全文获取类型
收费全文 | 654387篇 |
免费 | 56146篇 |
国内免费 | 42599篇 |
专业分类
耳鼻咽喉 | 5466篇 |
儿科学 | 7759篇 |
妇产科学 | 8056篇 |
基础医学 | 71944篇 |
口腔科学 | 10997篇 |
临床医学 | 90434篇 |
内科学 | 88536篇 |
皮肤病学 | 6921篇 |
神经病学 | 31578篇 |
特种医学 | 24840篇 |
外国民族医学 | 366篇 |
外科学 | 59282篇 |
综合类 | 118148篇 |
现状与发展 | 137篇 |
一般理论 | 69篇 |
预防医学 | 47297篇 |
眼科学 | 18775篇 |
药学 | 69652篇 |
651篇 | |
中国医学 | 41244篇 |
肿瘤学 | 50980篇 |
出版年
2024年 | 1889篇 |
2023年 | 8551篇 |
2022年 | 22608篇 |
2021年 | 28882篇 |
2020年 | 22407篇 |
2019年 | 18751篇 |
2018年 | 19813篇 |
2017年 | 18807篇 |
2016年 | 17539篇 |
2015年 | 26872篇 |
2014年 | 33928篇 |
2013年 | 31163篇 |
2012年 | 46049篇 |
2011年 | 53761篇 |
2010年 | 35359篇 |
2009年 | 28203篇 |
2008年 | 35164篇 |
2007年 | 34957篇 |
2006年 | 34387篇 |
2005年 | 33927篇 |
2004年 | 26453篇 |
2003年 | 24942篇 |
2002年 | 20458篇 |
2001年 | 17419篇 |
2000年 | 16579篇 |
1999年 | 17189篇 |
1998年 | 10683篇 |
1997年 | 10363篇 |
1996年 | 8004篇 |
1995年 | 7314篇 |
1994年 | 6302篇 |
1993年 | 4768篇 |
1992年 | 5425篇 |
1991年 | 4646篇 |
1990年 | 3802篇 |
1989年 | 3179篇 |
1988年 | 2750篇 |
1987年 | 2401篇 |
1986年 | 1922篇 |
1985年 | 1408篇 |
1984年 | 847篇 |
1983年 | 595篇 |
1982年 | 330篇 |
1981年 | 351篇 |
1980年 | 255篇 |
1979年 | 353篇 |
1978年 | 143篇 |
1977年 | 118篇 |
1974年 | 128篇 |
1973年 | 103篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
101.
No impact of repeated endoscopic screens on gastric cancer mortality in a prospectively followed Chinese population at high risk. 总被引:6,自引:0,他引:6
B Riecken R Pfeiffer J L Ma M L Jin J Y Li W D Liu L Zhang Y S Chang M H Gail W C You 《Preventive medicine》2002,34(1):22-28
BACKGROUND: Gastric cancer (GC) is the leading cause of cancer deaths in China. Our study prospectively evaluated the impact of repeated endoscopic screens on GC mortality in a high-risk population in China. METHODS: Between 1989 and 1999, a population-based gastroscopic screening was conducted in 4,394 residents of Linqu County, China, a region with the highest rates of GC worldwide. Residents ages 35 to 64 years received initial gastroscopies with biopsies in 1989. Repeated endoscopies were performed in 1994 and 1999. Cancer occurrences and deaths were actively monitored throughout the entire period until July 2000. Mortality from GC was compared with expected values based on mortality rates obtained for Linqu in the 1990-1992 Chinese Cancer Mortality Survey. RESULTS: Between March 1989 and July 2000, 39,303 person-years were accumulated; 85 new GCs occurred, 29 (34.5%) were in early stage. Fifty-eight cases (68%) were identified at one of the screens. The number of observed deaths from GC (37) was close to the expected (36.8). The standardized mortality ratio was 1.01 (95% CI 0.72-1.37) for the entire cohort, 1.13 (95% CI 0.77-1.57) for males, and 0.65 (95% CI 0.26-1.32) for females. CONCLUSIONS: Despite high population coverage with repeated screens, no reduction in GC mortality was observed in this high-risk population in China. 相似文献
102.
李永光 《中国民族医药杂志》2005,11(6):21-21
蒙医学在长期的临床实践中总结和探索出较为科学的毒性药物炮制、制剂配伍和应用方法,使毒性药物在临床得到极为广泛的应用。特别是蒙药一般选用生药、多复方、用量小、服用方法简便、起效迅速,其作用较等量中药制剂强而有力,其中重要原因之一就是蒙医学擅长使用毒性药物及峻烈药材,以毒攻毒,多有奇效。成方中含有毒药物的方剂比率较高,据《蒙医成方选》一书记载:解痉镇痛药全部8个配方,白喉肿毒治疗药配方24个中有20个, 相似文献
103.
Geert Verreck Annelies Decorte Koen Heymans Jef Adriaensen Dirk Cleeren Adri Jacobs Dehua Liu David Tomasko Albertina Arien Jef Peeters Patrick Rombaut Guy Van den Mooter Marcus E Brewster 《European journal of pharmaceutical sciences》2005,26(3-4):349-358
The aim of the current research project was to explore the possibilities of combining pressurized carbon dioxide with hot stage extrusion during manufacturing of solid dispersions of itraconazole and polyvinylpyrrolidone-co-vinyl acetate 64 (PVP-VA 64) and to evaluate the ability of the pressurized gas to act as a temporary plasticizer as well as to produce a foamed extrudate. Pressurized carbon dioxide was injected into a Leistritz Micro 18 intermeshing co-rotating twin-screw melt extruder using an ISCO 260D syringe pump. The physicochemical characteristics of the extrudates with and without injection of carbon dioxide were evaluated with reference to the morphology of the solid dispersion and dissolution behaviour and particle properties. Carbon dioxide acted as plasticizer for itraconazole/PVP-VA 64, reducing the processing temperature during the hot stage extrusion process. Amorphous dispersions were obtained and the solid dispersion was not influenced by the carbon dioxide. Release of itraconazole from the solid dispersion could be controlled as a function of processing temperature and pressure. The macroscopic morphology changed to a foam-like structure due to expansion of the carbon dioxide at the extrusion die. This resulted in increased specific surface area, porosity, hygroscopicity and improved milling efficiency. 相似文献
104.
One of the consequences of increased intracellular calcium in response to a variety of physiological stimuli is the calcium activation of cytosolic proteases. Unlike lysosomal proteases with broad specificity, these calcium-activated neutral proteases show limited proteolysis of a restricted set of substrate proteins suggesting they may play a regulatory role in cellular physiology. In this study we show that the neural cell adhesion molecules NCAM-180 and N-cadherin are substrates for such endogenous calcium-activated neutral proteases. In contrast, a third neural cell adhesion molecule G4/L1 was not susceptible to calcium-activated proteolysis. The threshold for activation of NCAM and N-cadherin proteolysis is in the micromolar range of calcium suggesting that NCAM and N-cadherin are substrates for a mu-type calpain (calpain I). The site recognized by this protease is within intracellular domains of NCAM-180 and N-cadherin which are important for their interaction with cytoskeletal components. These results suggest that calcium-activated proteolysis at these sites in vivo could disrupt the linkage between extracellular ligand binding to these adhesion molecules and the normal intracellular effectors of such extracellular binding events. 相似文献
105.
白纹伊蚊在竹林里孳生的阳性比为75.4%;而在竹林包围的居民区阳性比为15.3%。白纹伊蚊在居民区孳生密度布雷图指数为19.4,容器指数为6.2%。居民区孳生蚊虫的主要场所是泡菜坛,泡菜坛主要孳生蚊种是骚扰阿蚊,阳性比为73.7%,其次是淡色库蚊为20.2%,贪食库蚊为14.0%,白纹伊蚊最低,为9.1%。 相似文献
106.
目的分析各种因素对手工凝聚胺试验的影响;方法应用手工凝聚胺(manual polgbrene test,MPT)做交叉配血及抗体筛选试验;结果血液标本、操作手法、凝聚胺试剂、药物(肝素、止血敏、高浓度KCl等)等对试验均有影响;其中以药物、操作手法影响较大,可致假阴性和假阳性结果;结论手工凝聚胺试验做交叉配血及抗体筛选时应注意排除药物和操作手法对试验结果的影响。 相似文献
107.
The neuroprotective effects of dizocilipine maleate (MK-801), a noncompetitive antagonist of the N-methyl-D-aspartate (NMDA) receptor/channel, were tested in the 4-vessel occlusion rat model of forebrain ischemia. Adult Wistar rats, treated intraperitoneally with MK-801 or saline using several different treatment paradigms were subjected to 5 (n = 208) or 15 (n = 62) min of severe, transient forebrain ischemia. In saline-treated animals, 15 min of ischemia (n = 13) produced extensive and consistent loss of pyramidal neurons in the CA1 zone of hippocampus. The degree and distribution of cell loss were not reduced by single dose preischemic administration of MK-801 at 1 (n = 7), 2.5 (n = 4), or 5 mg/kg (n = 8). In other animals subjected to 15 min of forebrain ischemia, multiple doses of MK-801 (5, 2.5, and 2.5 mg/kg) given immediately and at approximately 8 and 20 hr after cerebral reperfusion (n = 5) did not alter CA1 injury compared to saline-treated controls (n = 5). Five minutes of forebrain ischemia in saline-treated animals, (n = 82) resulted in significantly fewer (p less than 0.001) dead CA1 pyramidal cells and a greater variance compared to animals subjected to 15 min of ischemia. Power analysis of the preliminary saline-treated animals subjected to 5 min of ischemia (n = 22) indicated that 60 animals per group were necessary to detect a 15% difference between MK-801 and vehicle-treated groups. Multidose treatment with MK-801 (1 mg/kg) given 1 hr prior to 5 min of ischemia (n = 60) and again at approximately 8 and 16 hr after recirculation failed to attenuate hippocampal injury.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
108.
109.
本文对95例肾病综合征进行分析,探讨了性别、年龄、发病迁延时间、浮肿、蛋白尿、血尿、血压、尿素氮、血浆蛋白、血浆胆固醇、免疫球蛋白、补体C_3与激素反应及分型的关系。认为下列综合分析可做为判定难治性肾病综合征的参考。难治性肾病多分布在7岁以上,激素治疗4~8周血浆蛋白尚未恢复,尿镜检反复出现红细胞及颗粒管型,血清r—球蛋白不低,而补体C_3降低,提示难治性肾病。各种感染常常是造成肾病综合心难以控制,甚至死亡的重要因素。 相似文献
110.
Campylobacter jejuni cultured in a candle jar 总被引:3,自引:0,他引:3