全文获取类型
收费全文 | 697篇 |
免费 | 50篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 35篇 |
妇产科学 | 8篇 |
基础医学 | 91篇 |
口腔科学 | 32篇 |
临床医学 | 28篇 |
内科学 | 173篇 |
皮肤病学 | 35篇 |
神经病学 | 34篇 |
特种医学 | 11篇 |
外科学 | 115篇 |
综合类 | 5篇 |
预防医学 | 14篇 |
眼科学 | 2篇 |
药学 | 44篇 |
中国医学 | 1篇 |
肿瘤学 | 118篇 |
出版年
2023年 | 5篇 |
2022年 | 5篇 |
2021年 | 9篇 |
2020年 | 3篇 |
2019年 | 8篇 |
2018年 | 14篇 |
2017年 | 11篇 |
2016年 | 22篇 |
2015年 | 22篇 |
2014年 | 32篇 |
2013年 | 20篇 |
2012年 | 39篇 |
2011年 | 38篇 |
2010年 | 27篇 |
2009年 | 22篇 |
2008年 | 39篇 |
2007年 | 45篇 |
2006年 | 39篇 |
2005年 | 29篇 |
2004年 | 32篇 |
2003年 | 32篇 |
2002年 | 26篇 |
2001年 | 27篇 |
2000年 | 36篇 |
1999年 | 19篇 |
1998年 | 13篇 |
1997年 | 8篇 |
1996年 | 7篇 |
1994年 | 5篇 |
1993年 | 2篇 |
1992年 | 7篇 |
1991年 | 14篇 |
1990年 | 9篇 |
1989年 | 7篇 |
1988年 | 9篇 |
1987年 | 9篇 |
1986年 | 6篇 |
1985年 | 4篇 |
1984年 | 3篇 |
1983年 | 6篇 |
1980年 | 3篇 |
1978年 | 5篇 |
1977年 | 6篇 |
1971年 | 2篇 |
1970年 | 2篇 |
1969年 | 3篇 |
1968年 | 1篇 |
1967年 | 5篇 |
1966年 | 2篇 |
1963年 | 1篇 |
排序方式: 共有747条查询结果,搜索用时 15 毫秒
691.
T Matsushita J Takamatsu K Kagami I Takahashi I Sugiura M Hamaguchi T Kamiya H Saito 《American journal of hematology》1992,39(2):137-141
A 2-year-old Japanese girl with easy bruising and arthropathy was demonstrated to have severe hemophilia A (Factor VIII activity: less than 0.01 U/ml). She had normal 46XX karyotype. Her brother also had hemophilia A, and her mother and grandmother seem to be hemophiliac carriers. Additionally, activated partial thromboplastin time (APTT) of the patient was disproportionately prolonged and there were reduced levels of coagulation factor XII in the patients and members of the maternal trait which are compatible with heterozygous factor XII deficiency. Her father had both normal factor VIII and factor XII levels. Southern blotting analysis of genomic DNA from the propositus and family members with factor VIII and factor XII DNA probes revealed no gross alterations. This patient represents a female hemophilia A combined with heterozygous factor XII deficiency. Nonrandom inactivation of a normal X-chromosome (extreme lyonization) may be the basis for the expression of hemophilia A in this female patient. 相似文献
692.
693.
694.
M Matsubara J Imanishi H Yasuno K Kagami Y Ozaki C B Pak T Kishida 《The Journal of dermatology》1980,7(3):203-206
In order to examine the sensitivity of Herpes simplex virus (HSV) types 1 and 2 (nine strains were used) to human leukocyte interferon (HL-IF), human embryonic fibroblast (HEF) cultures were treated with 1 times 104 IU of HL-IF 24 hrs before each HSV was inoculated. Forty-eight and seventy-two hours after incubation at 37°C in a 5% CO2 atmosphere, cytopathogenic effect (CPE) or giant cell formation by HSV was observed. The TCID50 in control cultures was compared with that in IF-treated cultures. Although HL-IF could protect cell culture against HSV infection, no differences in sensitivity between the two types of HSV or among the nine strains of HSV to HL-IF were recognized. 相似文献
695.
T Kagami 《Nihon rinsho. Japanese journal of clinical medicine》1972,30(6):1368-1369
696.
697.
T Hotta S Goto K Tsushita Y Kagami H Ohashi A Ichikawa M Ichihara N Takagi T Murate H Yamao 《Leukemia》1991,5(11):962-966
Cytogenetic and bone marrow culture studies were performed sequentially in 13 patients with myelodysplastic syndromes (MDS) who responded to low dose cytosine arabinoside (Ara-C) treatment (complete in nine and partial in four patients). Of nine patients with initial clonal karyotypic abnormalities, six recovered a normal karyotype after attaining a response to treatment, but the other three patients retained partial or total karyotypic abnormalities. A new clonal karyotypic abnormality appeared after treatment in one patient. Eight patients showed normal colony growth of both granulocyte-macrophage colony-forming units and erythroid burst-forming units after treatment, but five were still defective. There was a clear difference in the duration of response to treatment between these two groups. Consolidation treatment was not effective in patients with persistent karyotypic abnormalities or defective colony formation. Although the number of patients studied is small, these results suggest that hemopoiesis in patients with MDS following a response to treatment with low dose Ara-C is heterogeneous. Consolidation chemotherapy is recommended to ensure and prolong the response in patients showing normalization of both cytogenetic and bone marrow culture results. 相似文献
698.
699.
T Sakaguchi S Sakaguchi I Nakamura M Kagami 《Sangyō igaku. Japanese journal of industrial health》1984,26(3):224-229
The effects of beryllium on cultured cells were investigated. Three cell-lines (HeLa-S3, Vero, HEL-R66) were used in these experiments and they were cultured in Eagle's MEM plus 5 or 10% FBS (Fetal Bovine Serum) containing beryllium in various concentrations. HeLa cells or Vero cells were able to grow in the medium with 10 micrograms Be/ml (1.1 mM). On the other hand, the growth of HEL cells were strongly inhibited, even when cultured in the medium with 1 microgram Be/ml (1.1 X 10(-1) mM) and the number of living cells showed markedly low level as compared to that of the control samples cultured in the medium without beryllium. The cytotoxic effects of beryllium on these cells, which were cultured for three days in the medium with beryllium, were observed. None of cytotoxic effects were found on HeLa cells cultured with 0.5 micrograms/ml (5.5 X 10(-2) mM) and on Vero cells cultured with 0.05 micrograms Be/ml (5.5 X 10(-3) mM), while HEL cells received cytotoxic effects even when cultured in the medium containing 0.05 micrograms Be/ml (5.5 X 10(-3) mM), and these effects on the cells appeared strong when cultured in the medium without FBS. It was revealed from these experiments that HEL cells are very sensitive in terms of toxic effects of beryllium. Therefore, there cells can be used for the toxicological study on low level concentrations of the metal. 相似文献
700.