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41.
Cervantes M Zhou H Sahin A Dhingra K Valero V Ordonez N Elnaggar A Hess K Glassman A Sen S 《International journal of oncology》1995,6(5):955-962
Correlation of p53 gene/protein alterations with incidence of oncogene amplification, a potential marker of prognosis, was evaluated in 26 fresh breast cancer samples. p53 gene was analyzed by SSCP and DNA sequencing while p53 protein status was investigated by immunohistochemistry (IH). Amplification of c-erbB2/neu, c-myc, N-ras, int-2, hst, PRAD-1 and EGFR genes was studied by slot blot and in situ hybridizations. p53 alterations were found in 31% cases by SSCP and 42% by IH; gene amplification was detected in 27% cases. p53 gene alterations correlated significantly with gene amplification (p=0.006) and also with higher S-phase index (p=0.026), aneuploidy (p=0.026) and negative progesterone receptor status (p=0.043). 相似文献
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PreliminaryevaluationofpelvicvascularbedisolationchemotherapyinthetreatmentofadvancedcervicalcarcinomaJiangSenandPostgraduate... 相似文献
43.
Khatri ML Shafi M Sen NK 《Indian journal of dermatology, venereology and leprology》1996,62(5):322-324
A 24-year old male patient developed multiple lesions of keratoacanthoma in the epidermal verrucous naevus. He also had multiple papillomatous lesions on the lips, buccal mucosa, gingiva and tongue, with positive family history of similar lesions. He also had multiple skin tags and patchy palmoplantar keratoderma and minimal kyphoscoliosis. 相似文献
44.
Urken ML Catalano PJ Sen C Post K Futran N Biller HF 《Archives of otolaryngology--head & neck surgery》1993,119(12):1318-1325
OBJECTIVE: The role of free flaps in skull base reconstruction is discussed in detail. Twenty-six microvascular free tissue transfers performed in 22 patients are reviewed in detail. A classification scheme for skull base defects is presented. SETTING: Tertiary referral center. PATIENTS: Twenty-two patients with neoplasms that involve the skull base underwent a combined craniotomy and facial approach for resection. The resultant defects were reconstructed with a variety of microvascular free flaps. RESULTS: All 22 patients were ultimately successfully reconstructed with a free flap. One patient required a second free flap following ablative surgery for a recurrent tumor. The initial free flaps in three patients were unsuccessful and a second flap was required. The classification scheme was applied to all defects. CONCLUSIONS: The creation of a functional separation of the intracranial and extracranial cavities can be extremely difficult to accomplish, especially when multiple cavities (nasal, oral, pharyngeal) are violated. Free flaps provide a solution to this problem in select cases. Skull base defects can and should be classified for the purpose of communication, treatment planning, prognosis of reconstruction, and judging therapeutic outcome. 相似文献
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Tarr RW Jungreis CA Horton JA Pentheny S Sekhar LN Sen C Janecka IP Yonas H 《Skull base surgery》1991,1(4):240-244
Treatment of some tumors and aneurysms of the skull base may require internal carotid artery (ICA) sacrifice. Preoperatively to determine the dependence of the cerebral blood flow on a particular vessel, we perform a balloon test occlusion (BTO) by temporarily occluding the vessel in an awake patient. During occlusion, clinical evaluations and cerebral blood flow measurements are assessed. We have performed 300 BTOs. Eleven patients (3.7%) have had complications. Six (2%) were asymptomatic dissections. Five (1.7%) had neurologic deficits that persisted beyond the test period. Of these five, one was back to baseline in less than 24 hours, one recovered completely in a week, and one (0.33%) had a minimal but persistent dysphasia. These latter three cases are unexplained but might have resulted from unrecognized dissections or embolic events. Finally, one patient with a persistent deficit required energency surgery for reasons unrelated to the BTO and was therefore difficult to assess, and one required emergency middle cerebral artery embolectomy and repair of the dissection. The preoperative knowledge of carotid dependence in cases in which the ICA is at risk is essential, since vascular grafts or alternative surgical approaches are necessary in patients unable to tolerate carotid sacrifice. Since approximately 15 to 20% of the population falls into this category, a preoperative BTO appears justified. 相似文献
48.
肝癌和肝硬化患者血清一氧化氮水平探讨 总被引:1,自引:0,他引:1
目的:探讨一氧化氮(NO)与肝癌及其合并症、肝硬化、肝功能分级及肝硬化并发症的关系。方法:应用化学比色法检测34例肝癌患者,45例肝硬化患者及20例正常人血清NO水平。结果:肝癌组血清NO显著高于肝硬化组及正常对照组;肝癌合并代偿期肝硬化血清NO高于合并慢性肝炎者;肝硬化组血清NO与正常对照组比较,差异有显著性;并且随肝功能Child-Pugh分级的增加而升高,A级与对照组比较无差异,B级与A级、B级与C级比较,差异有显著性。并发肝肾综合征、食管胃底静脉曲张破裂出血者较无并发症肝硬化者NO明显升高。结论:内源性NO在肝癌及肝硬化时合成增加,且与肝癌合并症、肝硬化病情严重程度及并发症的发生密切相关。血清NO测量有助于肝癌及肝硬化病情的临床评估及疗效观察。 相似文献
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正交设计法考察盐酸洛美沙星葡萄糖注射液制备工艺 总被引:4,自引:0,他引:4
目的:对盐酸洛美沙星葡萄糖注射液生产工艺过程的影响因素进行实验考察,寻求最佳生产工艺。方法:通过正交设计考察pH、加炭量、温度和加热时间4个因素对盐酸洛美沙星含量的影响,选用L16(4^5)正交表进行实验。结果:实验证明活性炭对盐酸洛美沙星有明显吸附作用,在pH值为4.8,加炭量为0.02%,温度为50℃及加热时间为10 min的优化条件下,活性炭对盐酸洛美沙星的吸附量最小。结论:生产过程中应对上述影响因素进行控制,提高产品质量。 相似文献