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501.
Mirella Guarnizo-Poma Socorro Paico-Palacios Betzi Pantoja-Torres Herbert Lazaro-Alcantara Diego Urrunaga-Pastor Vicente A. Benites-Zapata 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(4):531-535
Aims
To determine the association between the thyroid hormones(FT3, FT4 and TSH) and the lipid profile markers(HDL-c, LDL-c and triglycerides) values in middle-aged women with no metabolic disorders and recurrent chronic symptomatology.Materials and Methods
We carried out an analytical cross-sectional study in euthyroid women with recurrent chronic symptoms of at least six months with no apparent diagnosis who attended the endocrinological gynaecology outpatient service of a private clinic in Lima-Peru during 2012–2014. Participants who met the eligibility criteria were evaluated according to their thyroid hormones(FT3, FT4 and TSH) and lipid profile markers(HDL-c, LDL-c and triglycerides) values. We elaborated univariate/multivariate linear regression models to evaluate the association between the thyroid markers and the lipid profile levels. The reported association measure was the beta coefficient(β) with its respective p-value.Results
We analyzed 211 participants, the average age was 44.9?±?14.0(SD) years, the FT3 and FT4 mean levels were 3.2?±?0.4?pg/mL and 1.2?±?0.2?ng/dL respectively, while the TSH median was 2.8(IQR:1.9–4.0) μU/mL. The mean or median levels of LDL-c, HDL-c and triglycerides were of 137.5?±?37.9?mg/dL, 54.0?±?15.0?mg/dL and 118.5(IQR:79.5–169.5) mg/dL respectively. In the multivariate linear regression model between the FT3 and LDL-c levels, we found that for each increase in a FT3 unit, the LDL-c values decreased on average 30.85?mg/dL(p?<?0.01). We found no statistically significant associations in the other multivariate models of linear regression, among the other thyroid hormones and lipid markers.Conclusion
We found an inverse association between the FT3 and LDL-c values in women with chronic gynaecological symptoms. 相似文献502.
López-Caneda E Cadaveira F Crego A Gómez-Suárez A Corral M Parada M Caamaño-Isorna F Rodríguez Holguín S 《Addiction (Abingdon, England)》2012,107(10):1796-1808
Aims The objective of this study was to examine brain activity, with particular attention to prefrontal function, during response execution and inhibition in youths who have engaged in binge drinking (BD) for at least 2 years. Design Event‐related potentials (ERPs) were recorded twice within 3 years, during performance of a Go/NoGo task. Setting The study was part of a longitudinal study of the neurocognitive effects of BD. Participants A total of 48 undergraduate students, 25 controls (14 females) and 23 binge drinkers (10 females), with no personal or family history of alcoholism or psychopathological disorders. Measurements The Go‐P3 and NoGo‐P3 components of the ERPs were examined by principal component analysis and exact low‐resolution tomography analysis (eLORETA). Findings Binge drinkers showed larger Go‐P3 amplitudes than controls in the first and second evaluations (P = 0.019). They also showed larger NoGo‐P3 amplitude in the second evaluation (P = 0.002). eLORETA analyses in the second evaluation revealed significantly greater activation of the right inferior frontal cortex (rIFC) in binge drinkers than in controls during successful inhibition (P < 0.05). Conclusions Young binge drinkers appear to show abnormal brain activity as measured by event‐related potentials during response execution and inhibition which may represent a neural antecedent of difficulties in impulse control. 相似文献
503.
Alejandro Martín García-Sancho Socorro M. Rodríguez-Pinilla Eva Domingo-Domenech Fina Climent Joaquín Sánchez-Garcia Javier López Jiménez Mónica García-Cosío Piqueras Josep Castellvi Ana Julia González Sonia González de Villambrosia José Gómez Codina Belén Navarro Guillermo Rodríguez Juan José Borrero Máximo Fraga Andrea Naves Lourdes Baeza Raúl Córdoba 《British journal of haematology》2023,203(2):182-193
Nodal peripheral T-cell lymphoma (PTCL) with a T follicular helper phenotype (PTCL-TFH) is a new type of PTCL. We aimed to define its clinical characteristics and prognosis compared to PTCL not otherwise specified (PTCL-NOS) and angioimmunoblastic T-cell lymphoma (AITL). This retrospective observational study included 175 patients diagnosed with PTCL between 2008 and 2013 in 13 Spanish sites. Patient diagnosis was centrally reviewed, and patients were reclassified according to the World Health Organization (WHO) 2016 criteria: 21 patients as PTCL-NOS, 55 as AITL and 23 as PTCL-TFH. Median follow-up was 56.07 months (95% CI 38.7–73.4). Progression-free survival (PFS) and overall survival (OS) were significantly higher in patients with PTCL-TFH than in those with PTCL-NOS and AITL (PFS, 24.6 months vs. 4.6 and 7.8 months, respectively, p = 0.002; OS, 52.6 months vs. 10.0 and 19.3 months, respectively, p < 0.001). Histological diagnosis maintained an independent influence on both PFS (hazard ratio [HR] 4.1 vs. PTCL-NOS, p = 0.008; HR 2.6 vs. AITL, p = 0.047) and OS (HR 5.7 vs. PTCL-NOS, p = 0.004; HR 2.6 vs. AITL, p = 0.096), regardless of the International Prognostic Index. These results suggest that PTCL-TFH could have more favourable features and prognosis than the other PTCL subtypes, although larger series are needed to corroborate these findings. 相似文献