全文获取类型
收费全文 | 9229篇 |
免费 | 417篇 |
国内免费 | 55篇 |
专业分类
耳鼻咽喉 | 51篇 |
儿科学 | 186篇 |
妇产科学 | 80篇 |
基础医学 | 1138篇 |
口腔科学 | 268篇 |
临床医学 | 633篇 |
内科学 | 2913篇 |
皮肤病学 | 204篇 |
神经病学 | 522篇 |
特种医学 | 308篇 |
外科学 | 1423篇 |
综合类 | 27篇 |
一般理论 | 1篇 |
预防医学 | 336篇 |
眼科学 | 113篇 |
药学 | 701篇 |
中国医学 | 12篇 |
肿瘤学 | 785篇 |
出版年
2022年 | 93篇 |
2021年 | 140篇 |
2020年 | 97篇 |
2019年 | 105篇 |
2018年 | 148篇 |
2017年 | 120篇 |
2016年 | 141篇 |
2015年 | 142篇 |
2014年 | 162篇 |
2013年 | 234篇 |
2012年 | 343篇 |
2011年 | 417篇 |
2010年 | 219篇 |
2009年 | 189篇 |
2008年 | 405篇 |
2007年 | 430篇 |
2006年 | 395篇 |
2005年 | 421篇 |
2004年 | 419篇 |
2003年 | 367篇 |
2002年 | 407篇 |
2001年 | 304篇 |
2000年 | 306篇 |
1999年 | 266篇 |
1998年 | 107篇 |
1997年 | 87篇 |
1996年 | 91篇 |
1995年 | 78篇 |
1994年 | 83篇 |
1993年 | 85篇 |
1992年 | 283篇 |
1991年 | 237篇 |
1990年 | 196篇 |
1989年 | 243篇 |
1988年 | 215篇 |
1987年 | 224篇 |
1986年 | 219篇 |
1985年 | 191篇 |
1984年 | 122篇 |
1983年 | 101篇 |
1982年 | 52篇 |
1981年 | 49篇 |
1979年 | 86篇 |
1978年 | 53篇 |
1977年 | 49篇 |
1975年 | 43篇 |
1972年 | 47篇 |
1971年 | 45篇 |
1969年 | 46篇 |
1968年 | 45篇 |
排序方式: 共有9701条查询结果,搜索用时 15 毫秒
31.
32.
33.
34.
Y Nomura S Miura H Koyama K Enomoto F Kasumi H Yamamoto M Kimura T Tominaga H Iino T Morimoto 《Cancer》1992,69(1):153-164
In a retrospective multicenter study to investigate the correlation between estrogen (ER) and/or progesterone receptors (PgR) in primary breast cancer with patient prognosis, 3118 patients with operable breast cancer (International Union Against Cancer Stages I, II, and III) were investigated from ten hospitals in Japan who underwent surgery from October 1972 to December 1982; 3089 were evaluable. The ER-positive and PgR-positive cancers were found in 56% and 34% of patients, respectively. The positivities decreased as the tumor size increased but were independent on lymph node metastasis. There were no significant differences in relapse-free survival (RFS) in relation to receptor status (median follow-up, 89 months [ER], 84 months [PgR]). However, in patients with four or more positive nodes, those with PgR-positive cancer had a longer RFS. The patients with ER-positive cancer survived significantly longer than ER-negative ones, with the greatest difference seen in those with four or more positive nodes. There was a significantly longer postrelapse survival (PRS) for patients with ER-positive cancer because of the different distribution of the major metastasis and better responses to first-line and subsequent treatments. Cox's multivariate analysis showed that overall survival but not PRS was affected by ER (and more weakly by PgR) because of the longer PRS in patients with ER-positive cancer. 相似文献
35.
36.
The activity of phrenic motor neurons is influenced by the cardiovascular control system of the supraspinal structures. In order to obtain the basic data for analyzing the anatomical relations between the cardiovascular and the pulmonary control system, supraspinal structures projecting to the phrenic motor nucleus of the cat spinal cord were studied using a horseradish peroxidase method. A double-barrel coaxial electrode was employed. To determine the site of the phrenic motor neurons, the inner barrel electrode, filled with 3 M NaCl solution, was used for recording the activity of these neurons. The outer barrel electrode, filled with a 20% HRP solution, was used for injecting HRP iontophoretically into the phrenic motor nucleus. Out of 13 experiments, 5 showed that the HRP-injection sites were centered in and almost confined to the phrenic motor nucleus. Some 1798 HRP-labeled cells were thus identified in the selected 5 experiments. They were distributed in the medulla oblongata (93.5%), pons (6.0%) and midbrain (0.5%). The majority were concentrated in the nucleus para-ambiguus (48.9%), nucleus tractus solitarii (21.5%) and in or around the nucleus retrofacialis (9.8%). A few labeled cells were scattered throughout the nucleus raphe (1.1%) and the parabrachial and Koelliker-Fuse nuclei (0.3%), suggesting that these nuclei may be, if any, only minor sources of input to the phrenic motor nucleus. 相似文献
37.
H Shiozaki T Ide J Nakao T Imamura M Nakamura K Shimada Y Miura T Suda 《Japanese journal of cancer research》1992,83(5):499-504
LD78 is a cDNA newly isolated from human stimulated tonsillar lymphocytes. The expression of LD78 is related to inflammatory responses and its structure has a homology with macrophage inflammatory protein 1-alpha, which is known to have an inhibitory effect on murine CFU-S. Using a colony assay technique, we examined the effects of LD78 on human hemopoietic progenitors. The addition of doses of 100 ng/ml or more of LD78 suppressed the colony formation of KMT-2, a factor-dependent myelomonocytic cell line established from cord blood cells; this suppressive activity was neutralized by the addition of antibody against LD78. The same doses of LD78 suppressed the formation of neutrophil, macrophage, and megakaryocytic colonies which were supported by human interleukin-3 and erythropoietin; however, LD78 did not affect colony formation by either non-phagocytic mononuclear cells or sorted CD34+ cells. The conditioned medium of KMT-2 cells or peripheral blood mononuclear cells cultured with LD78 suppressed colony formation by CD34+ cells. From these findings, it is suggested that LD78 affects phagocytic cells and induces factors that are inhibitory for hemopoiesis. We consider LD78 to be a new cytokine that plays an inhibitory role in hemopoiesis. 相似文献
38.
K Ishii M Oda S Kazemoto T Azuma H Kaneko H Yokomori H Saitoh S Miura M Tsuchiya 《Nihon Shokakibyo Gakkai zasshi》1992,89(2):552-557
39.
Late Effects of Childhood Acute Leukemia and Its Treatment 总被引:1,自引:0,他引:1
Masao Yamamoto M.D. Yoshitaka Fukunaga M.D. Ichiroh Tsukimoto M.D. Fumio Bessho M.D. Jun-ichi Akatsuka M.D. Ryohta Hosoya M.D. Shinpei Nakazawa M.D. Minoru Sakurai M.D. Kazuhiro Ueda M.D. Sumio Miyazaki M.D. Masaru Yokoyama M.D. Hideo Mugishima M.D. Kohzoh Nishimura M.D. 《Pediatrics international》1991,33(4):573-588
Late effects of childhood acute leukemia and its treatment were studied in 766 patients (684 ALL, 73 ANLL, and 9 others) in Japan who had remained in remission for more than 1 year after their first complete remission. Delayed adverse sequelae involve a wide variety of organs and their functions. Short stature was present in 2.61%, obesity in 3.79%, abnormalities of growth hormone secretion in 1.5%, delayed secondary sex characteristics in 1.5% of males and 0.6% of females, motor disturbances in 1.17%, sensory disturbances in 0.91%, intellectual and learning disabilities in 2.48%, abnormal findings in routine neurologic examinations in 1.31%, EEG abnormalities in 4.30%, brain CT abnormalities in 5.09% and cardiac dysfunction in 1.07%. Various other disorders were seen in 20 patients. Many of these delayed adverse sequelae are caused by or related to central nervous system prophylaxis and systemic combination chemotherapy. The results suggest that it is needed to improve therapeutic methods through the stratification of patients by risk factors and detailed analysis of prognostic factors. Moreover it is important to render medical and psychosocial support to long-term survivors of childhood leukemia through interactions between the patient, parents and medical staff. 相似文献
40.
K Takaori T Takeda H Yamada K Miura T Yukimura F Ikemoto K Yamamoto 《Japanese circulation journal》1988,52(11):1346-1350
Plasma immunoreactive renin was measured by sandwich radioimmunoassay, under various physiological and pathological conditions. Enzymatic activities of active renin and trypsin-activatable inactive renin were also measured. There was a significant correlation between plasma immunoreactive renin concentration (IRRC) and total (active plus inactive) renin concentration, as estimated by enzymatic activity. In plasma from normotensive volunteers and hypertensive patients, the IRRC were 279 +/- 37 pg/ml and 268 +/- 29 pg/ml, respectively. After the intravenous injection of furosemide, the plasma IRRC in normotensive volunteers increased significantly. IRRC was significantly higher in plasma from juvenile diabetics than in plasma from age-matched disease-free children. Thus, renin secretion in children with diabetes mellitus is increased. 相似文献