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151.
Yuni Choi Daniel D. Gallaher Karianne Svendsen Katie A. Meyer Lyn M. Steffen Pamela J. Schreiner James M. Shikany Jamal S. Rana Daniel A. Duprez David R. Jacobs Jr. 《Nutrients》2022,14(3)
To better understand nutrition paradigm shift from nutrients to foods and dietary patterns, we compared associations of a nutrient-based blood cholesterol-lowering diet vs. a food-based plant-centered diet with risk of coronary heart disease (CHD) and stroke. Participants were 4701 adults aged 18–30 years and free of cardiovascular disease at baseline, followed for clinical events from 1985 and 86 to 2018. A plant-centered diet was represented by higher A Priori Diet Quality Score (APDQS). A blood cholesterol-lowering diet was represented by lower Keys Score. Proportional hazards regression was used to calculate hazard ratios (HR). Higher APDQS showed a nutrient-dense composition that is low in saturated fat but high in fiber, vitamins and minerals. Keys Score and APDQS changes were each inversely associated with concurrent plasma low-density lipoprotein cholesterol (LDL-C) change. Over follow-up, 116 CHD and 80 stroke events occurred. LDL-C predicted CHD, but not stroke. APDQS, but not Keys Score, predicted lower risk of CHD and of stroke. Adjusted HRs (95% CIs) for each 1-SD higher APDQS were 0.73 (0.55–0.96) for CHD and 0.70 (0.50–0.99) for stroke. Neither low dietary fat nor low dietary carbohydrate predicted these events. Our findings support the ongoing shift in diet messages for cardiovascular prevention. 相似文献
152.
Philip O. M. Steinhoff Gabriele Uhl Steffen Harzsch Andy Sombke 《The Journal of comparative neurology》2020,528(11):1883-1902
Some animals have evolved task differentiation among their eyes. A particular example is spiders, where most species have eight eyes, of which two (the principal eyes) are used for object discrimination, whereas the other three pairs (secondary eyes) detect movement. In the ctenid spider Cupiennius salei, these two eye types correspond to two visual pathways in the brain. Each eye is associated with its own first- and second-order visual neuropil. The second-order neuropils of the principal eyes are connected to the arcuate body, whereas the second-order neuropils of the secondary eyes are linked to the mushroom body. We explored the principal- and secondary eye visual pathways of the jumping spider Marpissa muscosa, in which size and visual fields of the two eye types are considerably different. We found that the connectivity of the principal eye pathway is the same as in C. salei, while there are differences in the secondary eye pathways. In M. muscosa, all secondary eyes are connected to their own first-order visual neuropils. The first-order visual neuropils of the anterior lateral and posterior lateral eyes are connected with a second-order visual neuropil each and an additional shared one (L2). In the posterior median eyes, the axons of their first-order visual neuropils project directly to the arcuate body, suggesting that the posterior median eyes do not detect movement. The L2 might function as an upstream integration center enabling faster movement decisions. 相似文献
153.
Michael T. Barbe MD Lisa Tonder MS Paul Krack MD PhD Bettina Debû MD Michael Schüpbach MD Steffen Paschen MD Till A. Dembek MD Andrea A. Kühn MD Valerie Fraix MD Christine Brefel-Courbon MD PhD Lars Wojtecki MD PhD David Maltête MD PhD Phillippe Damier MD PhD Friederike Sixel-Döring MD Daniel Weiss MD Marcus Pinsker MD PhD Tatiana Witjas MD PhD Stephane Thobois MD PhD Carmen Schade-Brittinger B.Sc Jörn Rau MSc Jean-Luc Houeto MD PhD Andreas Hartmann MD PhD Lars Timmermann MD PhD Alfons Schnitzler MD PhD Valerie Stoker MPH Marie Vidailhet MD PhD Günther Deuschl MD PhD for the EARLYSTIM study group 《Movement disorders》2020,35(1):82-90
154.
Thomas Pomberger Julia Lschner Steffen R. Hage 《The European journal of neuroscience》2020,52(6):3531-3544
Any transmission of vocal signals faces the challenge of acoustic interferences such as heavy rain, wind, animal or urban sounds. Consequently, several mechanisms and strategies have evolved to optimize signal‐to‐noise ratio. Examples to increase detectability are the Lombard effect, an involuntary rise in call amplitude in response to masking ambient noise, which is often associated with other vocal changes such as call frequency and duration, as well as the animals’ capability of limiting calling to periods where noise perturbation is absent. Previous studies revealed vocal flexibility and various audio‐vocal integration mechanisms in marmoset monkeys. Using acoustic perturbation triggered by vocal behaviour, we investigated whether marmosets are capable of exhibiting changes in call structure when perturbing noise starts after call onset or whether such effects only occur if noise perturbation starts prior to call onset. We show that marmosets are capable of rapidly modulating call amplitude and frequency in response to such noise perturbation. Vocalizations swiftly increased call frequency after noise onset indicating a rapid effect of perturbing noise on vocal motor production. Call amplitudes were also affected. Interestingly, however, the marmosets did not exhibit the Lombard effect as previously reported but decreased call intensity in response to noise. Our findings indicate that marmosets possess a general avoidance strategy to call in the presence of ambient noise and suggest that these animals are capable of counteracting a previously thought involuntary audio‐vocal mechanism, the Lombard effect. These findings will pave the way to investigate the underlying audio‐vocal integration mechanisms explaining these behaviours. 相似文献
155.
Zschoche Marco Emmert Steffen von Bubnoff Nikolas Ranjbar Mahdy Grisanti Salvatore Heindl Ludwig M. Fend Falko Adamietz Irenäus A. Kakkassery Vinodh 《Der Onkologe》2020,26(11):1056-1064
Die Onkologie - Das okuläre Lymphom wird anhand seiner anatomischen Lokalisation in die intraokulären und periokulären Lymphome eingeteilt. Intraokulär kann die Uvea mit ihren... 相似文献
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157.
Hanne C. E. Riekerk Bram F. Coolen Gustav J. Strijkers Allard C. van der Wal Steffen E. Petersen Mary N. Sheppard RoelofJan Oostra Vincent M. Christoffels Bjarke Jensen 《Journal of anatomy》2022,240(2):357
The ventricular walls of the human heart comprise an outer compact layer and an inner trabecular layer. In the context of an increased pre‐test probability, diagnosis left ventricular noncompaction cardiomyopathy is given when the left ventricle is excessively trabeculated in volume (trabecular vol >25% of total LV wall volume) or thickness (trabecular/compact (T/C) >2.3). Here, we investigated whether higher spatial resolution affects the detection of trabeculation and thus the assessment of normal and excessively trabeculated wall morphology. First, we screened left ventricles in 1112 post‐natal autopsy hearts. We identified five excessively trabeculated hearts and this low prevalence of excessive trabeculation is in agreement with pathology reports but contrasts the prevalence of approximately 10% of the population found by in vivo non‐invasive imaging. Using macroscopy, histology and low‐ and high‐resolution MRI, the five excessively trabeculated hearts were compared with six normal hearts and seven abnormally trabeculated and excessive trabeculation‐negative hearts. Some abnormally trabeculated hearts could be considered excessively trabeculated macroscopically because of a trabecular outflow or an excessive number of trabeculations, but they were excessive trabeculation‐negative when assessed with MRI‐based measurements (T/C <2.3 and vol <25%). The number of detected trabeculations and T/C ratio were positively correlated with higher spatial resolution. Using measurements on high resolution MRI and with histological validation, we could not replicate the correlation between trabeculations of the left and right ventricle that has been previously reported. In conclusion, higher spatial resolution may affect the sensitivity of diagnostic measurements and in addition could allow for novel measurements such as counting of trabeculations. 相似文献
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