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991.
Hannah Arem Mia Sorkin Brenda Cartmel Martha Fiellin Scott Capozza Maura Harrigan Elizabeth Ercolano Yang Zhou Tara Sanft Cary Gross Kathryn Schmitz Tuhina Neogi Dawn Hershman Jennifer Ligibel Melinda L. Irwin 《Journal of cancer survivorship》2016,10(4):654-662
Purpose
Up to 50 % of postmenopausal breast cancer survivors taking aromatase inhibitors (AIs) experience AI-associated arthralgias, or joint pain, which causes many to stop taking AIs and may inhibit exercise, despite known health benefits. We thus evaluated exercise adherence and factors associated with better exercise adherence in breast cancer survivors experiencing AI-induced arthralgia in the (HOPE) year long randomized controlled trial.Methods
We included 61 HOPE women randomized to exercise (150 min/week of moderate-intensity aerobic exercise and twice-weekly supervised strength training). Our main outcomes were aerobic exercise measured with daily activity logs, attendance at supervised exercise sessions, and changes in cardiorespiratory fitness, measured maximal oxygen consumption (VO2max). We examined means and standard deviations (SDs) for exercise adherence by demographic and medical characteristics and used the t test for mean differences. We also examined predictors of adherence using linear regression.Results
On average, at the end of the year long trial, women reported 119 (SD 78)?min/week of moderate-intensity aerobic exercise and participated in 70 % of supervised exercise training sessions. After adjustment for other factors that influence adherence, at 6 months postrandomization, only baseline VO2max was associated with higher aerobic exercise levels and at 12 months, only older age predicted better supervised exercise training attendance.Conclusions
Breast cancer survivors taking AIs and experiencing arthralgia are able to initiate and maintain a year long exercise program, regardless of other factors that influence activity levels.Implications for Cancer Survivors
Breast cancer survivors can exercise at levels that have been shown to improve AI-associated arthralgia.992.
Different induction of LPA receptors by chemical liver carcinogens regulates cellular functions of liver epithelial WB‐F344 cells 下载免费PDF全文
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Effect of a concomitant urologic procedure on outcomes following cytoreductive surgery with hyperthermic intraperitoneal chemotherapy 下载免费PDF全文
995.
Bernstein E Muratore-Schroeder TL Diaz RL Chow JC Changolkar LN Shabanowitz J Heard E Pehrson JR Hunt DF Allis CD 《Proceedings of the National Academy of Sciences of the United States of America》2008,105(5):1533-1538
Histone variants play an important role in numerous biological processes through changes in nucleosome structure and stability and possibly through mechanisms influenced by posttranslational modifications unique to a histone variant. The family of histone H2A variants includes members such as H2A.Z, the DNA damage-associated H2A.X, macroH2A (mH2A), and H2ABbd (Barr body-deficient). Here, we have undertaken the challenge to decipher the posttranslational modification-mediated "histone code" of mH2A, a variant generally associated with certain forms of condensed chromatin such as the inactive X chromosome in female mammals. By using female human cells as a source of mH2A, endogenous mH2A was purified and analyzed by mass spectrometry. Although mH2A is in low abundance compared with conventional histones, we identified a phosphorylation site, S137ph, which resides within the "hinge" region of mH2A. This lysine-rich hinge is an approximately 30-aa stretch between the H2A and macro domains, proposed to bind nucleic acids. A specific antibody to S137ph was raised; by using this reagent, S137 phosphorylation was found to be present in both male and female cells and on both splice variants of the mH2A1 gene. Although mH2A is generally enriched on the inactive X chromosome in female cells, mH2AS137ph is excluded from this heterochromatic structure. Thus, a phosphorylated subpopulation of mH2A appears to play a unique role in chromatin regulation beyond X inactivation. We provide evidence that S137ph is enriched in mitosis, suggestive of a role in the regulation of mH2A posttranslational modifications throughout the cell cycle. 相似文献
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PURPOSE: The purpose of this study was to examine what is currently known about diabetes education and care in rural geographical regions. Residents of rural areas are less likely to have access to health care providers, health insurance, or specialty care and are more likely to experience health care disparities as a result. Persons living in rural areas are likely to have greater burdens of chronic disease, including uncontrolled diabetes, and perceive their health as poorer than their urban counterparts. METHODS: A conventional literature review focused on type 1 and type 2 diabetes was completed using the search terms rural, diabetes, and education. The databases searched were CINAHL, EBSCO, Pub Med, and Medline. In all, 22 research articles that fit the inclusion criteria were identified. RESULTS: Findings indicated that diabetes education for rural regions can be enhanced by a focus on family, culture, interdisciplinary teams, and technology. CONCLUSIONS: Future rural research about diabetes care should carefully define rural, include gender-related studies that describe findings in terms of men and women, and focus on primary prevention. 相似文献
998.
Lagu T Weiner MG Hollenbeak CS Eachus S Roberts CS Schwartz JS Turner BJ 《Journal of general internal medicine》2008,23(8):1208-1213
Background Physician treatment of cardiovascular risk factors may be affected by specific types of patient comorbidities.
Objectives To examine the relationship between discordant comorbidities and LDL-cholesterol management in hypertensive patients not previously
treated with lipid-lowering therapy; to determine whether the presence of cardiovascular (concordant) conditions mediates
this relationship.
Design We performed a retrospective cohort study of 1,935 hypertensive primary care patients (men >45 years of age, women >55 years
of age) with documented elevated low-density lipoprotein (LDL) cholesterol and no lipid-lowering therapy at baseline. The
outcome was guideline-consistent hyperlipidemia management defined as optimal value on repeat LDL cholesterol testing or initiation
of lipid-lowering therapy. Using generalized estimating equations (GEE), we examined the association of concordant and discordant
comorbidities with guideline-consistent hyperlipidemia management over a 2-year follow-up period, adjusting for patient characteristics.
Results Guideline-consistent hyperlipidemia management was achieved in 1,236 patients (64%). In the fully adjusted model, each additional
discordant condition resulted in a 19% lower adjusted odds ratio of guideline-consistent hyperlipidemia management (p < 0.001)
when compared with no discordant conditions. The dampening effect of discordant conditions on guideline-consistent management
persisted even in the presence of concordant conditions, but each additional concordant condition was associated with a 37%
increase in the adjusted odds of guideline-consistent hyperlipidemia management (p < 0.001).
Conclusions In this cohort of hypertensive primary care patients, the number of conditions discordant with cardiovascular risk was strongly
negatively associated with guideline-consistent hyperlipidemia management even in patients at the highest risk for cardiovascular
events and cardiac death.
Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorized users. 相似文献
999.
Fogari R Derosa G Ferrari I Corradi L Zoppi A Lazzari P Santoro T Preti P Mugellini A 《American journal of hypertension》2008,21(9):1034-1039
BackgroundThis study compared the effect of antihypertensive treatment with valsartan or ramipril on atrial fibrillation (AF) recurrence, on P-wave dispersion, (PWD) and on serum procollagen type I carboxy terminal peptide (PIP).MethodsA total of 369 mild hypertensive (systolic blood pressure (SBP) >140 and/or 90 < diastolic blood pressure (DBP) < 110 mm Hg) outpatients in sinus rhythm but with at least two episodes of AF in the previous 6 months were randomized to valsartan (n = 122), ramipril (n = 124), or amlodipine (n = 123) for 1 year. Clinic blood pressure (BP) and a 24-h electrocardiogram (ECG) were evaluated monthly. Patients were asked to report any episode of symptomatic AF and to perform an ECG as early as possible. PWD and serum PIP levels were evaluated before and after each treatment period.ResultsSBP and DBP were significantly reduced by the three treatments (P < 0.001). A total of 46 (47.4%) patients treated with amlodipine had a recurrence of AF as did 26 (27.9%) patients treated with ramipril (P < 0.01 vs. amlodipine) and 16 (16.1%) patients treated with valsartan (P < 0.01 vs. amlodipine and P < 0.05 vs. ramipril). The Kaplan-Meyer analysis showed a significant reduction of AF episodes in the valsartan group (P = 0.005 log-rank test) as well as in the ramipril group (P = 0.021), even if at a lesser degree. PWD values were significantly reduced by ramipril (-4.2 ms, P < 0.05) and even more by valsartan (-11.2 ms, P < 0.01), the difference being significant (P < 0.01). Serum PIP levels were reduced by ramipril (-49.7 mug, P < 0.001) and valsartan (-49.3 mug, P < 0.001).ConclusionsDespite similar BP lowering, valsartan and ramipril were more effective than amlodipine in preventing new episodes of AF, but the effect of valsartan was greater than that of ramipril. This could be related to the greater PWD reduction observed with valsartan.American Journal of Hypertension (2008). doi:10.1038/ajh.2008.217American Journal of Hypertension (2008); 21, 9, 1034-1039. doi 10.1038/ajh.2008.217. 相似文献
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