Correction: Electrochemical investigation and amperometry determination iodate based on ionic liquid/polyoxotungstate/P-doped electrochemically reduced graphene oxide multi-component nanocomposite modified glassy carbon electrode

Correction for ‘Electrochemical investigation and amperometry determination iodate based on ionic liquid/polyoxotungstate/P-doped electrochemically reduced graphene oxide multi-component nanocomposite modified glassy carbon electrode’ by Minoo Sharifi et al., RSC Adv., 2021, 11, 8993–9007, DOI: 10.1039/D1RA00845E.

The authors regret that eqn (3) and (4) were shown incorrectly in the original article.The corrected equations are shown below.3H₄SiW₄^VW₇^VINi(H₂O)O₃₉⁶⁻ + IO₃⁻ → 3H₂SiW₂^VW₉^VINi(H₂O)O₃₉⁶⁻ + I⁻ + 3H₂O (3)3H₆SiW₆^VW₅^VINi(H₂O)O₃₉⁶⁻ + IO₃⁻ → 3H₄SiW₄^VW₇^VINi(H₂O)O₃₉⁶⁻ + I⁻ + 3H₂O (4)The Royal Society of Chemistry apologises for these errors and any consequent inconvenience to authors and readers.     

Contribution of Fc fragment of monoclonal antibodies to tetanus toxin neutralization

Neurotoxicity Research - Monoclonal antibodies (MAbs) against neurotoxin of Clostridium tetani are considered as a novel source of immunoglobulins for passive immunotherapy of tetanus. Toxin...     

Improved dynamic connection detection power in estimated dynamic functional connectivity considering multivariate dependencies between brain regions

To estimate dynamic functional connectivity (dFC), the conventional method of sliding window correlation (SWC) suffers from poor performance of dynamic connection detection. This stems from the equal weighting of observations, suboptimal time scale, nonsparse output, and the fact that it is bivariate. To overcome these limitations, we exploited the kernel‐reweighted logistic regression (KELLER) algorithm, a method that is common in genetic studies, to estimate dFC in resting state functional magnetic resonance imaging (rs‐fMRI) data. KELLER can estimate dFC through estimating both spatial and temporal patterns of functional connectivity between brain regions. This paper compares the performance of the proposed KELLER method with current methods (SWC and tapered‐SWC (T‐SWC) with different window lengths) based on both simulated and real rs‐fMRI data. Estimated dFC networks were assessed for detecting dynamically connected brain region pairs with hypothesis testing. Simulation results revealed that KELLER can detect dynamic connections with a statistical power of 87.35% compared with 70.17% and 58.54% associated with T‐SWC (p‐value = .001) and SWC (p‐value <.001), respectively. Results of these different methods applied on real rs‐fMRI data were investigated for two aspects: calculating the similarity between identified mean dynamic pattern and identifying dynamic pattern in default mode network (DMN). In 68% of subjects, the results of T‐SWC with window length of 100 s, among different window lengths, demonstrated the highest similarity to those of KELLER. With regards to DMN, KELLER estimated previously reported dynamic connection pairs between dorsal and ventral DMN while SWC‐based method was unable to detect these dynamic connections.     

Concanavalin A-conjugated gold nanoparticle/silica quantum dot (AuNPs/SiQDs-Con A)-based platform as a fluorescent nanoprobe for the bioimaging of glycan-positive cancer cells

The glycan receptor is a glycosylphosphatidylinositol glycoprotein that is overexpressed on the surface of various cancer cells and has been utilized for wide applications. In the present work, the surface of citrate-capped gold nanoparticles (cit-AuNPs) was modified with mercaptopropionic acid (MPA) molecules to provide carboxylic groups for secondary functionalization with amine anchored-silica quantum dots (Si-NH₂ QDs) to produce cit-AuNPs-MPA/Si-NH₂ QDs fluorescent nanoparticles. Concanavalin A (Con A) molecules were attached through thiol–AuNP bonds to produce the final cit-AuNPs/MPA/Si-NH₂ QDs/Con A smart nanoparticles. The synthesized novel cit-AuNPs/MPA/Si-NH₂ QDs/Con A nanoparticles were utilized for the bioimaging of glycan-overexpressed breast cancer cells. Fluorescence microscopy and flow cytometry results revealed that the cit-AuNPs/MPA/Si-NH₂ QDs/Con A NPs can be efficiently taken up by cancer cells, with differentiating ability between overexpressed cancer cells and low-expressed normal cells. The cellular viability of the cit-AuNPs/MPA/Si-NH₂ QDs/Con A NPs was tested by the MTT test, proving their biocompatible nature at the 200 μg mL⁻¹ level. In conclusion, the fabricated cit-AuNPs/MPA/Si-NH₂ QDs/Con A NPs could be utilized for the bioimaging of MCF-7 cancer cells even in the clinical setting after proper in vivo validation.

The glycan receptor is a glycosylphosphatidylinositol glycoprotein that is overexpressed on the surface of various cancer cells and has been utilized for wide applications.     

Continuing Medical Education Program in Echocardiography

Article Title: Parachute Mitral Valve in Adults – A Systematic Overview (Echocardiography 2010;27:580)     

Antidiabetic effect of Phlomis anisodonta: effects on hepatic cells lipid peroxidation and antioxidant enzymes in experimental diabetes.

The present study investigated the effects of aerial parts of Phlomis anisodonta methanolic extract (PAE) on streptozotocin (STZ)-induced diabetic rats by measuring fasting blood glucose, serum insulin, change in body weight, ferric reducing antioxidant power (FRAP), lipid peroxidation (LPO), and liver antioxidant enzymes including superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx). Male Wistar rats were randomly divided into six groups of six animals. Treatment of diabetic rats with oral administration of PAE at doses of 100, 200 and 400 mg kg(-1) for 10 days resulted in a significant reduction in fasting blood glucose, and an increase in serum insulin levels in comparison with diabetic control group. PAE also protected rats from STZ-induced loss in body weight. Hepatic FRAP increased and LPO in diabetic rats decreased after treatment by PAE at doses of 200 and 400 mg kg(-1). PAE-treated diabetic rats at three doses indicated a significant increase in hepatic SOD, CAT, and GPx activities. These results suggest that PAE is beneficial in the control of diabetes by reduction of blood glucose and increasing insulin levels and combating oxidative stress by activation of hepatic antioxidant enzymes.