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Waardenburg syndrome type IIE in a Japanese patient caused by a novel non‐frame‐shift duplication mutation in the SOX10 gene 下载免费PDF全文
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Yu Seri Norio Hanata Yasuo Nagafuchi Shuji Sumitomo Keishi Fujio 《Modern rheumatology / the Japan Rheumatism Association》2017,27(4):696-698
A 59-year-old man who presented with continuous fever, livedo reticularis, and left leg ischemia with multiple tibial artery stenosis and renal artery aneurysm, as demonstrated by arteriography, was diagnosed with polyarteritis nodosa (PAN) 6 years ago. Although he frequently relapsed in spite of intensive immunosuppressive therapies, the disease activity of PAN was controlled with repeated rituximab (RTX) therapies and steroid doses were tapered safely. Peripheral CD19+ B-cells disappeared soon after the 1st administration of RTX. Although CD19+ B-cells remained absent, 3.1% of CD3+CD20+ T-cells were observed in the peripheral blood prior to the 2nd administration of RTX. Recent studies have suggested the pathogenic role of CD3+CD20+ T-cells in autoimmune diseases in the context of RTX therapy; therefore, their roles in the pathogenesis of PAN also need to be considered. 相似文献
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Periodontal disease and pneumonia mortality in haemodialysis patients: A 7‐year cohort study 下载免费PDF全文
Masanori Iwasaki George W. Taylor Shuji Awano Akihiro Yoshida Shota Kataoka Toshihiro Ansai Hidetoshi Nakamura 《Journal of clinical periodontology》2018,45(1):38-45
Aim
To evaluate the association between periodontal disease and pneumonia mortality in haemodialysis patients.Materials and Methods
This prospective cohort study included 211 patients (mean age, 64.4 years) undergoing haemodialysis at a single medical centre. The patients underwent a baseline clinical dental examination in 2008 and were then followed up until July 2015. Periodontal disease was defined as the presence of clinical attachment loss of ≥4 mm in ≥30% of the probed sites. The primary endpoint, that is death from pneumonia, was determined by reviewing death certificates and was analysed using the competing‐risks regression model.Results
At baseline, 92 patients (43.6%) had periodontal disease. The median follow‐up period was 84 months (interquartile range, 36–86 months). Of the 68 deaths that occurred, 21 were from pneumonia. The multivariable competing‐risks regression model showed that periodontal disease was significantly associated with death from pneumonia (adjusted subhazard ratio, 3.49; 95% confidence interval, 1.14–10.64), after adjusting for other baseline health characteristics.Conclusions
The results of this study suggest that periodontal disease is independently associated with pneumonia mortality in haemodialysis patients. Future studies evaluating the potential effect of oral interventions for periodontal health improvement on pneumonia in haemodialysis patients would be of great interest. 相似文献80.
Diagnostic efficacy of liquid‐based cytology for solid pancreatic lesion samples obtained with endoscopic ultrasound‐guided fine‐needle aspiration: Propensity score‐matched analysis 下载免费PDF全文