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51.
52.
Nozawa H Tsuchiya M Kobayashi T Morita H Kobayashi I Sakaguchi M Mizutani T Tajima A Kishida Y Yakumaru K Kagami H Sekikawa T 《International journal of clinical practice》2003,57(4):329-331
Small intestinal metastasis from renal cell carcinoma (RCC) has only rarely been described. We report two patients who developed small bowel metastases from RCC showing different clinicopathological characteristics. Both patients underwent hemilateral nephrectomy for RCC and developed lung metastases metachronously or simultaneously. One patient developed occlusive ileus caused by multiple polypoid tumours composed of sarcomatoid tissue in the jejunum shortly after nephrectomy. The other patient presented melaena due to bleeding from a Borrmann 2-like tumour in the jejunum six years after nephrectomy. Clinically, his disease was slow-growing. Sarcomatoid histology and Borrmann 2-like tumour in this report are rare findings in metastatic tumour of RCC in the small bowel. 相似文献
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54.
Narumi Tokaji Hiromichi Ito Tomohiro Kohmoto Takuya Naruto Rizu Takahashi Aya Goji Tatsuo Mori Yoshihiro Toda Masako Saito Shoichiro Tange Kiyoshi Masuda Shoji Kagami Issei Imoto 《American journal of medical genetics. Part A》2018,176(3):699-702
55.
Baum BJ Berkman ME Marmary Y Goldsmith CM Baccaglini L Wang S Wellner RB Hoque AT Atkinson JC Yamagishi H Kagami H Parlow AF Chao J 《Human gene therapy》1999,10(17):2789-2797
Previously (Kagami et al. Hum. Gene Ther. 1996;7:2177-2184) we have shown that salivary glands are able to secrete a transgene-encoded protein into serum as well as saliva. This result and other published data suggest that salivary glands may be a useful target site for vectors encoding therapeutic proteins for systemic delivery. The aim of the present study was to assess in vivo if transgene-encoded secretory proteins follow distinct, polarized sorting pathways as has been shown to occur "classically" in cell biological studies in vitro. Four first-generation, E1-, type 5 recombinant adenoviruses were used to deliver different transgenes to a rat submandibular cell line in vitro or to rat submandibular glands in vivo. Subsequently, the secretory distribution of the encoded proteins was determined. Luciferase, which has no signal peptide, served as a cell-associated, negative control and was used to correct for any nonspecific secretory protein release from cells. The three remaining transgene products tested, human tissue kallikrein (hK1), human growth hormone (hGH), and human alpha1-antitrypsin (halpha1AT), were predominantly secreted (>96%) in vitro. Most importantly, in vivo, after a parasympathomimetic secretory stimulus, both hK1 and hGH were secreted primarily in an exocrine manner into saliva. Conversely, halpha1AT was predominantly secreted into the bloodstream, i.e., in an endocrine manner. The aggregate results are consistent with the recognition of signals encoded within the transgenes that result in specific patterns of polarized protein secretion from rat submandibular gland cells in vivo. 相似文献
56.
Toyobuku H Sai Y Kagami T Tamai I Tsuji A 《The Journal of pharmacology and experimental therapeutics》2003,305(1):40-47
The feasibility of using adenovirus-mediated human oligopeptide transporter (hPEPT1) gene transfer to achieve peptide drug delivery to the brain across the blood-brain barrier was tested by examining the accumulation of model peptides in a rat brain endothelial cell line (RBEC1) and rat brain after transduction with a recombinant adenovirus encoding hPEPT1-enhanced yellow fluorescent protein fusion gene (AdhPEPT1-EYFP). In vitro uptake of [(3)H]GlySar was determined in RBEC1 transduced with AdhPEPT1-EYFP. In vivo, the accumulation of cefadroxil in rat brain was evaluated after transduction of AdhPEPT1-EYFP. At pH 6.0, the uptake of [(3)H]GlySar by RBEC1 transduced with AdhPEPT1-EYFP was increased 4-fold compared with that of nontransduced cells. At pH 7.4, uptake of [(3)H]GlySar in AdhPEPT1-EYFP transduced RBEC1 was 1.5 times higher than that of nontransduced cells. Unlabeled glycylsarcosine (10 mM) reduced the uptake of [(3)H]GlySar to a level comparable with that of nontransduced cells. At 30 min after intravenous administration of cefadroxil to rats transduced with AdhPEPT1-EYFP at 3.2 x 10(9) plaque-forming units/rat by an in situ brain perfusion method, the brain-to-plasma concentration ratio (Kp) of cefadroxil was increased about 2 times compared with that of nontransduced or AdGFP (control vector)-transduced rats, although this was not statistically significant. In contrast, Kp of [(14)C]inulin, a marker for extracellular fluid space, remained unchanged after adenoviral transduction. In conclusion, our results suggest that adenovirus-mediated heterologous expression of hPEPT1 in vivo could be a useful approach to deliver oligopeptides to the brain. 相似文献
57.
58.
Mieko Yamagata Kei Ikeda Kenji Tsushima Ken Iesato Mitsuhiro Abe Takashi Ito Daisuke Kashiwakuma Shin‐ichiro Kagami Itsuo Iwamoto Daiki Nakagomi Takao Sugiyama Yuichiro Maruyama Shunsuke Furuta David Jayne Takashi Uno Koichiro Tatsumi Hiroshi Nakajima 《Arthritis \u0026amp; Rheumatology》2016,68(3):713-723
59.
Kenichi Suga Shuji Kondo Sato Matsuura Yukiko Kinoshita Etsuko Kitano Michiyo Hatanaka Hajime Kitamura Yoshihiko Hidaka Takashi Oda Shoji Kagami 《Pediatric nephrology (Berlin, Germany)》2010,25(8):1547-1550
A 14-year-old girl presented with acute glomerulonephritis. Tests revealed hypocomplementemia and elevated Antistreptolysin-O
titers, and renal biopsy revealed endocapillary and mesangial proliferative glomerulonephritis with double contours of the
glomerular basement membrane (GBM). Despite methylprednisolone pulse therapy and the administration of oral prednisolone,
overt proteinuria and hypocomplementemia persisted. A second renal biopsy 6 months later confirmed the initial diagnosis of
dense deposit disease (DDD) based on electron-dense deposits in the GBM. C3 nephritic factor (C3NeF) and a deficiency of complement
factor H (CFH) were not evident. A nephritis-associated plasmin receptor (NAPlr), nephritogenic group A streptococcal antigen,
and the plasmin activity by in situ zymography were been in both the first and second biopsy specimens. The patient received
combined immunomodulatory therapy with prednisolone and mizoribine, and the urinary protein decreased to a mild level at 27 months
after disease onset. These findings suggest that persistent glomerular NAPlr deposition may be associated with the pathogenesis
of DDD in some patients without the involvement of C3NeF or CFH mutation and that DDD patients of this type may respond to
immunomodulatory treatment. 相似文献
60.
The linezolid treatment for methicillin-resistant Staphylococcus aureus (MRSA) infection was sporadically reported in children. Here we describe a case of a 6 month-old patient underwent mediastinal drainage and artificial conduit removement caused by MRSA infection. After that, linezolid treatment was started and bacteremia was resolved after 14 days of treatment. At discharge, he was no febrile, his blood culture were sterile. We report a case of a patient with MRSA endocarditis treatment with linezolid. 相似文献