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101.
102.
Yasuhide Kitagawa Satoru Ueno Kouji Izumi Yoshifumi Kadono Atsushi Mizokami Shiro Hinotsu Hideyuki Akaza Mikio Namiki 《World journal of urology》2016,34(3):319-327
Purpose
To investigate the clinical outcomes of metastatic prostate cancer patients and the relationship between nadir prostate-specific antigen (PSA) levels and different types of primary androgen deprivation therapy (PADT). This study utilized data from the Japan Study Group of Prostate Cancer registry, which is a large, multicenter, population-based database.Methods
A total of 2982 patients treated with PADT were enrolled. Kaplan–Meier analysis was used to compare progression-free survival (PFS) and overall survival (OS) in patients treated using combined androgen blockade (CAB) and non-CAB therapies. The relationships between nadir PSA levels and PADT type according to initial serum PSA levels were also investigated.Results
Among the 2982 enrolled patients, 2101 (70.5 %) were treated with CAB. Although CAB-treated patients had worse clinical characteristics, their probability of PFS and OS was higher compared with those treated with a non-CAB therapy. These results were due to a survival benefit with CAB in patients with an initial PSA level of 500–1000 ng/mL. Nadir PSA levels were significantly lower in CAB patients than in non-CAB patients with comparable initial serum PSA levels.Conclusions
A small survival benefit for CAB in metastatic prostate cancer was demonstrated in a Japanese large-scale prospective cohort study. The clinical significance of nadir PSA levels following PADT was evident, but the predictive impact of PSA nadir on OS was different between CAB and non-CAB therapy.103.
104.
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Two patients with telescopic bites due to narrow mandibular arches were treated by mandibular widening and mandibular lengthening with intraoral distraction osteogenesis. Both patients underwent distraction osteogenesis surgery successfully, without any complications. The amount of widening in the 2 cases was 6 mm and 5 mm, and the intercanine distance increased by 2.1 mm and 4.9 mm, respectively. Nonextraction orthodontic treatment was performed after removal of the distraction devices in both cases. The postsurgical orthodontic treatment periods of the 2 cases were 13 months and 7 months, respectively. Eventually, functional occlusions and good profiles were obtained in both cases. Although both patients complained of temporomandibular joint symptoms at the first consultation, those symptoms were improved after treatment. At 3 years after debonding, dentofacial relapse was negligible. In conclusion, mandibular widening by intraoral distraction osteogenesis appeared to be an effective modality for correcting telescopic bites. 相似文献
106.
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109.
Kiyomi Matsuo Ichiro Morioka Mai Oda Yoko Kobayashi Yuji Nakamachi Seiji Kawano Miwako Nagasaka Tsubasa Koda Tomoyuki Yokota Satoru Morikawa Akihiro Miwa Akio Shibata Toshio Minematsu Naoki Inoue Hideto Yamada Kazumoto Iijima 《Brain & development》2014
Background
Infants with congenital cytomegalovirus infection (CCMVI) may develop brain abnormalities such as ventricular dilatation, which may potentially associate with sensorineural hearing loss. There is currently no recognized method for quantitative evaluation of ventricle size in infants with CCMVI. Our objectives were to establish a method for quantitative evaluation of ventricle size using computed tomography (CT) in infants with CCMVI, and determine a cut-off value associated with abnormal auditory brainstem response (ABR) early in life.Design/Subjects
This study enrolled 19 infants with CCMVI and 21 non-infected newborn infants as a control group. Infants with CCMVI were divided into two subgroups according to ABR at the time of initial examination: normal ABR (11 infants) or abnormal ABR (8 infants). Ventricle size was assessed by calculating Evans’ index (EI) and lateral ventricle width/hemispheric width (LVW/HW) ratio on brain CT images, and was compared among groups. A cut-off ventricle size associated with abnormal ABR was determined.Results
EI and LVW/HW ratio were significantly higher in the CCMVI with abnormal ABR group than the control and CCMVI with normal ABR groups. Cut-off values of 0.26 for EI and 0.28 for LVW/HW ratio had a sensitivity of 100% and 100%, respectively, and a specificity of 73% and 91%, respectively, for association with abnormal ABR.Conclusions
We established a method for quantitative evaluation of ventricle size using EI and LVW/HW ratio on brain CT images in infants with CCMVI. LVW/HW ratio had a more association with abnormal ABR in the early postnatal period than EI. 相似文献110.
Takao Saito Masayuki Iwano Koichi Matsumoto Tetsuya Mitarai Hitoshi Yokoyama Noriaki Yorioka Shinichi Nishi Ashio Yoshimura Hiroshi Sato Satoru Ogahara Hideki Shuto Yasufumi Kataoka Shiro Ueda Akio Koyama Shoichi Maruyama Masaomi Nangaku Enyu Imai Seiichi Matsuo Yasuhiko Tomino The Refractory Nephrotic Syndrome Study Group 《Clinical and experimental nephrology》2014,18(5):784-794