全文获取类型
收费全文 | 11318篇 |
免费 | 722篇 |
国内免费 | 84篇 |
专业分类
耳鼻咽喉 | 98篇 |
儿科学 | 310篇 |
妇产科学 | 290篇 |
基础医学 | 1615篇 |
口腔科学 | 190篇 |
临床医学 | 944篇 |
内科学 | 2793篇 |
皮肤病学 | 327篇 |
神经病学 | 1027篇 |
特种医学 | 332篇 |
外国民族医学 | 1篇 |
外科学 | 1022篇 |
综合类 | 43篇 |
一般理论 | 2篇 |
预防医学 | 841篇 |
眼科学 | 138篇 |
药学 | 997篇 |
中国医学 | 22篇 |
肿瘤学 | 1132篇 |
出版年
2023年 | 87篇 |
2022年 | 232篇 |
2021年 | 363篇 |
2020年 | 238篇 |
2019年 | 320篇 |
2018年 | 309篇 |
2017年 | 258篇 |
2016年 | 330篇 |
2015年 | 377篇 |
2014年 | 446篇 |
2013年 | 578篇 |
2012年 | 899篇 |
2011年 | 910篇 |
2010年 | 454篇 |
2009年 | 466篇 |
2008年 | 761篇 |
2007年 | 717篇 |
2006年 | 703篇 |
2005年 | 716篇 |
2004年 | 647篇 |
2003年 | 545篇 |
2002年 | 479篇 |
2001年 | 118篇 |
2000年 | 93篇 |
1999年 | 117篇 |
1998年 | 108篇 |
1997年 | 84篇 |
1996年 | 64篇 |
1995年 | 51篇 |
1994年 | 54篇 |
1993年 | 51篇 |
1992年 | 49篇 |
1991年 | 42篇 |
1990年 | 47篇 |
1989年 | 38篇 |
1988年 | 27篇 |
1987年 | 27篇 |
1986年 | 16篇 |
1985年 | 28篇 |
1984年 | 23篇 |
1983年 | 12篇 |
1982年 | 13篇 |
1981年 | 18篇 |
1979年 | 25篇 |
1978年 | 14篇 |
1976年 | 13篇 |
1975年 | 15篇 |
1974年 | 13篇 |
1973年 | 11篇 |
1972年 | 11篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
991.
992.
993.
994.
Giovanni Defazio MD Mar Matarin PhD Elizabeth L. Peckham DO Davide Martino PhD Enza M. Valente PhD Andrew Singleton PhD Anthony Crawley BS Maria Stella Aniello MD Francesco Brancati PhD Giovanni Abbruzzese MD Paolo Girlanda MD Paolo Livrea MD Mark Hallett MD Alfredo Berardelli MD 《Movement disorders》2009,24(4):613-616
We studied the influence of the rs1182 polymorphism of the TOR1A gene on the risk of dystonia spread in two representative cohorts of patients presenting with primary blepharospasm (BSP), one from Italy and the other from the United States of America. The relationship between rs1182 polymorphism and spread was estimated by Kaplan‐Meier survival curves and Cox proportional hazard regression models adjusted by age and sex, age of BSP onset. In both series, patients carrying the T allele (G/T or T/T) in the rs1182 polymorphism were more likely to have dystonia spread as compared with the homozygous carriers of the common G allele. The comparable findings obtained in two independent cohorts support a genetic contribution to BSP spread. © 2009 Movement Disorder Society 相似文献
995.
James Toouli M.D. Ph.D. Lillian Kow M.D. Almino C. Ramos M.D. Franz Aigner M.D. Piet Pattyn M.D. Ph.D. Manoel P. Galvo-Neto M.D. Karl A. Miller M.D. Stefania Romano M.D. Mario Gutierrez M.S.H.S. Jeremy Jokinen Ph.D. 《Surgery for obesity and related diseases》2009,5(5):98-609
BackgroundNo long-term, international, multicenter studies of the effectiveness and safety of the SAGB in morbid obesity have been previously published. The objective of this study was to assess the effectiveness and safety of the Swedish Adjustable Gastric Band (SAGB) at 6 bariatric centers in Australia, Europe, and Brazil, with ≤5 years of follow-up; the effect on patient covariates; and changes in co-morbidity.MethodsA 2-phase study design was used, involving both retrospective and prospective data. SAGB was implanted by way of the pars flaccida 1, 3, and 5 years previously. The retrospective phase entailed a review of the records. The prospective phase included a subset of eligible patients who agreed to undergo additional clinical assessments. The percentage of excess weight loss (%EWL), patient level predictors, change in co-morbidities, and complications were analyzed.ResultsA total of 481 patients in 3 mutually exclusive follow-up cohorts (1 yr, n = 200; 3 yr, n = 184; 5 yr, n = 97) participated in the present study. Of these 481 patients, 339 (1 yr, n = 139; 3 yr, n = 131; 5 yr, n = 69) underwent prospective evaluations. The mean %EWL was 43.5% ± 21.8%, 57.7% ± 25.9%, and 49.8% ± 27.6% and the mean change in body mass index was ?7.64, ?10.75, and ?9.52 in the 1-, 3-, and 5-year cohorts, respectively (P <.001). Gender and age did not predict the %EWL; however, a greater preoperative body mass index was inversely related to the %EWL. Longer postimplantation times were associated with greater improvement in co-morbidities and with greater frequencies of reoperation. Fewer than 15% of the patients in the 5-year cohort had undergone band removal and 10% required band revisions. No fatal or life-threatening complications occurred.ConclusionSAGB is safe and effective in inducing weight loss and improvement of co-morbidities in morbidly obese patients at international bariatric centers at 1, 3, and 5 years postoperatively. 相似文献
996.
Chung YL Lee MY Horng CF Jian JJ Cheng SH Tsai SY Hsieh CI Yen LK Lin CY 《Head & neck》2009,31(1):9-20
Background.
Environmental exposures to tobacco, alcohol, human papillomavirus (HPV) and/or Epstein‐Barr virus (EBV), all of which can perturb multiple cell cycle proteins or tumor suppressors, have been implicated in the pathogenesis of different subsets of head and neck cancers. The aim of this study was to investigate to which extent the virus infection by itself, and/or the altered cell cycle proteins, contributes to prognosis in locally advanced tonsillar squamous cell carcinomas (TSCCs) treated with concurrent chemoradiotherapy (CCRT) alone.Methods.
Serial tumor tissue arrays from archival samples were tested for the presence of HPV genome integration or EBV episome by means of DNA sequencing, real‐time polymerase chain reaction (PCR), and in situ hybridization. Alterations of cell cycle proteins (p53, pRb, and p21) were evaluated by immunohistochemical staining. The association of viral presence with altered cell cycle proteins was correlated to clinical outcomes.Results.
Of the 46 patients with the same T2N2bM0 stage IVA among consecutive patients with TSCC, 23 (50%) had integrated HPV DNA and only 1 (2%) had EBV episome. The HPV types detected were almost all HPV‐16. A reduced expression pattern of p53, pRb, and p21 was noted in HPV‐positive tumors, and the incremental number of alterations in the 3 proteins was significantly associated with HPV‐negative tumors. The presence or absence of HPV together with the number of altered expression of the 3 cell cycle markers resulted in further identification of 4 biologically and clinically distinct subgroups with different outcomes after CCRT.Conclusions.
Use of combined biomarkers of oncogenic HPV and tumor suppressors of p53, pRb, and p21 in advanced TSCC provides prognostic molecular classification superior to the TNM stage system and identifies low‐risk patients for organ preservation by CCRT alone and high‐risk patients who might benefit from planned tonsillectomy and neck dissection before or after CCRT. © 2008 Wiley Periodicals, Inc. Head Neck, 2009 相似文献997.
998.
999.
Yves d'Udekem MD PhD Michael M.H. Cheung MD MRCP Stella Setyapranata BMedSci Ajay J. Iyengar BmedSci Patricia Kelly BSCi Naomi Buckland BSCi B Eng Leeanne E. Grigg MBBS FRACP Robert G. Weintraub MBBS FRACP Alasdair Vance MD PhD Christian P. Brizard MD Dan J. Penny MD PhD 《The Annals of thoracic surgery》2009,88(6):1961-1969
1000.
Enhancement of the function of rat serotonin and norepinephrine neurons by sustained vagus nerve stimulation 下载免费PDF全文
Stella Manta Jianming Dong Guy Debonnel Pierre Blier 《Journal of psychiatry & neuroscience : JPN》2009,34(4):272-280