involved toenails, fingernails involvement, duration of illness and previously used antimycotic therapy. RESULTS: Most of the patients demonstrated significantly reduced quality of life. The degree of life impairment varied between analysed subgroups. Patients with more advanced toenail onychomycosis and with fingernail involvement were more seriously affected. Both social and emotional impairments were more pronounced in female than in male patients, although there were no differences according to symptoms. Moreover, patients with better educational level and people living in towns or cities were more emotionally and socially affected by onychomycosis, although people living in the country or with poorer education level presented with significantly more severe symptoms. CONCLUSIONS: Toenail onychomycosis is still a serious medical problem, which can significantly reduce the patient's quality of life. 相似文献
995.
Liang Chen Lu-Zheng Liu Jia-Cheng Chen Da-Feng Xu Cheng Chen Shi-Xun Lin Xiang-Xiang Luo Jin-Cai Wu 《Hepatobiliary & pancreatic diseases international : HBPD INT》2023,22(3):326-330
<正>To the Editor: Liver tumor may occur in any hepatic segment or lobe, and thus the liver resection is individualized as per the location and size of the tumor. In addition, the resection of the posterior and caudate lobes of the liver is especially difficult amongst all types of hepatectomy. Kawaguchi et al. believed that the laparoscopic resection of right posterior liver lobe was a difficult surgical procedure [1]. 相似文献
996.
997.
Toxaphene (polychlorinated camphenes) is an insecticidal mixture of >670
chemicals, which was widely used until the mid 1980s. Due to their
lipophilic and volatile nature, these chemicals accumulate in animal and
human tissues and continue to be a major contaminant in marine and
freshwater biota. Cytotoxic and genotoxic effects in mammalian test systems
suggest that toxaphene is a carcinogen and reports support the hypothesis
that toxaphene could have tumor-promoting potential in human breast tissue.
In order to examine the potential of toxaphene as an environmental
endocrine disrupter, we investigated its effect on the estrogen receptor
(ER) function in human breast cancer MCF-7 cells. Using transient gene
expression experiments, we observed approximately 60% and 80% inhibition of
the constitutive and 17beta-estradiol induced ER-dependent transactivation,
respectively. The involvement of the ER in the ability of toxaphene to
block the estrogen action was verified by cotransfection studies in
ER-negative MDA-MB-231 cells. The interference of toxaphene with the ER
mediated responses was supported by a significant suppression of
endogenously expressed pS2 RNA and decreased levels of secreted pS2
protein. These reproducible results indicate that toxaphene can disturb
hormonal signals mediated by the ER and suggest that these environmental
chemicals have potential endocrine disrupting activities which may affect
the reproductive health and increase the risk of carcinogenesis.
相似文献
998.
999.
1000.
Delchier JC Elamine I Goldfain D Chaussade S Barthelemy P Idstrom JP 《Alimentary pharmacology & therapeutics》1996,10(3):263-268
AIM: To assess the effect of adding clarithromycin to the combination of omeprazole and amoxycillin for the eradication of H. pylori infection. PATIENTS AND METHODS: In an open, randomized, three-centre study 120 patients (69 men, mean age 47 years, caucasians 74%) with symptoms of dyspepsia had normal gastroscopic examination and a positive urease test. They underwent a 13C-urea breath test and received, for 14 days, either omeprazole 40 mg b.d. plus amoxycillin 750 mg b.d., or the same regimen plus clarithromycin 250 mg b.d. Compliance was assessed by returned tablet counts. H. pylori clearance at the end of treatment and eradication 4 weeks after finishing treatment were assessed by 13C-urea breath test. RESULTS: Results are expressed according to 'all patients treated analysis', excluding patients who did not receive treatment and patients who had no final 13C-urea breath test assessment. In the groups treated with omeprazole- amoxycillin or omeprazole-amoxycillin-clarithromycin good compliance (> or = 90%) was observed in 85% vs. 76% (N.S.) of patients but 25% vs. 34% (N.S.) experienced at least one adverse event. Adverse events were minor, and no patient reported a metallic taste. Four weeks after finishing treatment eradication rates were 26% (95% CI: 15-37%) vs. 93% (95% CI: 86-99%) (P < 0.001). CONCLUSION: These results show that dual therapy with omeprazole plus amoxycillin achieves an unacceptably low H. pylori eradication rate. Addition of clarithromycin at low dosage (250 mg b.d.) proved to be useful, achieving a high eradication rate without increasing side-effects. 相似文献