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Abhishek Chaturvedi Randy Lau Gregory Kicska Gautham P. Reddy 《The international journal of cardiovascular imaging》2013,29(1):3-4
Congenital or acquired communication between left ventricle and right atrium is rare and can be easily overlooked as an eccentric tricuspid regurgitation jet. MRI is the ideal modality for accurate diagnosis, providing details for surgical planning about the location and size of the defect. 相似文献
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Wadi Mawad Rajiv R. Chaturvedi Greg Ryan Edgar Jaeggi 《The Canadian journal of cardiology》2018,34(3):342.e9-342.e11
We report the first ultrasonographically guided percutaneous balloon atrial septoplasty (BAS), to our knowledge, in a fetus with transposition of the great arteries and an intact ventricular and atrial septum (37 + 2 weeks). After vaginal delivery at 38 weeks, the infant had an elective septostomy (day 1) and an arterial switch procedure (day 7), with an uneventful postoperative course. For centres with experience in fetal cardiac interventions, fetal BAS is a superior management option compared with the alternatives for this high-risk physiology. 相似文献
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This article explores the application of narrative therapy to clinical work with clients’ adoption-related issues. The importance of therapist competency in addressing adoption-related issues is the primary focus for exploring the application of narrative therapy with individual, couple, and family clients experiencing adoption issues. The narrative method can be effective in exploring and understanding the diversity of experience and meanings adoption triad members report in regard to their adoption experiences (Baden & Wiley, 2007; Daniluk & Hurtig-Mitchell, 2003). Multiple realities and meanings emerge as a theme in the adoption literature and as core concepts in the narrative framework. 相似文献
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Francois Moisan Edgar B. Francisco Anamaria Brozovic George E. Duran Yan C. Wang Shalini Chaturvedi Shobha Seetharam Linda A. Snyder Parul Doshi Branimir I. Sikic 《Molecular oncology》2014,8(7):1231-1239
Ovarian cancer is associated with a leukocyte infiltrate and high levels of chemokines such as CCL2. We tested the hypothesis that CCL2 inhibition can enhance chemotherapy with carboplatin and paclitaxel. Elevated CCL2 expression was found in three non‐MDR paclitaxel resistant ovarian cancer lines ES‐2/TP, MES‐OV/TP and OVCAR‐3/TP, compared to parental cells. Mice xenografted with these cells were treated with the anti‐human CCL2 antibody CNTO 888 and the anti‐mouse MCP‐1 antibody C1142, with and without paclitaxel or carboplatin. Our results show an additive effect of CCL2 blockade on the efficacy of paclitaxel and carboplatin. This therapeutic effect was largely due to inhibition of mouse stromal CCL2. We show that inhibition of CCL2 can enhance paclitaxel and carboplatin therapy of ovarian cancer. 相似文献
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Shruti Chaturvedi Desiree Carcioppolo Li Zhang Keith R. McCrae 《American journal of hematology》2013,88(7):560-565
The advent of plasma exchange has led to a dramatic improvement in the survival of patients with thrombotic thrombocytopenic purpura (TTP), though approximately 10% of patients still die and a third suffer relapses. Clinical features that identify poor risk patients have not been clearly identified. We reviewed 100 patients who were treated for a first episode of TTP at the Cleveland Clinic between 2000 and 2012 to identify factors predictive of poor outcomes. On multivariate analysis, increasing age, especially age > 60 (RR: 7.08, 95% CI: 2.15–23.39, P = 0.002), severe neurological symptoms at presentation (RR: 18.37, 95% CI: I4.19–80.13, P < 0.001) and a persistently elevated LDH level after two plasma exchanges were predictive of mortality. Patients with ADAMTS13 activity above or below 5% did not differ in terms of clinical presentation or mortality and relapse rates, although ADAMTS13 activity > 5% was an independent predictor of adverse renal outcomes (need for dialysis and progression to chronic kidney disease). These variables may be useful for risk stratification and identification of patients who could potentially benefit from early institution of adjunctive therapy. Am. J. Hematol. 88:560–565, 2013. © 2013 Wiley Periodicals, Inc. 相似文献
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Kate M. Crossley Shruti Agnihotri Joga Chaganti Michael L. Rodriguez Leon Patrick McNally Nagagopal Venna Sarah E. Turbett Matthew Gutman Adrienne Morey Igor J. Koralnik Bruce J. Brew 《Journal of neurovirology》2016,22(4):541-545
We present two cases of recurrent progressive multifocal leukoencephalopathy (PML) in patients with long standing virally suppressed human immunodeficiency virus (HIV) and normal CD4+ T cell count who were taking stable regimens of highly active antiretroviral therapy (HAART). This has significant implications for other patients with a past history of PML, not just those with HIV but also those on medications such as natalizumab or fumarates. 相似文献
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