Treatment of generalized suppurative peritonitis]

In the period from 1980 to 1986 fifty-nine patients were treated for generalized purulent peritonitis of 72-hour duration. The traditional methods of therapy were applied--removal of the source of peritonitis and drainage of the abdominal cavity. The mortality was 62.7%. Since 1987, peritoneal lavage with enteral administration of oxygenized 5% glucose solution is used in the treatment of patients with generalized peritonitis in the stage of poly-organic insufficiency. Peritoneal-enteral lavage was applied in the management of 41 patients, 10 of them died. The mortality was 36.5%. The efficacy of the method was judged on basis of bacteriological study, electroenterography, and functional tests for the absorptive capacity of the small intestine. The results of stage peritoneal lavage and the findings of bacteriological study lead to the conclusion that it is extremely dangerous to postpone repeated cleansing of the abdominal cavity in such patients because progressive deterioration of the condition with a fatal outcome occurs in this case. Cleansing of the abdominal cavity must be accomplished during the first lavage or 24 hours later during relaparotomy and no hope should be entertained that inadequate cleansing will be compensated for during subsequent relaparotomies.     

Complexes of dihydroquercetin with chromium (III) and zinc (II) asparaginates in water and their effects on the state of lecithin membranes

The formation of chelate complexes of dihydroqercetin (DHQ) with zinc and chromium asparaginates in aqueous solution is established and their interaction with a lecithin monolayer is estimated. On the basis of analysis of the surface pressure-molecular area isotherms, it is concluded that an increase in the molecular area from 0.54 to 0.80–0.90 nm 2 is indicative of the immobilization of DHQ complexes in the lecithin monolayer. It is shown that the concentration of the initial products of lipid peroxidacion-diene and triene conjugates-decreases to 24 % and 41 %, respectively, and that of the final products (Schiff bases) in the blood of patients treated by Oftalvit (containing DHQ and metal asparaginates) decreases to 46 % in comparison to values in the control groups. Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 42, No. 10, pp. 14–20, October, 2008.