The Moderating Effects of Rumination Facets on the Relationship Between Mindfulness and Distress Reduction

Mindfulness-based interventions have many applications, including as a productive alternative to repetitive thoughts. Rumination includes two factors: brooding (moody, maladaptive thinking) and reflection (adaptive attempt to overcome problems). Literature suggests mindfulness interventions reduce ruminative thoughts, but technique effectiveness requires examination. Our study assessed whether mindfulness techniques differ with respect to distress reduction in the context of brooding versus reflective styles. Students (N?=?228) completed questionnaires, negative mood manipulation, and a one-session mindfulness training that required either focused attention or open monitoring. Induced distress was reduced in both conditions, but brooding moderated the relationship between condition and distress reduction. Reflection was not a moderator. The findings support the idea that even a modest dose of mindfulness exercise aids in reducing induced negative emotions. Focused mindfulness may be more beneficial for reducing distress in individuals who report high levels of brooding, whereas either technique may reduce distress in individuals who reflect.     

Green emission of indium oxide via hydrogen treatment

In this work, we prepared hydrogen treated indium oxide (H₂-In₂O₃) and investigated the effect of hydrogen treatment on the optical and photoluminescence properties of In₂O₃. Hydrogen treatment has no influence on the crystal structure, but alters the intrinsic electronic structure and optical properties via introducing hydrogen induced defects such as shallow donor states (near the conduction band) and singly ionized oxygen vacancies in H₂-In₂O₃. Both air-In₂O₃ (air calcinated) and H₂-In₂O₃ show intense blue emission under UV excitation (280 nm). However, hydrogen treated In₂O₃ exhibited an additional green emission, which is absent in air-In₂O₃. This green emission arises from the passivation of singly ionized oxygen vacancies by hydrogen treatment. Hydrogen treatment could be a promising strategy to tune the electronic and optical properties of In₂O₃.

H₂-treated In₂O₃ gives rise to photoemission ranging from blue to green-yellow, while air-calcined In₂O₃ shows only blue emission. EPR and optical spectroscopies reveal singly ionized oxygen vacancies induced by H₂ treatment responsible for the green-yellow emission.     

Delays in help seeking at the onset of the symptoms of rheumatoid arthritis: a systematic synthesis of qualitative literature

A systematic review of qualitative peer-reviewed publications was conducted to identify drivers of and barriers to help-seeking behaviour in adults with new-onset rheumatoid arthritis (RA). 1058 abstracts were searched to identify relevant publications. 21 relevant publications were identified assessed for quality and subjected to analysis informed by thematic and grounded theory frameworks. Several interacting themes were identified including the early experience of symptoms in relation to disease prototypes, minimising the impact of symptoms, speaking to others, gathering information and seeking alternative treatments, and issues related to accessing health services and attitudes towards healthcare professionals. Many people suggested that they had little knowledge of RA before diagnosis, believing RA to be a mild condition that affected older people. These misperceptions made correct symptom interpretation unlikely. Normalising and ignoring symptoms led people to delay in help-seeking. However, when symptoms impacted on daily activities help was usually sought. Individual interpretations of symptoms are both drivers of and barriers to help seeking. Targeted public health interventions are required to inform symptom interpretation and reduce delays.     

Obesity and Cardiovascular Disease Risk Factors among the Indigenous and Immigrant Pakistani Population: A Systematic Review

AimThe aim of this study was to systematically describe the gender and ethnic differences regarding the prevalence of general/central obesity and cardiovascular disease (CVD) risk factors such as diabetes mellitus type 2, hypertension, and hypercholesterolemia among the indigenous and immigrant Pakistani communities.MethodsThe search engine used was PubMed, supplemented with regional data from the Medical Institutes of Pakistan. The focus was on the adult Pakistani population (18 years and older).ResultsWe found only 7 studies among the immigrant Pakistani community and 24 studies among the indigenous Pakistani community. The studies had limitations such as low participation rates and use of self-reported data. There is a higher prevalence of central obesity among women (42.2%) than among men (14.7%) (National Health Survey of Pakistan). Certain ethnicities such as Muhajir and Baluchis showed a higher prevalence of cardiovascular risk factors when compared to other ethnicities in the indigenous Pakistani population. The results also indicate that the prevalence of obesity is 10-20% higher among the immigrant Pakistanis than in the indigenous Pakistanis.ConclusionThe relatively high prevalence of obesity and associated CVD risk factors (especially in women) among both indigenous and immigrant Pakistani populations require the attention of the healthcare professionals and policy makers, both inside and outside Pakistan.Key Words: Cardiovascular diseases, Obesity, Diabetes, Hypertension, Hypercholesterolemia, Pakistanis     

Progressive ataxia associated with ocular apraxia type 1 (AOA1) with a presence of a novel mutation on the aprataxin gene

Ataxia, although rare, can be a symptom of many debilitating movement disorders. Hereditary ataxias are one subset of this condition and manifest when there is a genetic abnormality involved. Ataxia oculomotor apraxia type 1 (AOA1), an autosomal recessive ataxia, results from a mutation on the aprataxin gene (APTX). We characterized a novel homozygous deletion mutation (IVS4-12delT) on the APTX gene in a 14-year-old male born to consanguineous parents. This case report emphasizes the importance of investigating and increasing awareness of novel genetic mutations in order to help diagnose and further classify hereditary ataxias.     

Sole abnormalities of chromosome 7 in myeloid malignancies: spectrum, histopathologic correlates, and prognostic implications

Among 6,565 consecutive abnormal cytogenetic reports at our institution, 3,192 (49%) constituted sole abnormalities, of which 230 (7%) involved chromosome 7: monosomy 7 (n = 98), 7q- (n = 51), der(1;7)(q10;p10) (n = 44), balanced translocations (n = 15), ring 7 (n = 13), and 7p- (n = 9). The most frequent histopathologic correlates were myelodysplastic syndromes (MDS; 28%), acute myeloid leukemia (AML; 17%), secondary or therapy-related MDS/AML (13%), primary myelofibrosis (PMF; 7%), and chronic myelomonocytic leukemia (6%). Monosomy 7 was the most frequent in each one of these disease categories except PMF where 7q- was more frequent. In primary MDS, patients with der(1;7)(q10;p10) (n = 13), compared to those with monosomy 7 (n = 30) or 7q- (n = 15), were less likely (P = 0.04) to display excess blasts or multilineage dysplasia but overall and leukemia-free survival adjusted for these variables revealed no significant difference between the three groups (P = 0.57 and 0.81, respectively). The current study does not prognostically distinguish monosomy 7 from 7q- or der(1;7), in MDS.