全文获取类型
收费全文 | 6532篇 |
免费 | 349篇 |
国内免费 | 182篇 |
专业分类
耳鼻咽喉 | 121篇 |
儿科学 | 128篇 |
妇产科学 | 119篇 |
基础医学 | 1111篇 |
口腔科学 | 105篇 |
临床医学 | 558篇 |
内科学 | 1180篇 |
皮肤病学 | 239篇 |
神经病学 | 440篇 |
特种医学 | 718篇 |
外科学 | 776篇 |
综合类 | 41篇 |
一般理论 | 3篇 |
预防医学 | 235篇 |
眼科学 | 124篇 |
药学 | 507篇 |
1篇 | |
中国医学 | 44篇 |
肿瘤学 | 613篇 |
出版年
2023年 | 27篇 |
2022年 | 89篇 |
2021年 | 159篇 |
2020年 | 84篇 |
2019年 | 123篇 |
2018年 | 154篇 |
2017年 | 130篇 |
2016年 | 159篇 |
2015年 | 224篇 |
2014年 | 264篇 |
2013年 | 356篇 |
2012年 | 490篇 |
2011年 | 475篇 |
2010年 | 280篇 |
2009年 | 272篇 |
2008年 | 352篇 |
2007年 | 423篇 |
2006年 | 294篇 |
2005年 | 296篇 |
2004年 | 235篇 |
2003年 | 250篇 |
2002年 | 211篇 |
2001年 | 214篇 |
2000年 | 198篇 |
1999年 | 143篇 |
1998年 | 128篇 |
1997年 | 113篇 |
1996年 | 93篇 |
1995年 | 77篇 |
1994年 | 57篇 |
1993年 | 63篇 |
1992年 | 50篇 |
1991年 | 55篇 |
1990年 | 46篇 |
1989年 | 71篇 |
1988年 | 58篇 |
1987年 | 55篇 |
1986年 | 37篇 |
1985年 | 29篇 |
1984年 | 27篇 |
1983年 | 17篇 |
1982年 | 28篇 |
1981年 | 17篇 |
1980年 | 17篇 |
1979年 | 16篇 |
1978年 | 10篇 |
1977年 | 19篇 |
1976年 | 30篇 |
1975年 | 13篇 |
1974年 | 9篇 |
排序方式: 共有7063条查询结果,搜索用时 15 毫秒
41.
T H Lim J S Lee B I Choi I O Kim C H Suh M C Han C W Kim 《Journal of computer assisted tomography》1987,11(3):474-479
The pattern of renal enhancement and washout of contrast medium was observed on sequential follow-up CT in 12 patients with Korean hemorrhagic fever, in which acute renal failure is one of the most important clinical features. Renal contrast enhancement and contrast medium washout were delayed longer in patients with severe oliguric renal failure. The delayed washout peaked at 4-5 days and did not return to normal until 8-9 days in the patients with severe oliguria; in the patients without severe oliguria the times were 1-2 days and 3-4 days, respectively. A characteristic "cart-wheel" pattern was observed during the washout stage in patients without severe oliguria. This "cart-wheel" pattern of washout is thought to result from relief of vasoconstriction and repair of tubular function. Multifocal "wedge-shaped" nonenhanced areas of the kidney, seen on the 2 week follow-up postcontrast CT, are thought to be ischemic zones due to persistent vasoconstriction. On the 6 week follow-up postcontrast CT in one patient, scarring of the kidney was detected in the same area that did not enhance on the 2 week CT. This scarring is thought to be a result of permanent vasoconstriction. 相似文献
42.
43.
Pyoeng Gyun Choe Chang Kyung Kang Hyeon Jeong Suh Jongtak Jung Kyoung-Ho Song Ji Hwan Bang Eu Suk Kim Hong Bin Kim Sang Won Park Nam Joong Kim Wan Beom Park Myoung-don Oh 《Emerging infectious diseases》2021,27(1):327
We investigated the kinetics of severe acute respiratory syndrome coronavirus 2 neutralizing antibodies in 7 asymptomatic persons and 11 patients with pneumonia. The geometric mean titer of neutralizing antibodies declined from 219.4 at 2 months to 143.7 at 5 months after infection, indicating a waning antibody response. 相似文献
44.
Sara Kim Berik Rovgaliyev Jeong-Moo Lee Kwang-Woong Lee Suk Kyun Hong Jae-Hyung Cho Kyung Chul Yoon Nam-Joon Yi Kyung-Suk Suh 《Transplantation proceedings》2021,53(1):200-206
BackgroundSeveral studies have reported that solid organ transplant recipients have a high risk for malignant tumors because the suppressed immune system fails in preventing malignant transformations. De novo malignancy after transplantation is the most common cause of death in the late period after liver transplant (LT). This study investigated the clinical significance of de novo malignancy after LT, and it is the largest study based in Korea to report long-term follow-up results associated with de novo malignancy after LT.MethodsData of 1793 adults who underwent LT in Seoul National University Hospital were retrospectively collected, and medical charts and data from the Ministry of Public Administration and Security were reviewed to examine the causes of death and de novo malignancy status. The Fisher exact test and Kaplan-Meier survival analysis were used to analyze the data.ResultsOf the 1793 recipients, 27 died of de novo malignancies. Of 875 hepatocellular carcinoma (HCC) patients, 12 died, and of 918 non-HCC patients, 15 died. De novo malignancy was the main cause of death at 5 years after LT but was not in the initial 5 years. In Korea the most common cancers that developed after LT were gastric cancer (21.4%) and lymphoma (14.3%). De novo HCC in non-HCC cases was found in 2 patients.ConclusionDe novo malignancy is a key factor affecting long-term survival after LT. Therefore, regular screening and education are important for improving long-term survival and quality of life in these patients after LT. 相似文献
45.
Sarah Suh Emily Hetzel Katie Alter-Troilo Kathleen Lak Jon C. Gould Tammy L. Kindel Rana M. Higgins 《Surgery for obesity and related diseases》2021,17(8):1480-1488
BackgroundPreoperative carbohydrate loading is a component of Enhanced Recovery After Surgery (ERAS) protocols, but there is limited literature in bariatric surgery patients.ObjectivesThe objective of this study was to characterize the impact of preoperative carbohydrate loading on postoperative bariatric surgery outcomes.SettingUniversity Hospital.MethodsPatients undergoing a primary minimally invasive Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy (SG) between 2018 and 2020 were randomized to standard management or intervention. Standard management patients were nothing by mouth (NPO) after midnight prior to surgery. Intervention patients consumed 2 carbohydrate drinks: 1 the night before and another 3 hours prior to surgery. Primary outcomes analyzed included postoperative nausea and vomiting (PONV), length of stay, and overall complications.ResultsIn total, 134 patients were analyzed: 64 intervention (47.8%) and 70 (52.2%) standard. In the end, 7% and 15% of patients were lost to follow-up at 6-weeks and 3-months, respectively. There was no statistically significant difference in length of stay (2.0 ± 1.2 vs 2.1 ± .9 d; P = .65) or postoperative outcomes between the 2 groups. There were no episodes of aspiration among the intervention group. Among RYGB patients, intervention patients had a shorter duration of nausea compared with standard patients. There was no significant difference in glycemic control among patients with and without diabetes.ConclusionsPreoperative carbohydrate drinks can be administered to bariatric surgery patients without significant risks. Carbohydrate loading preoperatively can decrease the duration of PONV in RYGB patients. Carbohydrate drinks can be safely included in bariatric ERAS protocols for patients with and without diabetes, although the benefits remain unknown. 相似文献
46.
GAG-augmented polysaccharide hydrogel: a novel biocompatible and biodegradable material to support chondrogenesis 总被引:29,自引:0,他引:29
Sechriest VF Miao YJ Niyibizi C Westerhausen-Larson A Matthew HW Evans CH Fu FH Suh JK 《Journal of biomedical materials research》2000,49(4):534-541
The quality of articular cartilage engineered using a cell-polymer construct depends, in part, on the chemical composition of the biomaterial and whether that biomaterial can support the chondrocytic phenotype. Acknowledging the supportive influence of tissue-specific matrix molecules on the chondrocytic phenotype, we have combined chondroitin sulfate-A (CSA) and chitosan, a glycosaminoglycan (GAG) analog, to develop a novel biomaterial to support chondrogenesis. Chitosan is a polycationic repeating monosaccharide of beta-1,4-linked glucosamine monomers with randomly located N-acetyl glucosamine units. Chitosan may be combined with the polyanionic CSA such that ionic crosslinking results in hydrogel formation. Bovine primary articular chondrocytes, when seeded onto a thin layer of CSA-chitosan, form discrete, focal adhesions to the material and maintain many characteristics of the differentiated chondrocytic phenotype, including round morphology, limited mitosis, collagen type II, and proteoglycan production. Our findings suggest CSA-chitosan may be well suited as a carrier material for the transplant of autologous chondrocytes or as a scaffold for the tissue engineering of cartilage-like tissue. 相似文献
47.
S S Yoon H D Youn C Suh Y J Bang S J Choi B K Kim N K Kim E C Kim 《Journal of Korean medical science》1987,2(4):255-258
One case of arthritis complicating leukemia is described in which leukemic cells were identified in synovial fluid by light microscopy. Although arthritis is a well-known manifestation of leukemia with an incidence of 13.5%, the pathogenesis often is unclear, and the direct demonstration of leukemic cells in synovial fluid has been very uncommon. A 16 year-old male patient was admitted due to left elbow joint pain and swelling. Synovial fluid examination revealed blast cells and this finding has directed to a final diagnosis of acute lymphoblastic leukemia. 相似文献
48.
Park YH Kim JA Baek JH Jung EJ Kim TH Suh H Park MH Kim KW 《Archives of pharmacal research》1997,20(1):29-33
The effects of ursodeoxycholic acid (UDCA) and its novel derivative, named as HS-1030, on the proliferation of HepG2, human hepatocellular carcinoma cells were investigated. Whereas UDCA had no significant effect in a concentration range we have tested, HS-1030 inhibited the proliferation of HepG2 cells in a concentration dependent manner. Surprisingly, HS-1030 had no effect on the proliferation of Human Chang liver cell which is a normal liver cell line. We also found that proliferation-inhibitory effect of HS-1030 was due to the induction of apoptosis of HepG2 cells, which was confirmed by observing the internucleosomal DNA fragmentation and morphological changes (i.e. cell shrinkage, nuclear condensation and the formation of apoptotic bodies). These results suggest that HS-1030 may be a good candidate as a drug for the treatment of liver cancer. 相似文献
49.
Preclinical evaluation of medical devices (prototype products) offers the opportunity to investigate and study the intended use of device materials. Preclinical evaluation programs are designed to determine the efficacy, safety, and biocompatibility of biomaterials, prostheses, and medical devices. The purpose of safety testing is to determine if a material presents potential harm to the human; it evaluates the interaction of the material with the in vivo environment and determines the effect of the host on the implant. Preclinical evaluation is the determination of the ability of the prototype product to perform with appropriate host response in a specific application, considered from the perspective of human clinical use. Therefore, preclinical data should include materials science and engineering, biology, biochemistry, medicine, host reactions and their evaluation, the testing of biomaterials, and the degradation of materials in a biological environment. 相似文献
50.
Aggressive fibromatosis is a rare benign soft tissue tumor that is difficult to cure because of its infiltrative nature and high tendency to recur locally. The authors retrospectively analyzed 20 patients with histologically-confirmed fibromatosis. All patients underwent surgery with a wide or marginal margin. Five (25%) cases with histologically-negative margins had recurred. External beam radiotherapy was administered to patients whose margins were positive or who had local recurrence. However, out of concern for safety, radiotherapy was not given to two babies and a reproductive-aged woman. The average dose was 5,020 cGy. During the follow-up (mean 32.6 months), all the patients undergoing radiotherapy showed no evidence of local recurrence. A wide local excision has traditionally been the treatment of choice. However, postoperative radiotherapy could be an effective measure for preventing local recurrence in patients with a histologically-positive surgical margin and recurrence independent of any signs of relapse. 相似文献