全文获取类型
| 收费全文 | 934647篇 |
| 免费 | 67781篇 |
| 国内免费 | 1374篇 |
专业分类
| 耳鼻咽喉 | 13162篇 |
| 儿科学 | 24410篇 |
| 妇产科学 | 23278篇 |
| 基础医学 | 133511篇 |
| 口腔科学 | 28320篇 |
| 临床医学 | 80754篇 |
| 内科学 | 184220篇 |
| 皮肤病学 | 19282篇 |
| 神经病学 | 72572篇 |
| 特种医学 | 36916篇 |
| 外国民族医学 | 79篇 |
| 外科学 | 152631篇 |
| 综合类 | 18080篇 |
| 现状与发展 | 1篇 |
| 一般理论 | 234篇 |
| 预防医学 | 61883篇 |
| 眼科学 | 21354篇 |
| 药学 | 72905篇 |
| 3篇 | |
| 中国医学 | 2176篇 |
| 肿瘤学 | 58031篇 |
出版年
| 2018年 | 9042篇 |
| 2017年 | 7099篇 |
| 2016年 | 7844篇 |
| 2015年 | 8930篇 |
| 2014年 | 12107篇 |
| 2013年 | 17638篇 |
| 2012年 | 24287篇 |
| 2011年 | 25306篇 |
| 2010年 | 14934篇 |
| 2009年 | 14386篇 |
| 2008年 | 24796篇 |
| 2007年 | 25910篇 |
| 2006年 | 26675篇 |
| 2005年 | 25674篇 |
| 2004年 | 24815篇 |
| 2003年 | 23819篇 |
| 2002年 | 23341篇 |
| 2001年 | 54813篇 |
| 2000年 | 56625篇 |
| 1999年 | 47034篇 |
| 1998年 | 10778篇 |
| 1997年 | 9521篇 |
| 1996年 | 9647篇 |
| 1995年 | 8962篇 |
| 1994年 | 8319篇 |
| 1993年 | 7620篇 |
| 1992年 | 35551篇 |
| 1991年 | 33977篇 |
| 1990年 | 32790篇 |
| 1989年 | 31922篇 |
| 1988年 | 29038篇 |
| 1987年 | 28288篇 |
| 1986年 | 26333篇 |
| 1985年 | 25175篇 |
| 1984年 | 17862篇 |
| 1983年 | 15163篇 |
| 1982年 | 7813篇 |
| 1981年 | 6788篇 |
| 1979年 | 15799篇 |
| 1978年 | 10613篇 |
| 1977年 | 9063篇 |
| 1976年 | 7875篇 |
| 1975年 | 8638篇 |
| 1974年 | 10481篇 |
| 1973年 | 9868篇 |
| 1972年 | 9364篇 |
| 1971年 | 8863篇 |
| 1970年 | 8433篇 |
| 1969年 | 7930篇 |
| 1968年 | 7202篇 |
排序方式： 共有10000条查询结果，搜索用时 15 毫秒
61.
62.
Kensuke Kudou Hiroshi Saeki Yuichiro Nakashima Shun Sasaki Tomoko Jogo Kosuke Hirose Qingjiang Hu Yasuo Tsuda Koichi Kimura Ryota Nakanishi Nobuhide Kubo Koji Ando Eiji Oki Tetsuo Ikeda Yoshihiko Maehara 《American journal of surgery》2019,217(4):757-763
Background
There were few studies assessed the postoperative sarcopenia in patients with cancers. The objective of present study was to assess whether postoperative development of sarcopenia could predict a poor prognosis in patients with adenocarcinoma of esophagogastric junction, (AEG) and upper gastric cancer (UGC).Methods
Patients with AEG and UGC who were judged as non-sarcopenic before surgery were reassessed the presence of postoperative development of sarcopenia 6 months after surgery. Patients were divided into the development group or non-development group, and clinicopathological factors and prognosis between these two groups were analyzed.Results
The 5-year overall survival rates were significantly poorer in the development group than non-development group (68.0% vs. 92.6%, P?=?0.0118). Multivariate analyses showed that postoperative development of sarcopenia was an independent prognostic factor for poor overall survival (P?=?0.0237).Conclusions
Postoperative development of sarcopenia was associated with a poor prognosis in patients with AEG and UGC. 相似文献63.
Die Anaesthesiologie - Die Versorgungsforschung (VF) ist ein fachübergreifendes multidisziplinäres Forschungsgebiet, das die Kranken- und Gesundheitsversorgung sowie ihre... 相似文献
64.
65.
Dominique Trudel Luminita-Mihaela Avarvarei Michèle Orain Stéphane Turcotte Marie Plante Jean Grégoire Reinhild Kappelhoff David P. Labbé Dimcho Bachvarov Bernard Têtu Christopher M. Overall Isabelle Bairati 《Pathology, research and practice》2019,215(6):152369
Ovarian carcinoma is one of the most lethal malignancies, but only very few prognostic biomarkers are known. The degradome, comprising proteases, protease non-proteolytic homologues and inhibitors, have been involved in the prognosis of many cancer types, including ovarian carcinoma. The prognostic significance of the whole degradome family has not been specifically studied in high-grade serous ovarian cancer. A targeted DNA microarray known as the CLIP-CHIP microarray was used to identify potential prognostic factors in ten high-grade serous ovarian cancer women who had early recurrence (<1.6 years) or late/no recurrence after first line surgery and chemotherapy. In women with early recurrence, we identified seven upregulated genes (TMPRSS4, MASP1/3, SPC18, PSMB1, IGFBP2, CFI – encoding Complement Factor I – and MMP9) and one down-regulated gene (ADAM-10). Using immunohistochemistry, we evaluated the prognostic effect of these 8 candidate genes in an independent cohort of 112 high-grade serous ovarian cancer women. Outcomes were progression, defined according to CA-125 criteria, and death. Multivariate Cox proportional hazard regression models were done to estimate the associations between each protein and each outcome. High ADAM-10 expression (intensity of 2–3) was associated with a lower risk of progression (adjusted hazard ratio (HR): 0.51; 95% confidence interval (CI): 0.29-0.87). High complement factor I expression (intensity 2–3) was associated with a higher risk of progression (adjusted HR: 2.30, 95% CI: 1.17–4.53) and death (adjusted HR: 3.42; 95% CI: 1.72–6.79). Overall, we identified the prognostic value of two proteases, ADAM-10 and complement factor I, for high-grade serous ovarian cancer which could have clinical significance. 相似文献
66.
67.
Accuracy and Precision of Acetabular Component Placement With Imageless Navigation in Obese Patients
Leonard T. Buller Alexander S. McLawhorn Jose A. Romero Peter K. Sculco David J. Mayman 《The Journal of arthroplasty》2019,34(4):693-699
Background
Obesity is a risk factor for acetabular component malposition when total hip arthroplasty is performed with manual techniques. The utility of imageless navigation in obese patients remains unknown. This study compared the accuracy and precision of imageless navigation for component orientation between obese and nonobese patients.Methods
A total of 459 total hip arthroplasties performed for osteoarthritis using imageless navigation were reviewed from a single surgeon’s institutional review board–approved database. Einzel-Bild-Roentgen Analyse determined component orientation on 6-week postoperative anteroposterior radiographs. Mean orientation error (accuracy) and precision were compared between obese (body mass index ≥ 30 kg/m2) and nonobese patients. Regression analysis evaluated the influence of obesity on component position.Results
The difference in mean inclination and anteversion between obese and nonobese groups was 1.1° (43.0° ± 3.5°; range, 35.8°-57.8° vs 41.9° ± 4.4°; range, 33.0°-57.1° and 24.9° ± 6.3°; range, 14.2°-44.3° vs 23.8° ± 6.6°; range, 7.0°-38.6°, respectively). Inclination precision was better for nonobese patients. No difference in inclination accuracy or anteversion accuracy or precision was detected between groups. And 83% of components were placed within the target range. There was no relationship between obesity (dichotomized) and component placement outside the target ranges for inclination, anteversion, or both. As a continuous variable, increased body mass index correlated with higher odds of inclination outside the target zone (odds ratio, 1.06; P = .001).Conclusion
Using imageless navigation, inclination orientation was less precise for obese patients, but the observed difference is likely not clinically relevant. Accurate superficial registration of landmarks in obese patients is achievable, and the use of imageless navigation similarly improves acetabular component positioning in obese and nonobese patients.Level of Evidence
Therapeutic Level IV. 相似文献68.
Die Anaesthesiologie - Eine junge Patientin erleidet während der Anlage einer axillären Plexusblockade einen generalisierten Krampfanfall. Die Mechanismen, im Wesentlichen die vermutlich... 相似文献
69.
70.