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11.
MALDI mass sequencing and biochemical characterization of Setaria cervi protein tyrosine phosphatase
Reeta Rai Neetu Singh Srikanth Elesela Savitri Tiwari Sushma Rathaur 《Parasitology research》2013,112(1):147-154
A 30-kDa acid phosphatase with protein tyrosine phosphatase activity was identified in Setaria cervi (ScPTP). The enzyme was purified to homogeneity using three-step column chromatography. Matrix-assisted laser desorption/ionization-time of flight (MALDI-TOF) analysis of purified ScPTP yielded a total of eight peptides matching most closely to phosphoprotein phosphatase of Ricinus communis (RcPP). A hydrophilicity plot of RcPP revealed the presence of these peptides in the hydrophilic region, suggesting their antigenic nature. The substrate specificity of ScPTP with ortho-phospho-l-tyrosine and inhibition with sodium orthovanadate and ammonium molybdate affirmed it as a protein tyrosine phosphatase. ScPTP was also found to be tartrate resistant. The Km and Vmax were 6.60 mM and 83.3 μM/ml/min, respectively, with pNPP and 8.0 mM and 111 μM/ml/min, respectively, with ortho-phospho-l-tyrosine as the substrate. The Ki value with sodium orthovanadate was calculated to be 16.10 mM. Active site modification with DEPC, EDAC and pHMB suggested the presence of histidine, cysteine and aspartate at its active site. Thus, on the basis of MALDI-TOF and biochemical studies, it was confirmed that purified acid phosphatase is a PTP. 相似文献
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Aanchal Satija Suraj Pal Singh Komal Kashyap Sushma Bhatnagar 《Indian Journal of Palliative Care》2014,20(2):153-156
Pain due to cancer is one of the most distressing symptoms experienced by the patients at some or the other time during the course of treatment or disease progression. The multidimensional nature of cancer pain is characterized by various dimensions including physical, social, psychological, and spiritual; which together constitute the term “total pain”. Young cancer patients illustrate their unique psychological and developmental needs. This case report highlights the concept of “total cancer pain” in a young adult and demonstrates his distinctive social, spiritual, and psychological sufferings. The report emphasizes that addressing all these concerns is considerably significant in order to provide optimal pain relief to the patient. In the present scenario, it has been done by a skillful multiprofessional team communicating effectively with both the patient and the carer. 相似文献
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Background
Perinatal asphyxia is known to precipitate myocardial dysfunction, rhythm abnormalities and congestive cardiac failure.Case characteristics
A 2-day old neonate with perinatal asphyxia.Observation
He developed shock secondary to ventricular tachycardia, and required synchronized cardioversion for reversion of abnormal rhythm.Outcome
Reversal of arrhythmia leading to recovery.Message
Early identification and management of ventricular tachycardia in neonate with perinatal asphyxia can be lifesaving. 相似文献15.
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Bansal VK Misra MC Chaubal G Datta Gupta S Das B Ahuja V Sagar S 《Indian journal of gastroenterology》2012,31(2):57-60
Background
Helicobacter species have been found to be associated with biliary tract diseases. This prospective study was done to determine the prevalence of H. pylori in the biliary tract of patients suffering from gallbladder disease.Methods
Forty-nine patients undergoing laparoscopic/open cholecystectomy for benign biliary tract diseases were investigated with urea breath test for H. pylori infection of gastric antrum. Bile and gallbladder tissues were studied for presence of H. pylori by rapid urease test, histopathological examination, culture and PCR analysis. Gallbladder specimens from two patients who underwent Whipple??s operation and from 10 cadavers were studied as controls.Results
The mean (SD) age of patients was 42.4 (11.1) years. Urea breath test was positive in 17 (34.6%) cases. Rapid urease test was negative in all the cases. There was no evidence of H. pylori infection of gallbladder on histopathological examination using H&;E, Giemsa and Warthin Starry stains. H. pylori DNA were detected in 16 patients (32.6%) and none of the 12 controls by PCR analysis (p?=?0.025). The presence of H. pylori DNA in bile and/or gallbladder was associated with positive urea breath test, (p?0.0001). Other factors like age, gender, jaundice and cholestasis were not associated with H. pylori infection of bile and gallbladder.Conclusions
Nearly three quarters of patients with positive urea breath test have detectable H. pylori DNA in gallbladder tissue. The significance of these findings needs to be further evaluated. 相似文献19.
Sanjay Balaji Lagdive Sushma Sanjay Lagdive 《Journal of Indian Prosthodontic Society》2013,13(4):450-454
Dental implantology is the state of the art technique to replace missing teeth. Implant stability of implant jeopardizes its longevity and success of treatment. This study evaluates the implant stability of implant before and after 4 months of the implant placement, but before prosthetically loading it. Ten two-stage implants of Life care and Nobel Biocare dental implants were placed in 20 patients. Digital OPG was taken on the day of implant placement. After 4 months, at the time of second stage surgery, the implant stability was evaluated by the Periotest instrument. Four months after the implant placement, Periotest evaluation showed a mean of 1.9, which indicated that implants were well osseointegrated and stable. Even before prosthetically loading the two-stage implant, crestal bone loss of 0.6–0.9 mm occurred around the implant. The smooth polished collar design of the implant may have contributed to crestal bone loss. 相似文献
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