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991.
Design paper: Japan Endoscopy Database (JED): A prospective,large database project related to gastroenterological endoscopy in Japan
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Koji Matsuda Kiyohito Tanaka Mitsuhiro Fujishiro Yutaka Saito Kazuo Ohtsuka Ichiro Oda Chikatoshi Katada Masayuki Kato Mitsuhiro Kida Kiyonori Kobayashi Shu Hoteya Takahiro Horimatsu Shinya Kodashima Takahisa Matsuda Manabu Muto Hironori Yamamoto Shomei Ryozawa Ryuichi Iwakiri Hiromu Kutsumi Hiroaki Miyata Mototsugu Kato Ken Haruma Kazuma Fujimoto Naomi Uemura Michio Kaminishi Hisao Tajiri 《Digestive endoscopy》2018,30(1):5-19
The advent of electronic medical records brought image filing systems to many hospitals, as well as electronic endoscopic medical records. However, data integration among multiple different vendors has not yet been accomplished. We start the Japan Endoscopic Database (JED) Project endorsed by Japan Gastroenterological Endoscopy Society (JGES) from January 2015. The purposes of this project are as follows: (i) developing the world's largest endoscopic database generated from daily use of the reporting system; (ii) capturing the actual performance of endoscopic practice in Japan; and (iii) standardizing the terminology and fundamental items for registry of clinical studies. Moreover, the JED project has the potential to automatically collect data about adverse events, competency and evaluation of residents, and actual numbers of procedures on a nationwide scale, certification for the specialty board system, and so on. We believe that this design paper will be helpful not only for future nationwide research but also for international research (UMIN000016093). 相似文献
992.
Yuki Sahashi Nobuhiro Takasugi Genki Naruse Tomoki Kubota Kazuhiko Nishigaki Shinya Minatoguchi 《Journal of electrocardiology》2018,51(1):108-110
We present the case of a 62-year-old woman with levofloxacin-induced Torsade de Pointes, in whom microvolt T-wave alternans was measured during acute hospitalization and when QT interval was dynamically changing, illustrating a means for monitoring proarrhythmia. 相似文献
993.
994.
Sakiko Yoshida Teruki Miyake Shin Yamamoto Shinya Furukawa Tetsuji Niiya Hidenori Senba Sayaka Kanzaki Osamu Yoshida Toru Ishihara Mitsuhito Koizumi Masashi Hirooka Teru Kumagi Masanori Abe Kohichiro Kitai Bunzo Matsuura Yoichi Hiasa 《Journal of diabetes investigation.》2018,9(4):769-775
Aims/Introduction
The association between urine pH and abnormal glucose tolerance in men and women is unclear; therefore, we carried out a community‐based, cross‐sectional study to investigate sex‐specific associations between these values, possible indicators of prediabetes and type 2 diabetes.Materials and Methods
We enrolled 4,945 Japanese individuals (2,490 men and 2,455 women), who had undergone annual health checkups. To investigate the relationship between low urine pH and abnormal glucose tolerance, participants were divided into three groups based on their fasting plasma glucose levels (<6.11 mmol/L, 6.11–6.99 mmol/L and ≥6.99 mmol/L), and three groups based on their glycated hemoglobin levels (≤44.3 mmol/mol, 44.3–47.5 mmol/mol and ≥47.5 mmol/mol). To examine the effects of urine pH on abnormal glucose tolerance, participants were categorized into five groups based on their urine pH (5.0, 5.5, 6.0, 6.5 and ≥7.0).Results
Multivariate analysis adjusted for age, body mass index, systolic blood pressure, triglycerides, high‐density lipoprotein cholesterol, uric acid, creatinine and antidiabetic agent use showed significant associations between low urine pH and both high fasting plasma glucose and high glycated hemoglobin levels (P for trend = 0.0260, 0.0075) in men. Furthermore, after the same adjustments, prevalence rates of abnormal glucose tolerance (≥6.11 mmol/L and ≥6.99 mmol/L), increased significantly as urine pH levels decreased (P for trend = 0.0483, 0.0181) in men. In women, a similar trend was observed without a significant difference.Conclusions
Low urine pH is significantly associated with abnormal glucose tolerance; therefore, measuring urine pH might prove useful for identifying patients at high risk for diabetes. 相似文献995.
Dietary intake habits and the prevalence of nocturia in Japanese patients with type 2 diabetes mellitus
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996.
Shinya Sakata Yuichiro Matsuoka Kenta Kawahara Yosuke Kakiuchi Akira Takaki Akiyuki Hirosue Ryoji Yoshida Sho Saeki Kazuhiko Fujii Hideki Nakayama 《Respiratory investigation》2018,56(2):195-198
A 70-year-old Japanese man with recurrent squamous cell carcinoma of the head and neck presented with severe interstitial pneumonia associated with nivolumab, after talc slurry pleurodesis. Following the development of malignant pleural effusion, he underwent chest drainage and was administered intrathoracic talc as a pleurodesis. Two weeks later, we administered nivolumab (3 mg/kg) to be repeated every 2 weeks. However, on day 12, chest computed tomography scan demonstrated diffuse non-segmental ground-glass opacity and mild bronchiectasis. We diagnosed interstitial pneumonia associated with nivolumab. Although corticosteroid pulse therapy was initiated, the patient died of respiratory failure on day 14. 相似文献
997.
Haruo Nishijima MD PhD Tatsuya Ueno MD PhD Yukihisa Funamizu MD Shinya Ueno MD PhD Masahiko Tomiyama MD PhD 《Movement disorders》2018,33(6):877-888
Parkinson's disease (PD) is a neurodegenerative disorder associated with the progressive loss of nigrostriatal dopaminergic neurons. Levodopa is the most effective treatment for the motor symptoms of PD. However, chronic oral levodopa treatment can lead to various motor and nonmotor complications because of nonphysiological pulsatile dopaminergic stimulation in the brain. Examinations of autopsy cases with PD have revealed a decreased number of dendritic spines of striatal neurons. Animal models of PD have revealed altered density and morphology of dendritic spines of neurons in various brain regions after dopaminergic denervation or dopaminergic denervation plus levodopa treatment, indicating altered synaptic transmission. Recent studies using rodent models have reported dendritic spine head enlargement in the caudate‐putamen, nucleus accumbens, primary motor cortex, and prefrontal cortex in cases where chronic levodopa treatment following dopaminergic denervation induced dyskinesia‐like abnormal involuntary movement. Hypertrophy of spines results from insertion of alpha‐amino‐2,3‐dihydro‐5‐methyl‐3‐oxo‐4‐isoxazolepropanoic acid receptors into the postsynaptic membrane. Such spine enlargement indicates hypersensitivity of the synapse to excitatory inputs and is compatible with a lack of depotentiation, which is an electrophysiological hallmark of levodopa‐induced dyskinesia found in the corticostriatal synapses of dyskinetic animals and the motor cortex of dyskinetic PD patients. This synaptic plasticity may be one of the mechanisms underlying the priming of levodopa‐induced complications such as levodopa‐induced dyskinesia and dopamine dysregulation syndrome. Drugs that could potentially prevent spine enlargement, such as calcium channel blockers, N‐methyl‐D‐aspartate receptor antagonists, alpha‐amino‐2,3‐dihydro‐5‐methyl‐3‐oxo‐4‐isoxazolepropanoic acid receptor antagonists, and metabotropic glutamate receptor antagonists, are candidates for treatment of levodopa‐induced complications in PD. © 2017 International Parkinson and Movement Disorder Society 相似文献
998.
Novel electrophysiological criteria for septal ventricular outflow tract tachycardias requiring a sequential bilateral ablation
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Chin‐Yu Lin MD Fa‐Po Chung MD Yenn‐Jiang Lin MD PhD Shih‐Lin Chang MD PhD Li‐Wei Lo MD PhD Yu‐Feng Hu MD PhD Jo‐Nan Liao MD Ta‐Chuan Tuan MD Tze‐Fan Chao MD Yao‐Ting Chang MD Yun‐Yu Chen MPH Abigail Louise D. Te MD Shinya Yamada MD Ling Kuo MD Jennifer Jeanne B. Vicera MD Ting‐Yung Chang MD Hoang Quang Minh MD Simon Salim MD Ting‐Chung Huang MD Shih‐Ann Chen MD 《Journal of cardiovascular electrophysiology》2018,29(2):298-307
999.
Yuichiro Shirota Ristuko Hanajima Shinya Ohminami Ryosuke Tsutsumi Yoshikazu Ugawa Yasuo Terao 《Brain stimulation》2019,12(4):1020-1026
BackgroundThe masked-priming paradigm is used to test unconscious inhibitory processes of the brain. A tendency towards responses that are incompatible with the prime, designated as negative compatibility effect (NCE), emerges when the perception of a priming visual stimulus is “masked” afterwards. This effect presumably stems from a subliminal inhibitory process against the masked-prime. Prior lesions as well as activation studies suggest a key role of SMA in this effect.ObjectiveThis study was conducted to elucidate a causal role of SMA in the subliminal response inhibition represented by the NCE.MethodsUsing a repeated-measures pre–post design with a group of healthy people, physiological measures (resting and active motor thresholds and motor evoked potential (MEP) amplitude) and behavioral ones (choice reaction time (CRT), positive compatibility effect (PCE) and NCE) were obtained before and after three quadripulse stimulation (QPS), namely sham, M1-QPS, and SMA-QPS, on different days. CRT and PCE served as indices for different aspects of motor execution.ResultsMotor thresholds were not altered after any QPS, although the M1-QPS increased MEP amplitude. Neither CRT nor PCE was altered significantly after QPS protocols. NCE was abolished after the SMA-QPS.ConclusionsAbolished NCE after the SMA-QPS in the absence of MEP changes suggests that (1) SMA plays a cardinal role in the NCE, and (2) the network involved in NCE is different from that of MEP generation. 相似文献
1000.
Kazunobu Shinoda Shinya Morita Hirotaka Akita Fuyuki Washizuka Satoshi Tamaki Ryohei Takahashi Hideyo Oguchi Kei Sakurabayashi Toshihide Mizutani Yusuke Takahashi Yoji Hyodo Yoshihiro Itabashi Masaki Muramatsu Takeshi Kawamura Hiroshi Asanuma Eiji Kikuchi Masahiro Jinzaki Nobuyuki Shiraga Ken Sakai 《Transplantation proceedings》2019,51(5):1306-1310
BackgroundSecuring postdonation renal function in the lifetime of donors is a consequential subject for physicians, and precise prediction of postdonation renal function would be considerably beneficial when judging the feasibility of kidney donation. The aim of this study was to investigate the optimum model for predicting eGFR at 1 year after kidney donation.MethodsWe enrolled 101 living-related kidney donors for the development cohort and 44 for the external validation cohort. All patients in each cohort underwent thin-sliced (1 mm) enhanced computed tomography (CT) scans. We excluded individuals with diabetes, glucose intolerance, or albuminuria from this study. We evaluated preoperative factors including age, sex, hypertension, body mass index (BMI), serum uric acid, baseline eGFR, and body surface area (BSA)-adjusted preserved kidney volume (PKV) by using 3-dimensional reconstruction of thin-sliced enhanced CT images. To detect independent predictors, we performed multivariable regression analysis.ResultsThe multivariable regression analysis revealed that age, BMI, predonation eGFR, and BSA-adjusted PKV were independent predictors of eGFR at 1 year after kidney donation (correlation coefficient: ?0.15, ?0.476, 0.521, 0.127, respectively). A strong correlation between predicted eGFR and observed eGFR was obtained in the development cohort (r = 0.839, P < .0001). The significance of this predictive model was also confirmed with the external validation cohort (r = 0.797, P < .0001).ConclusionsAge, BMI, predonation eGFR, and BSA-adjusted PKV may be useful for precisely predicting eGFR at 1 year after living kidney donation and be helpful to determine the feasibility of kidney donation from marginal donors. 相似文献