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排序方式: 共有286条查询结果,搜索用时 15 毫秒
81.
82.
83.
Identification of BRCA1 missense substitutions that confer partial functional activity: potential moderate risk variants?
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84.
TS Papavramidis S Potsi D Paramythiotis A Michalopoulos VN Papadopoulos V Douros A Pantoleon A Foutzila-Kalogera I Ekonomou N Harlaftis 《Journal of Korean medical science》2009,24(6):1216-1219
The present case is one of gallstone obstructive ileus due to gallstones 3 yr after laparoscopic cholecystectomy. It is interesting because of the sex of the patient, the fact that ileus occurred 3 yr after cholecystectomy and that the localization of the obstruction was an old side-to-side ileoileal anastomosis due to a diverticulectomy following intussusception of Meckels'' diverticulum at the age of 3. 相似文献
85.
86.
Yu IT Chiu YL Wong TW Tang JL 《International archives of occupational and environmental health》2004,77(7):499-504
Objective: Previous studies have shown that waiters have a high risk of developing cancers of the buccal cavity and pharynx, but nasopharyngeal cancer (NPC) has not been specifically studied. This study was carried out to investigate whether waiters/waitresses in Chinese restaurants have an increased risk of dying from NPC. Methods: A mortality odds ratio study was used to estimate the relative risk of dying from NPC for waiters/waitresses working in Chinese restaurants in Hong Kong during the period 1986–1995, using the general population as the external comparison group and deceased kitchen workers as an internal comparison group. Cases were deaths from NPC and the controls were deaths from the selected sets of reference causes. Results: Seventeen deaths from NPC were identified among 415 deceased waiters and four NPC deaths occurred among 140 deceased waitresses. The adjusted mortality odds ratio (aMOR) for NPC was increased among waiters, being 3.02 (95% CI 1.82–5.00) and 2.61 (95% CI 1.02–6.69) in the external and internal comparisons, respectively. For waitresses, the aMOR was 4.58 (95% CI 1.63–12.86) in the external comparison. Analysis by duration of union membership suggested a dose–response relationship. Conclusions: An increased risk of dying from NPC was observed among waiters/waitresses and could not be fully explained by bias or confounding factors. Possible risk factors related to poor indoor air quality in the service areas of Chinese restaurants in Hong Kong should be further investigated. 相似文献
87.
Ciclopirox is a broad-spectrum antifungal, antibacterial, and anti-inflammatory agent. This open-label study investigated the safety and efficacy of ciclopirox topical suspension 0.77% in the treatment of diaper dermatitis due to Candida albicans (C. albicans). Forty-four male and female subjects aged 6 to 29 months were included in the study. Study medication was applied topically to the affected diaper area twice daily for 1 week. Subjects were clinically evaluated at baseline and days 3, 7, and 14 (7 days post-treatment). Safety and efficacy variables included adverse events, mycological culture studies, KOH tests, Severity Scores, and Global Evaluation of Clinical Response. All adverse events were mild to moderate and considered not related to the study medication. Treatment provided statistically significant improvement (P < .05) for both the rate of mycological cure and reduction of Severity Score at each time point compared with baseline. Ciclopirox was safe and effective in the treatment of diaper dermatitis due to C. albicans. 相似文献
88.
Decreased levels of p26-Bcl-2, but not p30 phosphorylated Bcl-2, precede TGFbeta1-induced apoptosis in colorectal adenoma cells 总被引:1,自引:0,他引:1
Bcl-2 expression is confined to the base of the colonic crypt, whereas
transforming growth factor beta (TGFbeta) is expressed in the upper crypt,
as are the apoptotic death promoters, Bak and Bax. In colonic adenoma
cells, TGFbeta induces a growth arrest. In some adenoma cell lines, this is
accompanied by apoptosis and in others it is not. In this study, we used
two human colonic adenoma cell lines: RG/C2, in which TGFbeta induces a G1
arrest without apoptosis, and BH/C1, in which TGFbeta induces both a G1
arrest and apoptosis. TGFbeta does not induce apoptosis in RG/C2 cells even
if hydrocortisone and insulin are removed from the culture medium. In BH/C1
cells, TGFbeta induces apoptosis in the presence of insulin and
hydrocortisone. Apoptosis induced by TGFbeta is preceded by a reduction in
p26-Bcl-2 protein levels. There was no change in the levels of the p30
phosphorylated form of Bcl-2 or in levels of the proapoptotic proteins Bax
or Bak. RG/C2 cells did not show decreased Bcl-2 levels in response to
TGFbeta- induced growth inhibition. Therefore, TGFbeta regulates Bcl-2
expression in colonic adenoma cells which undergo apoptosis in response to
TGFbeta, but not in those which are growth inhibited, but resistant to
TGFbeta-induced apoptosis. TGFbeta may play an important role in the
colonic epithelium, not only in the inhibition of cell proliferation, but
also in the regulation of apoptosis.
相似文献
89.
Margolis RL; Stine OC; McInnis MG; Ranen NG; Rubinsztein DC; Leggo J; Brando LV; Kidwai AS; Loev SJ; Breschel TS; Callahan C; Simpson SG; DePaulo JR; McMahon FJ; Jain S; Paykel ES; Walsh C; DeLisi LE; Crow TJ; Torrey EF; Ashworth RG; Macke JP; Nathans J; Ross CA 《Human molecular genetics》1996,5(5):607-616
The two most consistent features of the diseases caused by trinucleotide
repeat expansion-neuropsychiatric symptoms and the phenomenon of genetic
anticipation-may be present in forms of dementia, hereditary ataxia,
Parkinsonism, bipolar affective disorder, schizophrenia and autism. To
identify candidate genes for these disorders, we have screened human brain
cDNA libraries for the presence of gene fragments containing polymorphic
trinucleotide repeats. Here we report the cDNA cloning of CAGR1, originally
detected in a retinal cDNA library. The 2743 bp cDNA contains a 1077 bp
open reading frame encoding 359 amino acids. This amino acid sequence is
homologous (56% amino acid identify and 81% amino acid conservation) to the
Caenorhabditis elegans cell fate-determining protein mab-21. CAGR1 is
expressed in several human tissues, most prominently in the cerebellum, as
a message of approximately 3.0 kb. The gene was mapped to 13q13, just
telomeric to D13S220. A 5'-untranslated CAG trinucleotide repeat is highly
polymorphic, with repeat length ranging from six to 31 triplets and a
heterozygosity of 87-88% in 684 chromosomes from several human populations.
One allele from an individual with an atypical movement disorder and
bipolar affective disorder type II contains 46 triplets, 15 triplets longer
than any other allele detected. Though insufficient data are available to
link the long repeat to this clinical phenotype, an expansion mutation of
the CAGR1 repeat can be considered a candidate for the etiology of
disorders with anticipation or developmental abnormalities, and
particularly any such disorders linked to chromosome 13.
相似文献
90.
量子点技术在生物成像中的应用进展 总被引:1,自引:0,他引:1
目的:介绍量子点材料的特点及其在生物成像中的应用,并对其前景进行展望.
资料来源:应用计算机检索PubMed 1998-01/2007-04关于量子点生物成像文章.检索词“quantum dots,biological imaging,bioconjugates,fluorescence imaging”限定文章的语言种类为“English”.
资料选择:对资料进行初审,纳入标准:①量子点的特点及表面修饰.②量子点在不同的生物组织细胞中的成像应用.排除标准:重复性研究.
资料提炼:共收集到符合上述要求的文献31篇,关于量子点的特点及表面修饰的14篇,关于量子点在不同的生物组织细胞中的成像应用17篇.
资料综合:量子点(quantum dots,QDs)是一种新型纳米荧光材料,现有技术能将量子点与生物分子结合在一起作为一种高亮度而稳定的荧光探针用于生物成像.作为一种新型的荧光纳米材料量子点,在多种类型的生物成像研究中较传统的有机荧光素和荧光蛋白而言具有更加优越的特性,使研究者能够以一种全新的方法对单个细胞、组织、甚至活动物的基因、蛋白质和药物靶点进行研究,为疾病机制的阐明和临床诊疗提供有力帮助.
结论:量子点荧光标记材料具有信号稳定、标记简便、检测灵敏的优点,在生物成像中具有良好的应用前景. 相似文献