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11.
TOSHIHIRO OHYA SUSUMU OHWADA YOSHIYUKI KAWASHIMA YOSHIFUMI TANAHASHI TORU TAKAHASHI HIDEAKI ICHIKAWA NAOKI TOMIZAWA YASUO MORISHITA 《Journal of gastroenterology and hepatology》1998,13(8):781-785
This study was designed to elucidate the efficacy of University of Wisconsin (UW) solution for preventing liver injury, when used as a hypothermic perfusate infused into the systemic circulation during extended hepatectomy with hepatic inflow occlusion. Adult mongrel dogs (9.5–17.5 kg, n= 14) were subjected to 75% hepatectomy under 60 min hepatic inflow occlusion. The animals were divided into two groups. The UW group (n= 7) underwent hypothermic perfusion using 4°C UW solution (core temperature of the liver: 12.3±0.2°C). The control group designated as the Ringer's lactate (LR) group (n= 7) underwent hypothermic perfusion using 4°C LR solution. The perfusate was introduced into the systemic circulation via the hepatic vein. Blood from the hepatic vein was sampled, and alanine amino-transferase, purine nucleoside phosphorylase activities and the ammonia concentration were measured. The 7 day survival rate was higher in the UW group than in the LR group. The parameters of liver function were less significantly altered in the UW group than in the LR group. The plasma ammonia concentration was significantly (P<0.05) lower 6h after reperfusion in the UW group than in the LR group. A small volume of hypothermic perfusion of the liver using UW solution was safe if it returned to systemic circulation. Hypothermic perfusion of the liver using UW solution may be effective for preventing hepatic tissue injury during extended hepatectomy with hepatic vascular occlusion. 相似文献
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TAKAHIRO SATO KATSU YAMAZAKI JOUJI TOYOTA YOSHIYASU KARINO TAKUMI OHMURA YASUAKI KUWATA JUN AKAIKE TOSHIHIRO SUGA 《Digestive endoscopy》2003,15(2):87-92
Background: Endoscopic color Doppler ultrasonography (ECDUS) is a useful modality for obtaining color flow images of esophageal varices. Levovist is a microbubble echo‐enhancing agent that improves Doppler ultrasound examination. This study is designed to evaluate the usefulness of ECDUS using Levovist in diagnosing palisade veins of esophageal varices. Methods: The study involved 67 patients with esophageal varices using ECDUS. All 67 patients received Levovist intravenously at a concentration of 300 mg/mL. A 7.5‐mL dose of the contrast agent was injected at a slow infusion rate of 1 mL/min. We compared vessel images detected with precontrast with those detected by enhanced ECDUS. Results: Color flow images of palisade veins were obtained in 16 (23.9%) of the 67 patients with precontrast ECDUS. Vessel images of palisade veins were detected in 15 of 61 F2 type varices (24.6%) and in one of six F3 varices (16.7%). The color flows of these vessels showed a continuous wave on fast‐Fourier transform analysis. Sixteen palisade veins had velocities in the 3.3 cm/s?11.6 cm/s range. Color flow images of palisade veins were obtained in 27 (40.3%) of the 67 cases by enhanced ECDUS using Levovist. Palisade veins could be delineated after Levovist contrast in 11 patients who could not be detected on precontrast ECDUS. After Levovist contrast, color flow images detected with precontrast ECDUS were enhanced in all patients. Conclusion: Endoscopic color Doppler ultrasonography with Levovist contrast can improve the diagnostic quality of the palisade veins in esophageal varices. 相似文献
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MOTOTSUGU KATO YUICHI SHIMIZU SOUICHI NAKAGAWA TOSHIRO SUGIYAMA MASAHIRO ASAKA 《Digestive endoscopy》2003,15(Z1):S2-S7
Isolated exfoliation method of gastric endoscopic mucosal resection (EMR) as a new technique has not yet reached the popularity of the conventional EMR techniques. From the results of a questionnaire about EMR in the stomach, the isolated exfoliation method has the advantage of permitting en bloc and histologically complete resection regardless of lesion size. However, this method has the disadvantage of long performance time and high frequency of complication as well as the need for a high level of technical skill. New devices and ideas are needed for the development of the isolated exfoliation method. 相似文献
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Background: Serotonin–dopamine antagonists (SDAs) inhibit dopaminergic transmission in the mesolimbic system less than in the nigrostriatal dopaminergic pathway, which relates to the extrapyramidal side‐effects of these drugs. The SDAs seem to have an adequate receptor binding profile for the management of the behavioral and psychiatric symptoms of dementia. However, clinicians are discouraged from prescribing SDAs for elderly patients because of an advisory statement from the US Food and Drug Administration that warns about an increased mortality rate among elderly patients treated with atypical antipsychotics. Methods: We conducted a retrospective study involving 16 elderly patients (mean age 84.9 years; range 67–94 years) with delirium who were treated with one of two SDAs, namely perospirone (4–12 mg/day) or risperidone (1–2 mg/day). The time‐course of their psychiatric symptoms was assessed using subcategories of the Delirium Rating Scale (DRS) before treatment and on Days 10 and 24 of treatment. Results: Total DRS scores were significantly decreased from baseline in both treatment groups. Both agents led to significant improvements from baseline in psychomotor behavior and lability of mood. Of interest, perospirone decreased hallucinations and delusions and improved sleep–awake cycle disturbances compared with baseline. No serious side‐effects were seen with either drug. Conclusions: Both perospirone and risperidone are effective in the management of delirium in elderly patients. The improvement in the sleep–awake cycle with perospirone may be derived from its short pharmacological half‐life. 相似文献
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Summary Mechanical cleaning of dentures is effective in preventing infections such as aspiration pneumonia and denture stomatitis. For denture wearers with a physical handicap and the elderly, however, mechanical cleaning can present problems. The aim of this study was to investigate the effect of coating denture base acrylic resin with titanium dioxide (TiO2) in the inhibition of oral microbial adhesion. We prepared uniformly sized acrylic resin plates (10 mm × 10 mm × 0·5 mm), which were divided into two groups (a non‐coated group and a TiO2‐coated group). The plates were immersed in cultured Streptococcus sanguinis or Candida albicans and incubated for 24 h. After incubation, each plate was washed to remove loosely adherent microorganisms, and then incubated for a further 24 h. Adenosine triphosphate (ATP) content of the microorganisms was evaluated using a reagent containing benzalkonium, which extracts intra‐cellular ATP. In addition, to determine biofilm formation, we also observed each plate by scanning electron microscopy (SEM). We found that the ATP content of both S. sanguinis and C. albicans was reduced by the TiO2 coating (P = 0·000). Observation by SEM confirmed that the TiO2 coating inhibited biofilm formation. The results indicate that a TiO2 coating on a denture base acrylic resin inhibits adhesion of S. sanguinis and C. albicans. 相似文献
17.
Atsunobu MISUMI Ichiro YOSHINAKA Kazunori HARADA Akitoshi MURAKAMI Hirofumi KAKO Ubehiko HONMYO Shigeki OHSHIMA Makio SUGIYAMA Hironobu SUKO Shuji SUKO 《Digestive endoscopy》1989,1(1):26-35
Abstract: The findings and results obtained by endoscopies and direct vision biopsies carried out in 13 patients with early primary gastric lymphoma, were compared with those of 8 patients with RLH, 28 with depressed type of early gastric carcinoma, and 10 patients with benign gastric ulcers, to deal with problems inherent to endoscopic diagnosis of early primary gastric lymphoma The first endoscopy attained a correct diagnosis in only 1 patient (7.7%) but in 7 patients (53.8%) with the final endoscopy. Endoscopic features of early gastric lymphoma characteristically yielded a cobblestone appearance and reticulated erosion when they were compared with that of RLH, early carcinoma and benign ulcer. Furthermore, early gastric lymphoma presented ill demarcated margins associated with discoloration of the mucosa more frequently comparing with that of early gastric carcinoma. Also, hemorrhage, lustrous nodules, regulalr and white-coated ulcer were the findings more frequently seen in early gastric lymphoma but redness was less frequent in early gastric carcinoma. Dye endoscopies provided a more detailed appearance of the lesion and margins than conventional endoscopies. In addition, dye endoscopies made visible the lesions that were not visible by conventional endoscopies, in areas repelling dye solution. In this paper, the importance to pay an attention to the endoscopic findings described above and an application of dye endoscopy was emphasized for detection of an early gastric lymphoma. 相似文献
18.
Evidence for the in Vivo Localization of Heterologous Anti-Leukocyte and Anti-Bone Marrow Antibodies in the Rat Bone Marrow 总被引:1,自引:0,他引:1
1. The intravenous injection of I131-labeled heterologous anti-leukocyte and anti-bone marrow antibodies into rats resulted in a high specific in vivolocalization in the bone marrow, indicating the presence of localizing anti-body.2. No in vivo localization in lungs was demonstrated, in possible contrastto the earlier concept of pulmonary emboli of clumped leukocytes sensitizedwith antibodies in experimental immunoleukopenia.3. Heterologous anti-leukocyte and anti-bone marrow antibodies injectedintravenously disappeared from plasma and fixed to peripheral leukocytesand bone marrow cells within 1 hour. Submitted on June 25, 1962 Accepted on December 24, 1962 相似文献
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