全文获取类型
收费全文 | 2801篇 |
免费 | 146篇 |
国内免费 | 31篇 |
专业分类
耳鼻咽喉 | 69篇 |
儿科学 | 88篇 |
妇产科学 | 72篇 |
基础医学 | 450篇 |
口腔科学 | 42篇 |
临床医学 | 228篇 |
内科学 | 671篇 |
皮肤病学 | 74篇 |
神经病学 | 186篇 |
特种医学 | 81篇 |
外科学 | 418篇 |
综合类 | 13篇 |
预防医学 | 137篇 |
眼科学 | 48篇 |
药学 | 139篇 |
中国医学 | 1篇 |
肿瘤学 | 261篇 |
出版年
2023年 | 33篇 |
2022年 | 44篇 |
2021年 | 90篇 |
2020年 | 50篇 |
2019年 | 58篇 |
2018年 | 87篇 |
2017年 | 63篇 |
2016年 | 71篇 |
2015年 | 90篇 |
2014年 | 105篇 |
2013年 | 138篇 |
2012年 | 192篇 |
2011年 | 209篇 |
2010年 | 125篇 |
2009年 | 97篇 |
2008年 | 170篇 |
2007年 | 169篇 |
2006年 | 169篇 |
2005年 | 189篇 |
2004年 | 179篇 |
2003年 | 143篇 |
2002年 | 127篇 |
2001年 | 33篇 |
2000年 | 35篇 |
1999年 | 24篇 |
1998年 | 29篇 |
1997年 | 22篇 |
1996年 | 26篇 |
1995年 | 15篇 |
1994年 | 13篇 |
1993年 | 9篇 |
1992年 | 23篇 |
1991年 | 13篇 |
1990年 | 11篇 |
1989年 | 22篇 |
1988年 | 11篇 |
1987年 | 10篇 |
1986年 | 10篇 |
1985年 | 12篇 |
1984年 | 3篇 |
1983年 | 8篇 |
1981年 | 4篇 |
1980年 | 5篇 |
1979年 | 5篇 |
1976年 | 8篇 |
1975年 | 3篇 |
1968年 | 3篇 |
1966年 | 2篇 |
1964年 | 2篇 |
1963年 | 2篇 |
排序方式: 共有2978条查询结果,搜索用时 46 毫秒
71.
Dioguardi Mario Alovisi Mario Troiano Giuseppe Caponio Carlo Vito Alberto Baldi Andrea Rocca Giovanni Tommaso Comba Allegra Lo Muzio Lorenzo Scotti Nicola 《Clinical oral investigations》2021,25(12):6597-6621
Clinical Oral Investigations - The survival rate of indirect partial adhesive restorations on vital versus endodontically treated teeth is still controversial. The hypothesis is that there may be a... 相似文献
72.
73.
74.
Antonio Aloi Adalberto Brunetti Giuseppe Perna Maria Lasalvia Vito Capozzi Raffaele Tommasi 《Biomedical optics express》2015,6(10):4000-4013
An ultrafast investigation is carried out on synthetic eumelanin suspended either in water or in DMSO-methanol. Upon photoexcitation by visible femtosecond pulses, the transient absorption (TA) dynamics of the suspensions are probed in a broad visible spectral range, showing clear nonlinearities. The latter arise from pump-probe interactions that induce the inverse Raman scattering (IRS) effect. We show how eumelanin TA dynamics are modified in proximity of the solvent Stokes and anti-Stokes scattering peaks, demonstrating that IRS affects the sign of TA but not the relaxation times. We compare the results obtained in both suspensions, unveiling the role of the surrounding environment. Eventually, the intrinsic response of synthetic eumelanin to ultrafast photoexcitation is evaluated.OCIS codes: (160.1435) Biomaterials, (320.7150) Ultrafast spectroscopy, (300.6240) Spectroscopy, coherent transient, (190.5890) Scattering, stimulated 相似文献
75.
Kuusk Teele Biancari Fausto Lane Brian Tobert Conrad Campbell Steven Rimon Uri D’Andrea Vito Mehik Aare Vaarala Markku H. 《BMC urology》2015,15(1):1-4
Epididymal anomalies and patent processus vaginalis are frequently found in boys with cryptorchidism or hydrocele. We conducted this study to evaluate the association between epididymal anomalies and testicular location or patent processus vaginalis in boys with undescended testis or hydrocele. Children undergoing surgery with undescended testis (group A, 136 boys and 162 testes) or communicating hydrocele (group B, 93 boys and 96 testes) were included. Testicular locations and epididymal anomalies were investigated prospectively. An anomalous epididymis was defined as anomalies of epididymal fusion that consisted of loss of continuity between the testis, the epididymis, and the long looping epididymis. The epididymis was considered normal when a normal, firm attachment between the testis, the caput, and the cauda epididymis was present. The mean ages of groups A and B were 24.6 ± 19.7 (range, 8–52 months) and 31.4 ± 20.6 months (range, 10–59 months). The incidence of epididymal anomalies was significantly higher in group A than that in group B (65.4 % vs. 13.5 %, P < 0.001). The incidence of epididymal anomalies in boys with undescended testis was significantly different according to testis location. Epididymal anomalies were observed in 100 %, 91.4 %, and 39.3 % of cases when the testis was located in the abdomen, inguinal canal, and distal to the external inguinal ring, respectively (P < 0.001). We conclude that epididymal anomalies were more frequent in boys with undescended testis than in boys with hydrocele, and that these anomalies were more frequent when undescended testis was at a higher level. These results suggest that testicular location is associated with epididymal anomalies rather than patent processus vaginalis. 相似文献
76.
Giorgio Gandaglia Nazareno Suardi Vito Cucchiara Marco Bianchi Shahrokh F. Shariat Morgan Roupret Andrea Salonia Francesco Montorsi Alberto Briganti 《Translational andrology and urology》2015,4(2):110-123
Context
Erectile dysfunction (ED) represents one of the most common long-term side effects in patients with clinically localized prostate cancer (PCa) undergoing nerve-sparing radical prostatectomy (RP).Objective
To analyze the role of penile rehabilitation in the recovery of erectile function (EF) after nerve-sparing RP.Evidence synthesis
Penile rehabilitation is defined as the use of any intervention or combination with the goal not only to achieve erections sufficient for satisfactory sexual intercourses, but also to return EF to preoperative levels. The concept of rehabilitation is based on the implementation of protocols aimed at improving oxygenation, preserving endothelial structure, and preventing smooth muscle structural alterations. Nowadays, the most commonly adopted approaches for penile rehabilitation after nerve-sparing RP are represented by the administration of phosphodiesterase type-5 inhibitors (PDE5-Is), intracorporeal injection therapy, vacuum erection devices (VED), and the combination of these therapies. Several basic science studies support the rational for the adoption of penile rehabilitation protocols. Particularly, rehabilitation, set as early as possible, seems to be better than leaving the erectile tissues unassisted. On the other hand, results from solid prospective randomized trials finally assessing the long-term beneficial effects of PDE5-Is, intracavernosal injections, or VED on EF recovery after surgery are still lacking.Conclusions
Although preclinical evidences support the rationale for penile rehabilitation after nerve-sparing RP, clinical studies reported conflicting results regarding its efficacy on long-term EF recovery. Nowadays, which is the optimal rehabilitation program still represents a matter of debate. 相似文献77.
78.
Hume GE Fowler EV Doecke J Simms LA Huang N Palmieri O Griffiths LR Florin TH Annese V Radford-Smith GL 《Inflammatory bowel diseases》2008,14(5):585-590
BACKGROUND: The first major Crohn's disease (CD) susceptibility gene, NOD2, implicates the innate intestinal immune system and other pattern recognition receptors in the pathogenesis of this chronic, debilitating disorder. These include the Toll-like receptors, specifically TLR4 and TLR5. A variant in the TLR4 gene (A299G) has demonstrated variable association with CD. We aimed to investigate the relationship between TLR4 A299G and TLR5 N392ST, and an Australian inflammatory bowel disease cohort, and to explore the strength of association between TLR4 A299G and CD using global meta-analysis. METHODS: Cases (CD = 619, ulcerative colitis = 300) and controls (n = 360) were genotyped for TLR4 A299G, TLR5 N392ST, and the 4 major NOD2 mutations. Data were interrogated for case-control analysis prior to and after stratification by NOD2 genotype. Genotype-phenotype relationships were also sought. Meta-analysis was conducted via RevMan. RESULTS: The TLR4 A299G variant allele showed a significant association with CD compared to controls (P = 0.04) and a novel NOD2 haplotype was identified which strengthened this (P = 0.003). Furthermore, we identified that TLR4 A299G was associated with CD limited to the colon (P = 0.02). In the presence of the novel NOD2 haplotype, TLR4 A299G was more strongly associated with colonic disease (P < 0.001) and nonstricturing disease (P = 0.009). A meta-analysis of 11 CD cohorts identified a 1.5-fold increase in risk for the variant TLR4 A299G allele (P < 0.00001). CONCLUSIONS: TLR 4 A299G appears to be a significant risk factor for CD, in particular colonic, nonstricturing disease. Furthermore, we identified a novel NOD2 haplotype that strengthens the relationship between TLR4 A299G and these phenotypes. 相似文献
79.
Petta S Cammà C Di Marco V Alessi N Barbaria F Cabibi D Caldarella R Ciminnisi S Licata A Massenti MF Mazzola A Tarantino G Marchesini G Craxì A 《Hepatology (Baltimore, Md.)》2008,48(1):28-37
Retinol-binding protein 4 (RBP4) is an adipocytokine associated with insulin resistance (IR). We tested serum levels of RBP4 to assess its link with steatosis in patients with genotype 1 chronic hepatitis C (CHC) or nonalcoholic fatty liver disease (NAFLD). Nondiabetic patients with CHC (n = 143) or NAFLD (n = 37) were evaluated by liver biopsy and anthropometric and metabolic measurements, including IR by the homeostasis model assessment. Biopsies were scored by Scheuer classification for CHC, and Kleiner for NAFLD. Steatosis was tested as a continuous variable and graded as absent-mild <30%, or moderate-severe > or =30%. Thirty nondiabetic, nonobese blood donors served as controls. RBP4 levels were measured by a human competitive enzyme-linked immunosorbent assay kit (AdipoGen). Mean values of RBP4 were similar in NAFLD and CHC (35.3 +/- 9.3 microg/L versus 36.8 +/- 17.6; P = 0.47, respectively), and both were significantly higher than in controls (28.9 +/- 12.1; P = 0.02 and P = 0.01, respectively). RBP4 was higher in CHC patients with steatosis than in NAFLD (42.1 +/- 19.7 versus 35.2 +/- 9.3; P = 0.04). By linear regression, RBP4 was independently linked to steatosis only (P = 0.008) in CHC, and to elevated body mass index (P = 0.01) and low grading (P = 0.04) in NAFLD. By linear regression, steatosis was independently linked to homeostasis model assessment score (P = 0.03) and high RBP4 (P = 0.003) in CHC. By logistic regression, RBP4 was the only variable independently associated with moderate-severe steatosis in CHC (odds ratio, 1.045; 95% confidence interval, 1.020 to 1.070; P = 0.0004), whereas waist circumference was associated with moderate-severe steatosis in NAFLD (odds ratio, 1.095; 95% confidence interval, 1.007 to 1.192; P = 0.03). CONCLUSION: In nondiabetic, nonobese patients with genotype 1 CHC, serum RBP4 levels might be the expression of a virus-linked pathway to steatosis, largely unrelated to IR. 相似文献
80.