Design,synthesis, and evaluation of a series of novel phenylpropanoic acid derivatives agonists for the FFA1

Free fatty acid 1 (FFA1/GPR40) has attracted extensive attention as a novel target for the treatment of type 2 diabetes for its role in the enhancement of insulin secretion with glucose dependency. Aiming to develop novel potent FFA1 agonists, a new series of phenylpropionic acid derivatives were designed and synthesized on the basis of the modification of chemical cement of TAK‐875, AMG‐837, and LY2881835. Among them, most promising compounds 7 , 14 , and 15 were obtained with EC₅₀ values of 82, 79, and 88 nM, exhibiting a powerful agonistic activity compared to TAK‐875 (95.1 nM). During Oral glucose tolerance test in normal mice, compound 7 , 14 , and 15 had significant glucose‐lowering effect at the dose of 50 mg/kg. Furthermore, compound 15 (50 mg/kg) also significantly improved in glucose tolerance in type 2 diabetic mice. Herein, we reported the discovery and optimization of a series of potent FFA1 agonists. The discovery supported further exploration surrounding this scaffold.     

用谐波小波包变换法提取GIS局部放电信号多尺度特征参数

超高频(UHF)法在GIS局部放电(PD)检测中已得到了广泛应用，UHF PD信号的特征提取对准确识别GIS内部绝缘缺陷类型和指导检修工作具有重要意义，但目前仍然缺乏有效的特征提取方法。为此，本文利用谐波小波具有严格盒形频谱的优点，提出一种提取UHF PD特征信息的谐波小波包变换(HWPT)方法，对实验室获取的4种典型放电模型产生的UHF PD信号，采用HWPT进行多尺度分解，以克服实小波包分解子带间存在频谱混叠和能量泄漏的缺陷，利用UHF PD信号在不同尺度能量和复杂度的差异，提取多尺度能量和多尺度样本熵参数作为模式识别的特征量，更加精确地描述了UHF PD信号的时频域信息。最后利用支持向量机分类识别的结果表明，该方法可以取得比实小波包更好的识别效果，多尺度能量和多尺度样本熵特征参数均能有效识别4种绝缘缺陷。     

腹腔镜乙状结肠癌伴降结肠系膜旋转不良一例报道

降结肠系膜旋转不良（PDM）是由降结肠与腹膜后融合不全引起的，PDM通常无症状。然而，降结肠系膜旋转不良、乙状结肠向右侧与回盲部的先天粘连以及肠系膜下动脉的解剖变异等均可能会对结直肠癌的手术决策及难易度产生影响。我们报道一例乙状结肠癌伴肝转移瘤合并PDM的诊治，对其腹腔镜手术治疗的体会及注意要点加以阐述。     

Role of phytoestrogens in prevention and management of type 2 diabetes

Type 2 diabetes(T2D)has become a major public health threat across the globe.It has been widely acknowledged that diet plays an important role in the development and management of T2D.Phytoestrogens are polyphenols that are structurally similar to endogenous estrogen and have weak estrogenic properties.Emerging evidence from pre-clinical models has suggested that phytoestrogens may have anti-diabetic function via both estrogendependent and estrogen-independent pathways.In the current review,we have summarized the evidence linking two major types of phytoestrogens,isoflavones and lignans,and T2D from epidemiological studies and clinical trials.The cross-sectional and prospective cohort studies have reported inconsistent results,which may due to the large variations in different populations and measurement errors in dietary intakes.Long-term intervention studies using isoflavone supplements have reported potential beneficial effects on glycemic parameters in postmenopausal women,while results from short-term smallsize clinical trials are conflicting.Taken together,the current evidence from different study designs is complex and inconsistent.Although the widespread use of phytoestrogens could not be recommended yet,habitual consumption of phytoestrogens,particularly their intact food sources like soy and whole flaxseed,could be considered as a component of overall healthy dietary pattern for prevention and management of T2D.     

Emergence of a virulent porcine reproductive and respiratory syndrome virus in Taiwan in 2018

In March 2018, an abortion storm caused by porcine reproductive and respiratory syndrome virus was confirmed in a farrow‐to‐finish pig herd in Taiwan. Open reading frame 5 and non‐structural protein 2 of the virus confirmed that the virus is closely related to the virulent strains circulating in the United States.     

冠状动脉支架术治疗48例冠心病临床疗效分析

目的探讨冠状动脉支架术治疗冠心病的临床效果。方法对48例冠心病患者行冠状动脉支架术,并进行2年随访,了解治疗效果。结果 48例接受冠状动脉支架手术治疗的患者中46例患者心绞痛症状得到有效缓解,复发时间延长,治疗有效,有效率95.83%。2例患者治疗无效。结论冠状动脉支架术对于冠心病患者的心绞痛症状有很好的缓解作用,且手术的安全性较高。     

不良孕产史夫妇染色体核型的大样本分析

目的探讨不良孕产史夫妇染色体异常核型检出率及其分布，以及染色体异常核型与不良孕产史的关系，为优生优育及遗传咨询提供理论依据。 方法选取2016年1月1日至2017年12月31日，于济南艾迪康医学检验中心进行染色体核型检测的10 330对(20 660例)不良孕产史育龄夫妇为研究对象。采集每例受试者肘静脉血3 mL，肝素钠抗凝，取0.3 mL进行血细胞培养、标本制备，采用常规G显带技术进行染色体核型分析。对于染色体异常核型检出率、不同类型染色体异常核型占染色体异常核型总例数的比例等计数资料，采用率(%)表示。本研究遵循的程序符合2013年修订的《世界医学协会赫尔辛基宣言》要求。 结果①本组10 330对(20 660例)不良孕产史育龄夫妇中，共计检出染色体异常核型为1 119例(不含染色体多态性)，染色体异常核型检出率为5.42%(1 119/20 660)。其中，常染色体异常者为658例，占染色体异常核型的58.80%(658/1 119)，包括354例染色体平衡易位、205例染色体倒位、83例染色体罗伯逊易位、11例染色体插入、5例染色体重复，分别占染色体异常核型的31.64%、18.32%、7.41%、0.98%、0.45%。染色体倒位者中，以9号染色体倒位居多，偶见于1、4、7、11、12号染色体，并且多合并自然流产。性染色体异常者为440例，占染色体异常核型的39.32%(440/1 119)，包括365例性染色体数目异常(占染色体异常核型的32.62%)。其中，男性多表现为无精子症，以47，XXY染色体异常核型居多(144例)，女性多表现为原发性不孕，以45，X染色体异常核型居多(103例); 61例为性染色体结构异常、14例为性别反转，分别占染色体异常核型的5.45%、1.25%。其他罕见染色体异常核型者为21例，占染色体异常核型的1.88%(21/1 119)，如环状染色体、mar染色体等。②本组10 330对(20 660例)不良孕产史育龄夫妇中，11例为常染色体插入，5例为常染色体重复，54例为性染色体缺失，其主要临床表现为原发性不孕不育、胚胎停止发育、无精子症或重度少精子症。 结论染色体异常核型是导致育龄期夫妇不良孕产史的重要原因之一。对于不良孕产史夫妇，建议进行染色体核型分析和遗传咨询。临床为这类患者进行优生优育指导，可提高出生人口质量。     

ICRU89号报告的解读——放射物理篇

本篇综述对ICRU89号报告的放射物理相关内容进行了详细解读,希望为从事宫颈癌近距离放射治疗的同仁在放射物理相关方面提供借鉴。