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61.
H. Löwenstädt Sponholz F. Klopstock Tannenberg H. Laser Haagen Werthemann Robert Meyer 《Journal of cancer research and clinical oncology》1931,34(2-3):37-40
Ohne Zusammenfassung 相似文献
62.
Hugo Roth Demuth Lehnartz Kühnau und Sponholz 《Journal of cancer research and clinical oncology》1931,33(1):21-26
Ohne Zusammenfassung 相似文献
63.
64.
H. Brach Sponholz A. Fröhlich Haagen Lahm Krauspe Robert Meyer Cristofoletti Froboese Hadda 《Journal of cancer research and clinical oncology》1931,34(6):212-216
Ohne Zusammenfassung 相似文献
65.
Impact of plasma histones in human sepsis and their contribution to cellular injury and inflammation
Michael Liembo Ekaney Gordon Philipp Otto Maik Sossdorf Christoph Sponholz Michael Boehringer Wolfgang Loesche Daniel Rittirsch Arne Wilharm Oliver Kurzai Michael Bauer Ralf Alexander Claus 《Critical care (London, England)》2014,18(5)
Introduction
Circulating histones have been identified as mediators of damage in animal models of sepsis and in patients with trauma-associated lung injury. Despite existing controversies on actual histone concentrations, clinical implications and mechanism of action in various disease conditions, histone levels in human sepsis, association with disease progression and mediated effects on endothelial and immune cells remain unreported. This study aimed to determine histone levels and its clinical implication in septic patients and to elucidate histone-mediated effects ex-vivo.Methods
Histone levels, endogenous activated protein C (APC) levels and clinical data from two independent cohorts of septic patients were obtained. Histone levels were compared with various control groups including healthy individuals, intensive care unit (ICU) patients without sepsis, ICU patients with multiple organ failure and patients with minor or multiple trauma, all without infection. Endothelial and monocytic cells were stimulated with histones. Cellular integrity and sepsis prototypical cytokines were evaluated. The mechanism of action of histones via Toll-like receptor 4 (TLR4) was evaluated using a function blocking antibody. Histone degradation in plasma was studied by immunoblotting.Results
Histone H4 levels were significantly elevated in patients with sepsis (cohort I; n = 15 and cohort II; n = 19) versus ICU controls (n = 12), patients with multiple organ failure (n = 12) or minor trauma (n = 7), associated with need for renal replacement therapy and decrease in platelet count during disease progression, and remarkably were significantly associated with increased mortality rates in septic patients (ICU-, 28 day- and 90 day mortality rates). There was an inverse correlation between plasma histones and endogenous APC levels. Histone stimulation induced the release of sepsis prototypic cytokines and decreased cell integrity indicated by a significant increase of lactate dehydrogenase (LDH) and propidium iodide (PI) staining. Blocking of TLR4 decreased cellular cytotoxicity on endothelial cells. The calculated half-life of histones in spiked plasma was 4.6 minutes.Conclusions
Histone levels in septic patients are significantly increased and might mediate disease aggravation by cellular injury and inflammation via TLR4 signaling, which potentially results in multiple organ failure and fatal outcome. 相似文献66.
67.
With the aid of the measurements of tooth mobility the treatment success of grinding was evaluated in 208 upper incisors of 54 patients, and the results were set into correlation with different factors. The results show that decreased tooth mobility following grinding was observed both in healthy periodontium and in diseased periodontium. 相似文献
68.
Sponholz Riecke Werthemann Krauspe Böhmig Drügg H. Hruszek G. Kelemen Lothar Hofmann 《Journal of cancer research and clinical oncology》1939,49(4):153-157
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69.
70.