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41.
Osteonecrosis of the jaw (ONJ) is a serious side effect of bisphosphonate use in patients with osteoporosis, Paget's disease, hypercalcemia of malignancy, metastatic bone disease and multiple myeloma, although recently this complication has also been reported in patients under non‐bisphosphonate medication, such as denosumab and bevacizumab. The occurrence of ONJ is higher in oncology patients treated with high‐dose iv bisphosphonates than in osteoporosis patients treated with oral bisphosphonates. Although multiple hypotheses have been proposed, the exact pathogenic mechanism of ONJ still remains unclear. As treatment protocols based on randomized controlled trials (RCTs) do not exist, we critically reviewed the existing data concerning the management of bisphosphonate‐related osteonecrosis of the jaw, including the most recent data for the use of teriparatide and hyperbaric oxygen. 相似文献
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Jelinek J; Fairbairn LJ; Dexter TM; Rafferty JA; Stocking C; Ostertag W; Margison GP 《Blood》1996,87(5):1957-1961
A human O6-alkylguanine-DNA-alkyltransferase (ATase) cDNA-containing retrovirus was used to infect murine long-term primary bone marrow cultures. High levels of ATase expression were obtained, and colony- forming cells of the granulocyte-macrophage lineage from the cultures transduced with the human ATase retrovirus were three times more resistant to the alkylating agent, N-methyl-N-nitrosourea (MNU), than control cultures. Furthermore, expression of the human ATase protected long-term hematopoiesis, measured as the output of progenitor cells to the nonadherent fraction of the culture, against the cytotoxic effects of repeated exposures to MNU. These results clearly show that a human ATase cDNA-containing retrovirus can be used to infect long-term primary bone marrow cultures and that this attenuates their sensitivity to nitrosoureas. 相似文献
44.
Silvia Marino Andrea Di Cataldo Gaetano Magro Salvatore D'Amico Milena La Spina Vincenzo Di Benedetto Mariaclaudia Meli Carla Moscheo Giovanna Russo 《Clinical Case Reports》2015,3(3):179-182
We report a rare clinical presentation of childhood Hodgkin lymphoma with immune thrombocytopenia. Diagnostic biopsy of the abdominal mass was performed after administration of intravenous immunoglobulins, steroids, and platelet transfusion. Concomitant thrombocytopenia complicated the whole diagnosis work up and the initial management of neoplasia. 相似文献
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NCE Smith GP Findlay D Weyman H Freeth 《Annals of the Royal College of Surgeons of England》2013,95(2):101-106
Introduction
In 2006 the National Confidential Enquiry into Patient Outcome and Death undertook a large prospective study of trauma care, which revealed several findings pertaining to the management of head injuries in a sample of 493 patients.Methods
Case note data were collected for all trauma patients admitted to all hospitals accepting emergencies in England, Wales, Northern Ireland and the Channel Islands over a three-month period. Severely injured patients with an injury severity score (ISS) of ≥16 were included in the study. The case notes for these patients were peer reviewed by a multidisciplinary group of clinicians, who rated the overall level of care the patient received.Results
Of the 795 patients who met the inclusion criteria for the study, 493 were admitted with a head injury. Room for improvement in the level of care was found in a substantial number of patients (265/493). Good practice was found to be highest in high volume centres. The overall head injury management was found to be satisfactory in 84% of cases (319/381).Conclusions
This study has shown that care for trauma patients with head injury is frequently rated as less than good and suggests potential long-term remedies for the problem, including a reconfiguration of trauma services and better provision of neurocritical care facilities. 相似文献47.
Zeshan Ahmed Eileen H. Bigio Herbert Budka Dennis W. Dickson Isidro Ferrer Bernardino Ghetti Giorgio Giaccone Kimmo J. Hatanpaa Janice L. Holton Keith A. Josephs James Powers Salvatore Spina Hitoshi Takahashi Charles L. White III Tamas Revesz Gabor G. Kovacs 《Acta neuropathologica》2013,126(4):537-544
Recent studies have highlighted a group of 4-repeat (4R) tauopathies that are characterised neuropathologically by widespread, globular glial inclusions (GGIs). Tau immunohistochemistry reveals 4R immunoreactive globular oligodendroglial and astrocytic inclusions and the latter are predominantly negative for Gallyas silver staining. These cases are associated with a range of clinical presentations, which correlate with the severity and distribution of underlying tau pathology and neurodegeneration. Their heterogeneous clinicopathological features combined with their rarity and under-recognition have led to cases characterised by GGIs being described in the literature using various and redundant terminologies. In this report, a group of neuropathologists form a consensus on the terminology and classification of cases with GGIs. After studying microscopic images from previously reported cases with suspected GGIs (n = 22), this panel of neuropathologists with extensive experience in the diagnosis of neurodegenerative diseases and a documented record of previous experience with at least one case with GGIs, agreed that (1) GGIs were present in all the cases reviewed; (2) the morphology of globular astrocytic inclusions was different to tufted astrocytes and finally that (3) the cases represented a number of different neuropathological subtypes. They also agreed that the different morphological subtypes are likely to be part of a spectrum of a distinct disease entity, for which they recommend that the overarching term globular glial tauopathy (GGT) should be used. Type I cases typically present with frontotemporal dementia, which correlates with the fronto-temporal distribution of pathology. Type II cases are characterised by pyramidal features reflecting motor cortex involvement and corticospinal tract degeneration. Type III cases can present with a combination of frontotemporal dementia and motor neuron disease with fronto-temporal cortex, motor cortex and corticospinal tract being severely affected. Extrapyramidal features can be present in Type II and III cases and significant degeneration of the white matter is a feature of all GGT subtypes. Improved detection and classification will be necessary for the establishment of neuropathological and clinical diagnostic research criteria in the future. 相似文献
48.
Spina Emanuele Doneddu Pietro Emiliano Liberatore Giuseppe Cocito Dario Fazio Raffaella Briani Chiara Filosto Massimiliano Benedetti Luana Antonini Giovanni Cosentino Giuseppe Jann Stefano Mazzeo Anna Cortese Andrea Marfia Girolama Alessandra Clerici Angelo Maurizio Siciliano Gabriele Carpo Marinella Luigetti Marco Lauria Giuseppe Rosso Tiziana Cavaletti Guido Peci Erdita Tronci Stefano Ruiz Marta Piccinelli Stefano Cotti Schenone Angelo Leonardi Luca Gentile Luca Piccolo Laura Mataluni Giorgia Santoro Lucio Nobile-Orazio Eduardo Manganelli Fiore 《Journal of neurology》2022,269(2):907-912
Journal of Neurology - Compression of the median nerve at the carpal tunnel can give demyelinating features and result in distal motor latency (DML) prolongation fulfilling the EFNS/PNS... 相似文献
49.
50.
Janet Sultana Domenico Italiano Edoardo Spina Claudio Cricelli Francesco Lapi Serena Pecchioli Giovanni Gambassi Gianluca Trifirò 《European journal of clinical pharmacology》2014,70(4):469-478