全文获取类型
收费全文 | 1180139篇 |
免费 | 70527篇 |
国内免费 | 1600篇 |
专业分类
耳鼻咽喉 | 15044篇 |
儿科学 | 32786篇 |
妇产科学 | 27464篇 |
基础医学 | 160099篇 |
口腔科学 | 31101篇 |
临床医学 | 99377篇 |
内科学 | 228726篇 |
皮肤病学 | 20979篇 |
神经病学 | 95299篇 |
特种医学 | 47983篇 |
外国民族医学 | 79篇 |
外科学 | 194091篇 |
综合类 | 21323篇 |
现状与发展 | 1篇 |
一般理论 | 302篇 |
预防医学 | 84713篇 |
眼科学 | 25294篇 |
药学 | 86200篇 |
6篇 | |
中国医学 | 2840篇 |
肿瘤学 | 78559篇 |
出版年
2018年 | 33087篇 |
2017年 | 26289篇 |
2016年 | 30221篇 |
2015年 | 11099篇 |
2014年 | 14599篇 |
2013年 | 20772篇 |
2012年 | 35027篇 |
2011年 | 51097篇 |
2010年 | 36316篇 |
2009年 | 28677篇 |
2008年 | 49685篇 |
2007年 | 54341篇 |
2006年 | 30943篇 |
2005年 | 32135篇 |
2004年 | 32637篇 |
2003年 | 33173篇 |
2002年 | 30228篇 |
2001年 | 55574篇 |
2000年 | 57624篇 |
1999年 | 47716篇 |
1998年 | 11677篇 |
1997年 | 10361篇 |
1996年 | 10254篇 |
1995年 | 9603篇 |
1994年 | 8862篇 |
1993年 | 8082篇 |
1992年 | 35904篇 |
1991年 | 34305篇 |
1990年 | 33118篇 |
1989年 | 32174篇 |
1988年 | 29313篇 |
1987年 | 28538篇 |
1986年 | 26568篇 |
1985年 | 25426篇 |
1984年 | 18119篇 |
1983年 | 15439篇 |
1982年 | 8200篇 |
1981年 | 7065篇 |
1979年 | 15979篇 |
1978年 | 10789篇 |
1977年 | 9179篇 |
1976年 | 8012篇 |
1975年 | 8685篇 |
1974年 | 10558篇 |
1973年 | 9911篇 |
1972年 | 9376篇 |
1971年 | 8868篇 |
1970年 | 8468篇 |
1969年 | 7978篇 |
1968年 | 7235篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
991.
992.
993.
T. A. Fedotcheva N. L. Shimanovskii A. I. Senderovich N. S. Chermnykh A. V. Semeikin V. M. Rzheznikov L. E. Golubovskaya G. S. Grinenko V. V. Banin P. V. Sergeev 《Pharmaceutical Chemistry Journal》2007,41(7):345-349
The hormonal compound with the highest cytostatic activity against MCF-7 tumor cells (human breast cancer, BC) and the lowest
activity against normal cells (rat skin fibroblasts) was sought among gestagens, androstenes, and antiestrogencytostatics.
It was found that antiestrogencytostatics and androstenes had the highest cytostatic activity against tumor cells whereas
gestagens and antiestrogencytostatics were least active against fibroblasts. Studies of the activity of the hormonal compounds
in combination with doxorubicin on the viability of MCF-7 and rat skin fibroblasts found that all investigated compounds with
the exception of dehydroepiandrosterone (DHEA) intensify the cytostatic activity of doxorubicin against tumor cells, the greatest
effect seen for antiestrogencytostatics. A chemoprotective effect of androstenes on normal cells was noted.
__________
Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 41, No. 7, pp. 3–7, July, 2007. 相似文献
994.
Uta Kraus-Tiefenbacher Lelia Bauer Antonella Scheda Carola Schoeber Joerg Schaefer Volker Steil Frederik Wenz 《BMC cancer》2007,7(1):178
Background
For patients suffering of recurrent breast cancer within the irradiated breast, generally mastectomy is recommended. The normal tissue tolerance does not permit a second full-dose course of radiotherapy to the entire breast after a second breast-conserving surgery (BCS). A novel option is to treat these patients with partial breast irradiation (PBI). This approach is based on the hypothesis that re-irradiation of a limited volume will be effective and result in an acceptable frequency of side effects. The following report presents a single center experience with intraoperative radiotherapy (IORT) during excision of recurrent breast cancer in the previously irradiated breast. 相似文献995.
996.
David G Hicks Brian J Yoder Sarah Short Shannon Tarr Nichole Prescott Joseph P Crowe Andrea E Dawson G Thomas Budd Steven Sizemore Muzaffer Cicek Toni K Choueiri Raymond R Tubbs Daniel Gaile Norma Nowak Mary Ann Accavitti-Loper Andra R Frost Danny R Welch Graham Casey 《Clinical cancer research》2006,12(22):6702-6708
PURPOSE: This study aims to determine the effect of loss of breast cancer metastasis suppressor 1 (BRMS1) protein expression on disease-free survival in breast cancer patients stratified by estrogen receptor (ER), progesterone receptor (PR), or HER2 status, and to determine whether loss of BRMS1 protein expression correlated with genomic copy number changes. EXPERIMENTAL DESIGN: A tissue microarray immunohistochemical analysis was done on tumors of 238 newly diagnosed breast cancer patients who underwent surgery at the Cleveland Clinic between January 1, 1995 and December 31, 1996, and a comparison was made with 5-year clinical follow-up data. Genomic copy number changes were determined by array-based comparative genomic hybridization in 47 breast cancer cases from this population and compared with BRMS1 staining. RESULTS: BRMS1 protein expression was lost in nearly 25% of cases. Patients with tumors that were PR negative (P=0.006) or HER2 positive (P=0.039) and <50 years old at diagnosis (P=0.02) were more likely to be BRMS1 negative. No overall correlation between BRMS1 staining and disease-free survival was observed. A significant correlation, however, was seen between loss of BRMS1 protein expression and reduced disease-free survival when stratified by either loss of ER (P=0.008) or PR (P=0.029) or HER2 overexpression (P=0.026). Overall, there was poor correlation between BRMS1 protein staining and copy number status. CONCLUSIONS: These data suggest a mechanistic relationship between BRMS1 expression, hormone receptor status, and HER2 growth factor. BRMS1 staining could potentially be used in patient stratification in conjunction with other prognostic markers. Further, mechanisms other than genomic deletion account for loss of BRMS1 gene expression in breast tumors. 相似文献
997.
Die therapieinduzierte Neutropenie kann mit den Kolonie stimulierenden Faktoren (CSF) der Granulopoese (G-CSF und GM-CSF)
vermieden,abgemildert oder in ihrer Zeitdauer verkürzt werden. Die CSF erm?glichen die Mobilisation h?matopoetischer Stammzellen
in das Blut und deren Sammlung für die Transplantation nach Hochdosistherapie.Diese Faktoren sind daher essenziell in der
Supportivtherapie maligner Erkranklungen. Der Arbeitskreis Supportivma?nahmen in der Onkologie (ASO) der Deutschen Krebsgesellschaft
hat Richtlinien zur Therapie mit den Kolonie stimulierenden Faktoren entwickelt, die unterschiedlichen klinischen Situationen
angepasst sind. Der vollst?ndige Text wurde 12/2001 in “Der Onkologe” publiziert [23], er ist auch auf der Homepage des ASO
unter http://www.onkosupport.de zu finden [24].
Prof.Dr. H. Link H?matologie, Internistische Onkologie, Endokrinologie, Medizinische Klinik I, Westpfalz-Klinikum Kaiserslautern, Akademisches
Lehrkrankenhaus der Johannes-Gutenberg-Universit?t Mainz, 67653 Kaiserslautern, E-Mail: hlink@westpfalz-klinikum.de 相似文献
998.
K Tanaka Y Miyake S Sasaki Y Ohya S Miyamoto I Matsunaga T Yoshida Y Hirota H Oda 《Magnesium research》2006,19(4):268-275
There have only been a few studies on the role of mineral intake in tooth loss. We investigated the association between mineral intake and the prevalence of tooth loss in Japan. We used the baseline data on 1002 pregnant women who were enrolled in the Osaka Maternal and Child Health Study between November 2001 and March 2003. Tooth loss was defined as the previous extraction of one or more teeth. Nutrient intake was assessed by a validated diet history questionnaire. Prevalence odds ratios and confidence intervals were estimated by applying a multiple logistic regression model. The adjusted odds ratio upon comparison of the highest quartile with the lowest quartile of magnesium intake was 0.64 (95% confidence interval, 0.42-0.99), showing a tendency for an inverse dose-response relationship (p for linear trend = 0.05). There were no associations between the level of consumption of calcium, phosphate, iron, zinc, or copper and tooth loss. The present findings suggest that intake of magnesium is related to reduced prevalence of tooth loss among young Japanese women. 相似文献
999.
1000.
Extranodal lymphomas presenting as soft tissue sarcomas to a sarcoma service over a two-year period.
J K O'Neill V Devaraj D A T Silver P Sarsfield C A Stone 《Journal of plastic, reconstructive & aesthetic surgery》2007,60(6):646-654
Non-Hodgkin's lymphoma usually presents with lymphadenopathy at multiple sites but can also involve any part of the musculoskeletal system. Occasionally the presentation is with a soft tissue mass. The presentation of large, superficial lymphomatous masses is similar both clinically and radiologically to that of soft tissue sarcomas. The six cases of lymphoma presenting to the Exeter Sarcoma Service as suspected soft tissue sarcomas, over a two-year period (2002-2004), are presented. We describe the clinical and imaging characteristics of these tumours and their subsequent management. Our cases showed variability in presentation. Only one of the six cases presented with pain and one with tenderness. Four of the cases had no lymphadenopathy and the other two had lymphadenopathy restricted to one nodal basin. Overlying soft tissue swelling occurred in four cases and in distal limb swelling beyond the mass in one case. Radiologically, lymphomas are known to be likely to exhibit confluent lymphadenopathy that is rare in patients with soft tissue sarcoma. Confluent lymphadenopathy was demonstrated in only one case of this series of patients. It is thought that lymphomas infiltrate across anatomical fascial planes more readily than sarcomas and in four of our six cases this feature was present. Clinical history, examination and MRI are insufficient to differentiate between soft tissue sarcoma and lymphoma and the importance of obtaining a pathological diagnosis prior to surgery is clear. It is crucial to differentiate lymphoma from sarcoma in order to avoid unnecessary excisional procedures in lymphoma patients. 相似文献