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101.
Ellis RD Sagara I Durbin A Dicko A Shaffer D Miller L Assadou MH Kone M Kamate B Guindo O Fay MP Diallo DA Doumbo OK Emanuel EJ Millum J 《The American journal of tropical medicine and hygiene》2010,83(4):868-872
Initial responses to questionnaires used to assess participants' understanding of informed consent for malaria vaccine trials conducted in the United States and Mali were tallied. Total scores were analyzed by age, sex, literacy (if known), and location. Ninety-two percent (92%) of answers by United States participants and 85% of answers by Malian participants were correct. Questions more likely to be answered incorrectly in Mali related to risk, and to the type of vaccine. For adult participants, independent predictors of higher scores were younger age and female sex in the United States, and male sex in Mali. Scores in the United States were higher than in Mali (P = 0.005). Despite this difference participants at both sites were well informed overall. Although interpretation must be qualified because questionnaires were not intended as research tools and were not standardized among sites, these results do not support concerns about systematic low understanding among research participants in developing versus developed countries. 相似文献
102.
Sarro YS Tounkara A Tangara E Guindo O White HL Chamot E Kristensen S 《African health sciences》2010,10(2):138-143
Background
Developing world are always looking for monitoring tools during reagent shortage and equipments troubles which are very frequent. The aim of this study was to evaluate Serum Protein Electrophoresis (SPE) as a marker for assessing HIV treatment response.Methods
A cross-sectional study was conducted with 220 participants in four distinct groups: Symptomatic HIV positive patients [specifically those on antiretroviral treatment (ART) versus those not on ART] asymptomatic HIV positive patients, and healthy blood donors. Five serum protein fractions (Albumin, Alpha-1, Alpha-2, Beta, and Gamma) were compared between these groups after measuring the density of the fractions.Results
Concentration of gamma globulin was lowest among healthy blood donors, intermediate and comparable among asymptomatic HIV positive and symptomatic HIV positive on ART and highest among untreated symptomatic HIV positive. Concentration of gamma globulin was inversely correlated with the disease stage (p < 0.001).Conclusion
In this study, conducted in a setting where the burden of infectious diseases is high, the density of gamma globulin and albumin fractions were significantly associated with HIV status, and among HIV positive patients, with stage of HIV disease and ART. These results suggest that the feasibility of using SPE for monitoring the response of ART in low resource settings should be further explored. 相似文献103.
104.
Thera MA Doumbo OK Coulibaly D Laurens MB Ouattara A Kone AK Guindo AB Traore K Traore I Kouriba B Diallo DA Diarra I Daou M Dolo A Tolo Y Sissoko MS Niangaly A Sissoko M Takala-Harrison S Lyke KE Wu Y Blackwelder WC Godeaux O Vekemans J Dubois MC Ballou WR Cohen J Thompson D Dube T Soisson L Diggs CL House B Lanar DE Dutta S Heppner DG Plowe CV 《The New England journal of medicine》2011,365(11):1004-1013