全文获取类型
| 收费全文 | 4372526篇 |
| 免费 | 350918篇 |
| 国内免费 | 14708篇 |
专业分类
| 耳鼻咽喉 | 60634篇 |
| 儿科学 | 140651篇 |
| 妇产科学 | 115080篇 |
| 基础医学 | 669892篇 |
| 口腔科学 | 118256篇 |
| 临床医学 | 401839篇 |
| 内科学 | 794153篇 |
| 皮肤病学 | 108049篇 |
| 神经病学 | 370485篇 |
| 特种医学 | 170029篇 |
| 外国民族医学 | 753篇 |
| 外科学 | 658297篇 |
| 综合类 | 121628篇 |
| 现状与发展 | 24篇 |
| 一般理论 | 2676篇 |
| 预防医学 | 362717篇 |
| 眼科学 | 101200篇 |
| 药学 | 309576篇 |
| 25篇 | |
| 中国医学 | 11975篇 |
| 肿瘤学 | 220213篇 |
出版年
| 2021年 | 56341篇 |
| 2020年 | 35969篇 |
| 2019年 | 59027篇 |
| 2018年 | 74700篇 |
| 2017年 | 56964篇 |
| 2016年 | 63061篇 |
| 2015年 | 75916篇 |
| 2014年 | 110289篇 |
| 2013年 | 176088篇 |
| 2012年 | 126531篇 |
| 2011年 | 131767篇 |
| 2010年 | 126712篇 |
| 2009年 | 128224篇 |
| 2008年 | 117699篇 |
| 2007年 | 125281篇 |
| 2006年 | 133926篇 |
| 2005年 | 128069篇 |
| 2004年 | 129258篇 |
| 2003年 | 119366篇 |
| 2002年 | 108474篇 |
| 2001年 | 167247篇 |
| 2000年 | 162252篇 |
| 1999年 | 148882篇 |
| 1998年 | 71822篇 |
| 1997年 | 67734篇 |
| 1996年 | 65741篇 |
| 1995年 | 61133篇 |
| 1994年 | 55053篇 |
| 1993年 | 51087篇 |
| 1992年 | 106734篇 |
| 1991年 | 101512篇 |
| 1990年 | 97344篇 |
| 1989年 | 94912篇 |
| 1988年 | 87263篇 |
| 1987年 | 85417篇 |
| 1986年 | 80303篇 |
| 1985年 | 78440篇 |
| 1984年 | 65477篇 |
| 1983年 | 58264篇 |
| 1982年 | 47244篇 |
| 1981年 | 43906篇 |
| 1980年 | 41117篇 |
| 1979年 | 55155篇 |
| 1978年 | 44819篇 |
| 1977年 | 40012篇 |
| 1976年 | 36874篇 |
| 1975年 | 36848篇 |
| 1974年 | 39667篇 |
| 1973年 | 37794篇 |
| 1972年 | 35396篇 |
排序方式： 共有10000条查询结果，搜索用时 15 毫秒
941.
Michael M Gezalian Luigi Mangiacotti Padmesh Rajput Nicklaus Sparrow Konrad Schlick Shouri Lahiri 《Journal of cerebral blood flow and metabolism》2021,41(4):693
Adrenoceptor and calcium channel modulating medications are widely used in clinical practice for acute neurological and systemic conditions. It is generally assumed that the cerebrovascular effects of these drugs mirror that of their systemic effects – and this is reflected in how these medications are currently used in clinical practice. However, recent research suggests that there are distinct cerebrovascular-specific effects of these medications that are related to the unique characteristics of the cerebrovascular anatomy including the regional heterogeneity in density and distribution of adrenoceptor subtypes and calcium channels along the cerebrovasculature. In this review, we critically evaluate existing basic science and clinical research to discuss known and putative interactions between adrenoceptor and calcium channel modulating pharmacotherapies, the neurovascular unit, and cerebrovascular anatomy. In doing so, we provide a rationale for selecting vasoactive medications based on lesion location and lay a foundation for future investigations that will define neuroprotective paradigms of adrenoceptor and calcium channel modulating therapies to improve neurological outcomes in acute neurological and systemic disorders. 相似文献
942.
B. Midouni E. Mehiri A. Ghariani H. Draoui L. Essalah I. Bouzouita D. Raoult L. Slim-Saidi P.E. Fournier 《International journal of antimicrobial agents》2019,53(1):63-69
Objectives
This study aimed to explore the genetic diversity of Streptococcus pneumoniae isolates in a Tunisian pneumology hospital.Methods
A total of 141 S. pneumoniae strains isolated between 2009–2016 in the microbiology laboratory at A. Mami Hospital of Pneumology were investigated. Antimicrobial susceptibility testing was performed the disk diffusion method. MICs of penicillin G, amoxicillin and cefotaxime were determined by Etest. Serotyping was inferred from the results of multiplex PCR targeting 40 serotypes. Sequence types (STs) were determined by multilocus sequence typing (MLST).Results
Among the 141 S. pneumoniae isolates, 98 (69.5%) were resistant to erythromycin. Evaluation of β-lactam susceptibility showed that 90 strains (63.8%) were non-susceptible to penicillin, whereas 48 (34.0%) had decreased susceptibility to amoxicillin and 21 (14.9%) to cefotaxime. Twenty-five serotypes were detected, and 10 isolates were classified as non-typeable. Vaccine coverage was 56.7%, 60.3% and 75.2% for pneumococcal conjugate vaccine 7 (PCV7), PCV10 and PCV13, respectively. Overall, 73 STs were identified, including 23 described for the first time. The most frequent STs were ST179 (n?=?17), ST3772 (n?=?14), ST2918 (n?=?10) and ST4003 (n?=?5), related to serotypes 19F, 19A, 14 and 23F, respectively. Moreover, 110 strains were classified within 45 STs. Three international antimicrobial-resistant clones were found, including Denmark14-ST230 (n?=?22), Spain9V-ST156 (n?=?22) and Portugal19F-ST177 (n?=?20).Conclusion
This study emphasises the clonal and international dissemination of antimicrobial-resistant S. pneumoniae clones. Significant differences in genetic variation were documented by MLST within the various serotypes identified. 相似文献943.
944.
945.
946.
947.
目的 探析正念减压疗法对妊娠呕吐妇女负性情绪和生活质量的影响。 方法 将2017年5月-2018年5月在我院治疗的90例妊娠呕吐妇女纳入本研究,采用数字表法随机分成研究组和对照组,每组各45例。对照组接受宣教,研究组在对照组上实施正念减压疗法。分别于入组时、干预4周和干预8周采用焦虑自评量表(self-rating anxiety scale,SAS)、抑郁自评量表(self-rating depression scale,SDS)、生活质量综合评定问卷(generic quality of life inventory-74,GQOLI-74)进行评估,比较2组妊娠呕吐妇女负性情绪和生活质量。 结果 2组SAS、SDS评分及生活质量综合评定问卷总分在组间效应、时间效应及交互效应上差异具统计学意义。 结论 妊娠呕吐妇女进行正念减压疗法,能够显著减轻妊娠呕吐妇女负性情绪和提高生活质量,值得在临床上广泛应用。 相似文献
948.
Sebastian Mondaca Walid K. Chatila David Bates Jaclyn F. Hechtman Andrea Cercek Neil H. Segal Zsofia K. Stadler Anna M. Varghese Ritika Kundra Marinela Capanu Jinru Shia Nikolaus Schultz Leonard Saltz Rona Yaeger 《Clinical colorectal cancer》2019,18(1):e39-e52
Background
Treatment of advanced anal squamous cell cancer (SCC) is usually with the combination of cisplatin and 5-fluorouracil, which is associated with heterogeneous responses across patients and significant toxicity. We examined the safety and efficacy of a modified schedule, FOLFCIS (leucovorin, fluorouracil, and cisplatin), and performed an integrated clinical and genomic analysis of anal SCC.Patients and Methods
We reviewed all patients with advanced anal SCC receiving first-line FOLFCIS chemotherapy – essentially a FOLFOX (leucovorin, fluorouracil, and oxaliplatin) schedule with cisplatin substituted for oxaliplatin – in our institution between 2007 and 2017, and performed deep sequencing to identify genomic markers of response and key genomic drivers.Results
Fifty-three patients with advanced anal SCC (48 metastatic; 5 unresectable, locally advanced) received first-line FOLFCIS during this period; all were platinum-naive. The response rate was 48% (95% confidence interval [CI], 32.6%-63%). With a median follow-up of 41.6 months, progression-free survival and overall survival were 7.1 months (95% CI, 4.4-8.6 months) and 22.1 months (95% CI, 16.9-28.1 months), respectively. Among all patients with advanced anal SCC that underwent sequencing during the study period, the most frequent genomic alterations consisted of chromosome 3q amplification (51%) and mutations in PIK3CA (29%) and KMT2D (22%). No genomic alteration correlated with response to platinum-containing treatment. Although there were few cases, patients with human papillomavirus-negative anal SCC did not appear to benefit from FOLFCIS, and all harbored distinct genomic profiles with TP53, TERT promoter, and CDKN2A mutations.Conclusions
FOLFCIS appears effective and safe as first-line chemotherapy in patients with advanced anal SCC and represents an alternative treatment option for these patients. 相似文献949.
Oga Emmanuel. A. Peters Erica. N. Mark Katrina Trocin Kathleen Coleman-Cowger Victoria. H. 《Maternal and child health journal》2019,23(2):250-257
Maternal and Child Health Journal - Background Prenatal substance use screening is recommended. The 4 P’s Plus screener includes questions on perceived problematic substance use in parents... 相似文献