Hypoglycemic Activity of the Total Ecdysteroid Extract from Ajuga turkestanica

Pharmaceutical Chemistry Journal -     

An interferon-like substance derived from bird fibroblasts in the treatment of human recurrent herpes simplex

In a clinical study lasting 15 months 42 patients suffering from herpes simplex were locally treated with an interferonlike substance prepared on avian fibroblast cultures. In 90% of all cases a certain improvement was achieved. In 60% reduced intensity and in 57% a shortening of prodromal symptoms was established, reduced dimensions of skin lesions were noted in 75%. In 21 patients only abortive forms without vesicles appeared. The mean duration of the herpetic episodes was reduced from 10.1 days to 4.5 days. Finally the possible mechanism of this favourable effect are discussed.     

Isolation,Chemical Analysis,and Study of the Hypolipidemic Activity of the Total Flavonoid Extract from Thermopsis altherniaflora

Pharmaceutical Chemistry Journal -     

Action of ratibol on the blood coagulation system

Oral ratibol (10 mg/kg) produced in rabbits a decrease of blood coagulability (increased the time of thromboelastogram reaction, reduced the activity of prothrombin complex according to Quick, tolerance to heparin and activity of factors II, VII, XIII and concentration of factor I). The drug administration (1 mg/kg) for 20 days caused at the first stage a decrease and at the second stage an increase of blood coagulability. At a single and 20-day administration ratibol enhanced the fibrinolytic activity, reduced the resistance of fibrin clot to streptokinase and increased the antithrombin activity.     

Experimental evaluation of the effect of a new medicinal form of tefestrol on reproduction in rats

Intramuscular injection of an oil solution of tefestrol, as well as the oral administration of tefestrol tablets and the parenteral administration of sinestron in doses of 0.01, 0.1, 1, and 5 mg/kg led to a pronounced estrogen effect in both nonpubertate and pubertate (intact and ovariectomized) rats. In the minimum dose, the estrogen activity of the injection preparation exceeded that of tablets. Preliminary tefestrol injections accelerated the fertilization and pregnancy. The injection form has a shorter latent period and produces a longer estrogen effect, while not violating fetus implantation, producing no toxic action, and having no negative influence on the pregnancy terms and the development of fetus.     

The effect of nerobol and ecdysterone on insulin-dependent processes linked normally and in insulin resistance

The effect of substances with anabolic activity (metandienone and ecdysterone phytoecdysteroid) on the manifestation of insulin effects was studied on a model of insulin resistance in rats induced by injections of hydrocortisone or by insulin insufficiency caused by alloxan. The sensitivity of the body to i. v. infusion of insulin and the reactivity of isolated fatty tissue to the hormone were increased after administration of these substances to test animals. The above effects of steroids were determined by nonspecific synthesis of total proteins in cells rather than by an increase in insulin secretion.     

The effect of proanthocyanidins from Alhagi pseudoalhagi (M. B.) Desv on the course of experimental myocardial infarct]

Intravenous proantocyanidin isolated from Alhagi pseudoalhagi (M. B.) Desv, 5-10 mg/kg, has no effects on the general hemodynamics and cardiac contractility of intact rats and rabbits. The agent given to animals with experimental myocardial infarction reduces serum creatinine phosphate levels and lipid peroxidation both in the myocardium and serum, as estimated by the amount of malonic dialdehyde and dienic conjugates), normalizes free fat acid content and cardiac phospholipid spectrum. At the same time the size of a myocardial necrotic zone became diminished.