全文获取类型
收费全文 | 5336篇 |
免费 | 372篇 |
国内免费 | 21篇 |
专业分类
耳鼻咽喉 | 23篇 |
儿科学 | 165篇 |
妇产科学 | 131篇 |
基础医学 | 825篇 |
口腔科学 | 188篇 |
临床医学 | 399篇 |
内科学 | 1276篇 |
皮肤病学 | 223篇 |
神经病学 | 573篇 |
特种医学 | 85篇 |
外科学 | 429篇 |
综合类 | 24篇 |
预防医学 | 461篇 |
眼科学 | 151篇 |
药学 | 391篇 |
中国医学 | 36篇 |
肿瘤学 | 349篇 |
出版年
2023年 | 45篇 |
2022年 | 85篇 |
2021年 | 194篇 |
2020年 | 119篇 |
2019年 | 191篇 |
2018年 | 205篇 |
2017年 | 145篇 |
2016年 | 183篇 |
2015年 | 181篇 |
2014年 | 246篇 |
2013年 | 283篇 |
2012年 | 489篇 |
2011年 | 478篇 |
2010年 | 263篇 |
2009年 | 204篇 |
2008年 | 389篇 |
2007年 | 316篇 |
2006年 | 301篇 |
2005年 | 311篇 |
2004年 | 285篇 |
2003年 | 238篇 |
2002年 | 263篇 |
2001年 | 24篇 |
2000年 | 25篇 |
1999年 | 40篇 |
1998年 | 36篇 |
1997年 | 28篇 |
1996年 | 21篇 |
1995年 | 15篇 |
1994年 | 10篇 |
1993年 | 13篇 |
1992年 | 11篇 |
1991年 | 10篇 |
1990年 | 7篇 |
1989年 | 5篇 |
1988年 | 6篇 |
1987年 | 7篇 |
1986年 | 7篇 |
1984年 | 3篇 |
1983年 | 4篇 |
1982年 | 6篇 |
1981年 | 4篇 |
1980年 | 3篇 |
1978年 | 3篇 |
1976年 | 2篇 |
1974年 | 4篇 |
1972年 | 2篇 |
1971年 | 2篇 |
1970年 | 2篇 |
1967年 | 2篇 |
排序方式: 共有5729条查询结果,搜索用时 312 毫秒
61.
Andrea Corrales Paula Martínez Susana García Verónica Vidal Eva García Jesús Flórez Emilio J. Sanchez‐Barceló Noemí Rueda 《Journal of pineal research》2013,54(3):346-358
Ts65Dn mice (TS), the most commonly used model of Down syndrome (DS), exhibit phenotypic characteristics of this condition. Both TS mice and DS individuals present cognitive disturbances, age‐related cholinergic degeneration, and increased brain expression of β‐amyloid precursor protein (AβPP). These neurodegenerative processes may contribute to the progressive cognitive decline observed in DS. Melatonin is a pineal indoleamine that has been reported to reduce neurodegenerative processes and improve cognitive deficits in various animal models. In this study, we evaluated the potentially beneficial effects of long‐term melatonin treatment on the cognitive deficits, cholinergic degeneration, and enhanced AβPP and β‐amyloid levels of TS mice. Melatonin was administered for 5 months to 5‐ to 6‐month‐old TS and control (CO) mice. Melatonin treatment improved spatial learning and memory and increased the number of choline acetyltransferase (ChAT)‐positive cells in the medial septum of both TS and CO mice. However, melatonin treatment did not significantly reduce AβPP or β‐amyloid levels in the cortex or the hippocampus of TS mice. Melatonin administration did reduce anxiety in TS mice without inducing sensorimotor alterations, indicating that prolonged treatment with this indoleamine is devoid of noncognitive behavioral side effects (e.g., motor coordination, sensorimotor abilities, or spontaneous activity). Our results suggest that melatonin administration might improve the cognitive abilities of both TS and CO mice, at least partially, by reducing the age‐related degeneration of basal forebrain cholinergic neurons. Thus, chronic melatonin supplementation may be an effective treatment for delaying the age‐related progression of cognitive deterioration found in DS. 相似文献
62.
Susana Helm Scott K Okamoto Jay Maddock Donald Hayes Tonya Lowery Ranjani Rajan 《Hawai'i Journal of Medicine & Public Health》2013,72(2):66-69
This article briefly outlines a collaboration among communities on Hawai‘i Island and a university-based research team to develop, implement, and evaluate a school-based substance use prevention curriculum called Ho‘ouna Pono. In addition to providing a rationale for the project, the goal of this paper is fourfold. First, an overview of the Ho‘ouna Pono research results to date (2007–2013) is provided. Second, within this overview, the ways in which selected results informed program development are highlighted. Third, the curriculum is briefly described, and finally, the role of the students and community in the video production is described. 相似文献
63.
Karmele Valencia Marta Martín-Fernández Carolina Zandueta Cristina Ormazábal Susana Martínez-Canarias Eva Bandrés Concepción de la Piedra Fernando Lecanda 《BONE》2013,52(1):532-539
Recent evidence suggests that miRNAs could be used as serum markers in a variety of normal and pathological conditions. In this study, we aimed to identify novel miRNAs associated with skeletal metastatic disease in a preclinical model of lung cancer bone metastasis. We assessed the validity of these miRNAs as reliable serum biochemical markers to monitor the extent of disease and response to treatment in comparison to imaging techniques and standard biochemical markers of bone turnover. Using a murine model of human lung cancer bone metastasis after zoledronic acid (ZA) treatment, PINP (procollagen I amino-terminal propeptide) was the only marker that exhibited a strong correlation with osteolytic lesions and tumor burden at early and late stages of bone colonization. In contrast, BGP (osteocalcin) and CTX (carboxyterminal telopeptide) demonstrated a strong correlation only at late stages. We performed qPCR based screening of a panel of 380 human miRNAs and quantified bone metastatic burden using micro-CT scans, X-rays and bioluminescence imaging. Interestingly, levels of miR-326 strongly associated with tumor burden and PINP in vehicle-treated animals, whereas no association was found in ZA-treated animals. Only miR-193 was associated with biochemical markers PINP, BGP and CTX in ZA-treated animals. Consistently, miR-326 and PINP demonstrated a strong correlation with tumor burden. Our findings, taken together, indicate that miR-326 could potentially serve as a novel biochemical marker for monitoring bone metastatic progression. 相似文献
64.
Isabel García-López Susana Santiago-Pérez Julio Peñarrocha-Teres Antonio J. del Palacio Javier Gavilan 《Acta otorrinolaringologica espanola》2012,63(6):458-464
Introduction and objectivesLaryngeal electromyography, together with clinical evaluation, is a valuable tool in voice disorder management. It assesses the integrity of laryngeal nerves and muscles, contributing to the diagnosis of many diseases, especially laryngeal movement disorders. Our purpose was to describe the experience of the first Spanish series with laryngeal electromyography in evaluating voice disorders.MethodsA prospective study was designed to evaluate laryngeal movement disorders with laryngeal electromyography. Both the cricothyroid and thyroarytenoid muscles were tested routinely and, in some cases, the posterior cricoarytenoid muscle. The laryngeal electromyography technique and result interpretation were performed by a laryngologist and a neurophysiologist.ResultsWe included 110 patients, with the most common symptom being dysphonia. Laryngeal electromyography was performed in 85% of cases. Primary diagnosis before electromyography was laryngeal immobility. Positive predictive value for diagnosis in cases of paralysis was 88%.ConclusionsLaryngeal electromyography is a useful adjunct, together with clinical evaluation, for diagnosis and management of motion abnormalities in the larynx in patients who present with dysphonia. 相似文献
65.
66.
Sol Esteves Diana Andrea Ramirez Romero Teresa Torralva Macarena Martínez Cuitiño Shannon Herndon Blas Couto 《Neurocase》2018,24(1):16-30
Posterior cortical atrophy (PCA) is a rare neurodegenerative syndrome characterized by initial predominant visuoperceptual deficits followed by a progressive decline in other cognitive functions. This syndrome has not been as thoroughly described as other dementias, particularly from a neuropsychological evolution perspective with only a few studies describing the evolution of its cognitive progression. In this investigation we review the literature on this rare condition and we perform a 7-year neuropsychological and neuroradiological follow-up of a 64-year-old man with PCA. The subject’s deficits initially appeared in his visuoperceptual skills with later affectation appearing in language and other cognitive functions, this being coherent with the patient’s parieto-temporal atrophy evolution. 相似文献
67.
José M. Cimadevilla Lola Roldán María París Marisa Arnedo Susana Roldán 《Journal of clinical and experimental neuropsychology》2014,36(9):1002-1008
Very preterm births prevent a complete development of the nervous system. The hippocampus is especially vulnerable in this population since the perinatal period is critical for its growth and development. Learning and memory abilities, like spatial memory, depend on the hippocampal integrity. In this study we applied virtual-reality-based tasks to assess spatial memory in a sample of 20 very preterm children of 7 and 8 years of age. Two different conditions of difficulty were used. Very preterm children performed poorly in the task in comparison with the control group. They committed more errors than controls searching for the rewarded positions. However, no significant differences were observed in the mean speed, an index of the motor abilities and joystick handling. These results suggest that the hippocampal function is affected in this sample. Nevertheless, other variables to consider are discussed. 相似文献
68.
Maria Isabel Fernández-San-Martín Luis Miguel Martín-López Roser Masa-Font Noemí Olona-Tabueña Yuani Roman Jaume Martin-Royo Silvia Oller-Canet Susana González-Tejón Luisa San-Emeterio Albert Barroso-Garcia Lidia Viñas-Cabrera Gemma Flores-Mateo 《Community mental health journal》2014,50(1):81-95
Patients with severe mental illness have higher prevalences of cardiovascular risk factors (CRF). The objective is to determine whether interventions to modify lifestyles in these patients reduce anthropometric and analytical parameters related to CRF in comparison to routine clinical practice. Systematic review of controlled clinical trials with lifestyle intervention in Medline, Cochrane Library, Embase, PsycINFO and CINALH. Change in body mass index, waist circumference, cholesterol, triglycerides and blood sugar. Meta-analyses were performed using random effects models to estimate the weighted mean difference. Heterogeneity was determined using i2 statistical and subgroups analyses. 26 studies were selected. Lifestyle interventions decrease anthropometric and analytical parameters at 3 months follow up. At 6 and 12 months, the differences between the intervention and control groups were maintained, although with less precision. More studies with larger samples and long-term follow-up are needed. 相似文献
69.
70.