收费全文 | 2547114篇 |
免费 | 207577篇 |
国内免费 | 4810篇 |
耳鼻咽喉 | 36240篇 |
儿科学 | 77373篇 |
妇产科学 | 66640篇 |
基础医学 | 357144篇 |
口腔科学 | 71452篇 |
临床医学 | 232543篇 |
内科学 | 503586篇 |
皮肤病学 | 50793篇 |
神经病学 | 217820篇 |
特种医学 | 101604篇 |
外国民族医学 | 900篇 |
外科学 | 386689篇 |
综合类 | 59105篇 |
现状与发展 | 3篇 |
一般理论 | 1238篇 |
预防医学 | 207258篇 |
眼科学 | 59105篇 |
药学 | 189307篇 |
5篇 | |
中国医学 | 4663篇 |
肿瘤学 | 136033篇 |
2018年 | 27566篇 |
2017年 | 21458篇 |
2016年 | 23490篇 |
2015年 | 26685篇 |
2014年 | 38272篇 |
2013年 | 58213篇 |
2012年 | 79367篇 |
2011年 | 83759篇 |
2010年 | 48957篇 |
2009年 | 46758篇 |
2008年 | 79702篇 |
2007年 | 84708篇 |
2006年 | 85115篇 |
2005年 | 83541篇 |
2004年 | 80386篇 |
2003年 | 77498篇 |
2002年 | 76255篇 |
2001年 | 114201篇 |
2000年 | 117929篇 |
1999年 | 100187篇 |
1998年 | 30043篇 |
1997年 | 27406篇 |
1996年 | 27170篇 |
1995年 | 26166篇 |
1994年 | 24580篇 |
1993年 | 22879篇 |
1992年 | 80445篇 |
1991年 | 77414篇 |
1990年 | 74493篇 |
1989年 | 71700篇 |
1988年 | 66757篇 |
1987年 | 65712篇 |
1986年 | 62226篇 |
1985年 | 59389篇 |
1984年 | 45450篇 |
1983年 | 38869篇 |
1982年 | 24336篇 |
1981年 | 21659篇 |
1980年 | 20284篇 |
1979年 | 42022篇 |
1978年 | 29800篇 |
1977年 | 25150篇 |
1976年 | 23531篇 |
1975年 | 24607篇 |
1974年 | 30252篇 |
1973年 | 28569篇 |
1972年 | 26669篇 |
1971年 | 24491篇 |
1970年 | 23081篇 |
1969年 | 21346篇 |
Areas covered: the principal pharmacogenetic and non-genetic differences in the pharmacology of tamoxifen and endoxifen are evaluated. To this end, references from PubMed, Embase or Web of Science, among others, were reviewed As non-genetic factors, important differences and similarities such age, or adherence to tamoxifen therapy are comprehensively illustrated. Additionally, since CYP2D6 genotypes are considered the main limitation of tamoxifen, many studies have investigated the association between the worsened clinical outcomes in patients with non-functional CYP2D6 genotypes. In this review, an overview of the research on this field is presented. Also, a summary describing the literature about individualizing tamoxifen therapy with endoxifen concentrations and its limitations is listed.
Expert opinion: z-endoxifen hydrochloride is only investigated in the metastatic setting, still more research is required before its place in therapeutics is known. Similarly, monitoring tamoxifen efficacy based on endoxifen concentrations might not be overall recommended due to the limited evidence available. 相似文献
Background
One approach to boost influenza vaccination coverage has been to expand immunization authority. In 2012, the province of Ontario gave community pharmacists the authority to administer the influenza vaccine.Objective
This study investigates the perspectives of Ontario pharmacy patrons, who had not recently received this vaccine from a pharmacist, regarding this pharmacist service.Methods
A survey was administered in six Ontario community pharmacies to pharmacy patrons who had not received an influenza vaccination from a pharmacist during the previous year. The instrument included questions about influenza vaccination, and knowledge of and attitudes toward vaccines and pharmacist-administered immunization.Results
A total of 541 pharmacy patrons completed the survey (53.9% response rate). About one-third (30.5%) of respondents were not aware that pharmacists could give the influenza vaccine, with younger individuals being less likely to be aware (OR 0.48, 95% CI 0.29–0.77, p?<?0.05) and less likely to receive the vaccine annually (OR 0.28, 95% CI 0.19–0.42, p?<?0.05). Leading reasons respondents gave as to why they did not receive their influenza vaccine from a pharmacist included not wanting or feeling they needed to be immunized (41.6%) and being used to receiving the vaccine from a physician (16.5%). Concerns about the experience and training of pharmacists and lack of privacy in a community pharmacy were uncommon.Conclusion
Reduced awareness of the availability of pharmacist-provided influenza vaccine is still common. Pharmacists have a significant opportunity to address lack of awareness and vaccine hesitancy issues. They can promote this service to increase influenza vaccination rates among pharmacy patrons who do not utilize this professional service. 相似文献Ressults show that opportunities for improving O&M include; operation of public toilets is a source of livelihood; operators are knowledgeable on occupational risks, and the community is involvedin sanitation activities. Barriers to effective O&M include; high operation costs, failure to break even and a lack of investments in occupational health Therefore, there is need to recognise the significance of public toilets as a viable alternative to open defecation in areas where ownership of private sanitation facilities is difficult. Failure to observe the health and safety of toilet operators may further compromise O&M. 相似文献