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51.
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Ednei Luiz Antonio Andrey Jorge Serra Alexandra Alberta dos Santos Stella Sousa Vieira Jairo Montemor Augusto Silva Amanda Yoshizaki Renato Rodrigues Sofia Paulo José Ferreira Tucci 《Brazilian Journal Of Cardiovascular Surgery》2015,30(1):70-76
Objective
An unclear issue is whether gender may influence at cardiac remodeling after myocardial infarction (MI). We evaluated left ventricle remodeling in female and male rats post-MI.Methods
Rats were submitted to anterior descending coronary occlusion. Echocardiographic evaluations were performed on the first and sixth week post-occlusion to determine myocardial infarction size and left ventricle systolic function (FAC, fractional area change). Pulsed Doppler was applied to analyze left ventricle diastolic function using the following parameters: E wave, A wave, E/A ratio. Two-way ANOVA was applied for comparisons, complemented by the Bonferroni test. A P≤=0.05 was considered significant.Results
There were no significant differences between genders for morphometric parameters on first (MI [Female (FE): 44.0±5.0 vs. Male (MA): 42.0±3.0%]; diastolic [FE: 0.04±0.003 vs. MA: 0.037±0.005, mm/g] and systolic [FE: 0.03±0.0004 vs. MA: 0.028±0.005, mm/g] diameters of left ventricle) and sixth (MI [FE: 44.0±5.0 vs. MA: 42.0±3.0, %]; diastolic [FE: 0.043±0.01 vs. MA: 0.034±0.005, mm/g] and systolic [FE: 0.035±0.01 vs. MA: 0.027±0.005, mm/g] of LV) week. Similar findings were reported for left ventricle functional parameters on first (FAC [FE: 34.0±6.0 vs. MA: 32.0±4.0, %]; wave E [FE: 70.0±18.0 vs. MA: 73.0±14.0, cm/s]; wave A [FE: 20.0±12.0 vs. MA: 28.0±13.0, cm/s]; E/A [FE: 4.9±3.4 vs. MA: 3.3±1.8]) and sixth (FAC [FE: 29.0±7.0 vs. MA: 31.0±7.0, %]; wave E [FE: 85.0±18.0 vs. MA: 87.0±20.0, cm/s]; wave A [FE: 20.0±11.0 vs. MA: 28.0±17.0, cm/s]; E/A [FE: 6.2±4.0 vs. MA: 4.6±3.4]) week.Conclusion
Gender does not influence left ventricle remodeling post-MI in rats. 相似文献53.
RotaFlow and CentriMag Extracorporeal Membrane Oxygenation Support Systems as Treatment Strategies for Refractory Cardiogenic Shock 下载免费PDF全文
54.
Alessandro Martorana Francesco Di Lorenzo Lorena Belli Giuseppe Sancesario Sofia Toniolo Fabrizio Sallustio Giulia Maria Sancesario Giacomo Koch 《CNS Neuroscience & Therapeutics》2015,21(12):921-925
Impaired amyloid beta (Aβ) metabolism is currently considered central to understand the pathophysiology of Alzheimer's disease (AD). Measurements of cerebrospinal fluid Aβ levels remain the most useful marker for diagnostic purposes and to individuate people at risk for AD. Despite recent advances criticized the direct role in neurodegeneration of cortical neurons, Aβ is considered responsible for synaptopathy and impairment of neurotransmission and therefore remains the major trigger of AD and future pharmacological treatment remain Aβ oriented. However, experimental and clinical findings showed that Aβ peptides could have a wider range of action responsible for cell dysfunction and for appearance of clinico‐pathological entities different from AD. Such findings may induce misunderstanding of the real role played by Aβ in AD and therefore strengthen criticism on its centrality and need for CSF measurements. Aim of this review is to discuss the role of CSF Aβ levels in light of experimental, clinical pathologic, and electrophysiological results in AD and other pathological entities to put in a correct frame the value of Aβ changes. 相似文献
55.
Effect of postural angle on back muscle activities in aging female workers
performing computer tasks
Nabilla Sofia Mohd Kamil Siti Zawiah Md Dawal 《Journal of Physical Therapy Science》2015,27(6):1967-1970
[Purpose] This study investigated the effects of postural angle on back muscle activity
during a computer task in aging women. [Subjects] Seventeen women ≥50 years old
participated. [Methods] The participants were instructed to perform computer-related tasks
for 20 minutes on a workstation that simulated typical office working conditions. Back
posture was measured from the measured trunk and pelvic angles. Electromyography
activities were recorded simultaneously from the cervical erector spinae, longissimus, and
multifidus muscles. [Results] The lowest mean percentages of maximum voluntary contraction
for the cervical erector spinae and longissimus muscles were obtained when the upper trunk
and pelvic angles were between 0° to −5° from the sagittal plane. The back muscle
activities increased as the upper trunk and pelvic angles exceeded 0°. Statistical
analysis showed significant correlations between upper trunk angle and cervical erector
spinae and longissimus muscle activities. Similarly, pelvic angle was significantly
correlated with cervical erector spinae and multifidus muscle activities. [Conclusion] A
neutral back posture minimizes muscle activities in aging women performing computer
tasks.Key words: Postural angle, Muscle activity, Aging 相似文献
56.
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59.
Dipeptidyl peptidase-4 expression in pancreatic tissue from patients with congenital hyperinsulinism
Sofia A Rahman Senthil Senniappan Maha Sherif Sophia Tahir Khalid Hussain 《International journal of clinical and experimental pathology》2015,8(7):8199-8208
Congenital hyperinsulinism (CHI) is caused by unregulated insulin release and leads to hyperinsulinaemic-hypoglycaemia (HH). Glucagon like peptide-1 (GLP-1), glucose-dependent insulinotropic peptide (GIP), peptide YY (PYY) and the enzyme; dipeptidyl peptidase-4 (DPP-4) all regulate appetite and glucose homeostasis. These proteins have been identified as possible contributors to HH but the mechanism remains poorly understood. We aimed to look at the expression pattern of pancreatic DPP-4 in children with focal and diffuse CHI (FCHI and DCHI, respectively). Using immunohistochemistry; we determined DPP-4 expression patterns in the pancreas of CHI patients. DPP-4 was found to be expressed in the pancreatic β, α and δ-cells in and around the focal area. However, it was predominantly co-localised with β-cells in the paediatric tissue samples. Additionally, proliferating β-cells expressed DPP-4 in DCHI, which was absent in the FCHI pancreas. Insulin was found to be present in the exocrine acini and duct cells of the DCHI pancreas suggestive of exocrine to endocrine transdifferentiation. Furthermore, 6 medically-unresponsive DCHI pancreatic samples showed an up-regulation of total pancreatic DPP-4 expression. In conclusion; the expression studies have shown DPP-4 to be altered in HH, however, further work is required to understand the underlying role for this enzyme. 相似文献
60.
Salmonella thyroid abscess in human immunodeficiency virus‐positive man: A diagnostic pitfall in fine‐needle aspiration biopsy of thyroid lesions 下载免费PDF全文