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31.
Kanwaljeet Garg Sumit Sinha Ashok Kumar Mahapatra Bhawani Shankar Sharma 《Child's nervous system》2014,30(5):919-923
Purpose
The purpose of the study was to analyze the surgical outcomes in children (≤18 years) with brachial plexus injury operated between April 2008 and March 2012 at our center.Methods
All children <18 years of age admitted to our center and surgically treated with a diagnosis of posttraumatic brachial plexus injury were included in the study. The demographic details of these patients were retrieved from the computerized database of our hospital. The results were analyzed in terms of the mode of injury, type of injury, surgical procedure performed, and motor recovery after the surgery (MRC Grading). Motor recovery with MRC >3/5 was termed as good outcome.Observations
A total of 33 patients were surgically treated. The mean age at presentation was 15.1 (range 4–18) years. Boys constituted 79 % (n?=?26) of our patient population. High-velocity injury was the commonest mode of injury. Panbrachial injury was the commonest seen in 82 % (n?=?27) of patients. Mean duration between injury and surgical intervention was 6 (range 2–13, SD?±?2.6) months. Majority of patients underwent neurotization procedure. Mean follow-up was 32 (range 6–51) months.Conclusions
High-velocity trauma is the most common mode on injury. Global palsy involving all the plexal elements was present in 82 % of the children. Neurotization was the most commonly performed surgical procedure. Good motor outcome (MRC grade ≥3/5) was seen in 62 % of patients. 相似文献32.
Kanwaljeet Garg Pankaj Kumar Singh Bhawani Shankar Sharma Poodipedi Sarat Chandra Ashish Suri Manmohanjit Singh Rajinder Kumar Shashank Sarad Kale Nalin Kumar Mishra Shailesh K Gaikwad Ashok Kumar Mahapatra 《Child's nervous system》2014,30(5):873-883
Purpose
Intracranial aneurysms in children are not as common as in adults and there are many differences in the etiology, demographic variables, aneurysm location, aneurysm morphological characteristics, clinical presentation, and outcome in pediatric and adult intracranial aneurysms.Methods
All children (≤18 years) suffering from intracranial aneurysm managed at our center from July 2001 through June 2013 were included in the study, and the details of these patients were retrieved from the computerized database of our hospital.Observations
A total of 62 pediatric patients were treated for 74 aneurysms during the study period and constituted 2.3 % of all intracranial aneurysms treated during the same period. The mean age at presentation was 13.5 years. Headache (82 %) was the commonest presenting feature; other symptoms included seizures (21 %), ictal loss of consciousness (27 %), and motor/cranial nerve deficits (22.6 %). Computed tomogram revealed subarachnoid hemorrhage in 58 % of patients. Eighty-two percent of aneurysms were in anterior circulation. Sixty-seven percent of aneurysms were complex aneurysms. Fifty-eight percent of patients underwent surgical intervention while 30 % underwent endovascular procedures. Twenty-one percent of the patients developed vasospasm. There was no postoperative mortality. Favorable outcome was seen in 72 % of the patients.Conclusions
Pediatric intracranial aneurysms are uncommon as compared to in adult patients. Seizures and cranial nerve involvement are seen more often as the presenting features in children. Posterior circulation aneurysms are more common in children, as are the internal carotid artery bifurcation aneurysms. There is high incidence of giant, posttraumatic, and mycotic aneurysms in children. 相似文献33.
Fufa D. Bari Satya Parida Tesfaalem Tekleghiorghis Aldo Dekker Abraham Sangula Richard Reeve Daniel T. Haydon David J. Paton Mana Mahapatra 《Vaccine》2014
Vaccine strain selection for emerging foot-and-mouth disease virus (FMDV) outbreaks in enzootic countries can be addressed through antigenic and genetic characterisation of recently circulating viruses. A total of 56 serotype A FMDVs isolated between 1998 and 2012, from Central, East and North African countries were characterised antigenically by virus neutralisation test using antisera to three existing and four candidate vaccine strains and, genetically by characterising the full capsid sequence data. A Bayesian analysis of the capsid sequence data revealed the viruses to be of either African or Asian topotypes with subdivision of the African topotype viruses into four genotypes (Genotypes I, II, IV and VII). The existing vaccine strains were found to be least cross-reactive (good matches observed for only 5.4–46.4% of the sampled viruses). Three bovine antisera, raised against A-EA-2007, A-EA-1981 and A-EA-1984 viruses, exhibited broad cross-neutralisation, towards more than 85% of the circulating viruses. Of the three vaccines, A-EA-2007 was the best showing more than 90% in-vitro cross-protection, as well as being the most recent amongst the vaccine strains used in this study. It therefore appears antigenically suitable as a vaccine strain to be used in the region in FMD control programmes. 相似文献
34.
35.
Nihar Ranjan Pani Lilakant Nath Akhilesh Vikram Singh Santosh Kumar Mahapatra 《Journal of Pharmaceutical Analysis》2012,2(6):492-498
Nateglinide has been widely used in the treatment of type-2 diabetics as an insulin secretogoga. A reliable, rapid, simple and sensitive reversed-phase high performance liquid chromatography (RP-HPLC) method was developed and validated for determination of nateglinide in rabbit plasma. The method was developed on Hypersil BDSC-18 column (250 mm×4.6 mm, 5 mm) using a mobile phase of 10 mM phosphate buffer (pH 2.5) and acetonitrile (35:65, v/v). The elute was monitored with the UV–vis detector at 210 nm with a flow rate of 1 mL/min. Calibration curve was linear over the concentration range of 25–2000 ng/mL. The retention times of nateglinide and internal standard (gliclazide) were 9.608 min and 11.821 min respectively. The developed RP-HPLC method can be successfully applied to the quantitative pharmacokinetic parameters determination of nateglinide in rabbit model. 相似文献
36.
Coracoid fractures are rare injuries which may be easily missed radiographically. This case report discusses a 14 year old child who sustained a coracoid fracture during a violent tackle whilst playing rugby. The fracture was clearly visible only on the axial view of the shoulder, and was subsequently confirmed by CT scan. This article includes a discussion detailing the anatomy and developmental features of the coracoid process of the scapula, its clinical significance, and radiological assessment of suspected coracoid injury. 相似文献
37.
38.
M. Abubakar M. Mahapatra M. Muniraju M. J. Arshed E. H. Khan A. C. Banyard Q. Ali S. Parida 《Transboundary and Emerging Diseases》2017,64(2):513-519
Peste des petits ruminants (PPR) is an economically important disease of small ruminants with a rapidly expanding geographical distribution. Peste des petits ruminants virus may manifest in a variety of ways with disease ranging from acute to subclinical. We investigated the exposure of large ruminants to PPRV in areas where the virus is endemic in the small ruminant population by assessing the serological status of groups of animals. This study focused on the Punjab province of Pakistan as an area where the virus is endemic and where mixed farming practices occur enabling close interactions between small and large ruminant populations. An overall PPR seropositivity was detected in 10.0% of cattle and 14.16% of buffaloes. Following an assessment of serological profiles in large ruminants within different age groups, a maximum seroprevalence was observed in cattle (17.5%) and buffaloes (22.5%) over 2 years of age indicating the potential utility of sampling large ruminant populations for PPR serosurveillance. The large ruminants sampled between one and two years of age had similar levels of seropositivity within populations with 11.2% and 16.2% of animals being seropositive, respectively. Current PPR vaccination strategies do not enable the differentiation between infected and vaccinated small ruminants, and as such, the serological surveillance of sheep and goats is of little value. When considering eradication programmes for PPRV, this factor is of great significance. However, where large and small ruminants are farmed together, serological surveillance of large ruminants may provide a snapshot of virus infection within populations where mild disease is present or where small ruminants are regularly vaccinated. 相似文献
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