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排序方式: 共有2173条查询结果,搜索用时 15 毫秒
91.
Yuko NAKAGAWA Akiomi INOUE Norito KAWAKAMI Kanami TSUNO Kimiko TOMIOKA Mayuko NAKANISHI Kosuke MAFUNE Hisanori HIRO 《Industrial health》2014,52(6):471-479
This study investigated the cross-sectional association of job demands (i.e.,
psychological demands) and job resources (i.e., decision latitude, supervisor support,
co-worker support, and extrinsic reward) with job performance. A total of 1,198 workers
(458 males and 740 females) from a manufacturing company in Japan completed a
self-administered questionnaire that included the Job Content Questionnaire, Effort-Reward
Imbalance Questionnaire, World Health Organization Health and Work Performance
Questionnaire, and demographic survey. Hierarchical multiple regression analyses were
conducted. After adjusting for demographic characteristics, decision latitude
(β=0.107, p=0.001) and
extrinsic reward (β=0.158,
p<0.001) were positively and significantly associated
with job performance while supervisor support (β=−0.102,
p=0.002) was negatively and significantly associated
with job performance. On the other hand, psychological demands or co-worker support was
not significantly associated with job performance. These findings suggest that higher
decision latitude and extrinsic reward enhance job performance among Japanese
employees. 相似文献
92.
Duc-Huy Chu Yoshihiro Sakoda Tatsuya Nishi Takahiro Hiono Shintaro Shichinohe Masatoshi Okamatsu Hiroshi Kida 《Vaccine》2014
H7N9 influenza virus infection in humans was reported in China on March 31, 2013. Humans are immunologically naïve to the H7N9 subtype, for which the seasonal influenza vaccine is not effective. Thus, the development of an H7N9 influenza virus vaccine is an urgent issue. To prepare for the emergence of an influenza pandemic, we have established a library comprising more than 1300 influenza virus strains with 144 different combinations of 16 HA and 9 NA subtypes. An H7N9 virus strain isolated from a 35-year-old woman, A/Anhui/1/2013 (H7N9), was found to be antigenically similar to H7N9 influenza viruses isolated from migratory ducks. In the present study, the potency of an inactivated whole virus particle vaccine prepared from an H7N9 low pathogenic avian influenza virus, A/duck/Mongolia/119/2008 (H7N9), selected from the library, was assessed by a challenge with A/Anhui/1/2013 (H7N9). The results indicate that the test vaccine was potent enough to induce sufficient immunity to reduce the impact of disease caused by the challenge with A/Anhui/1/2013 (H7N9) in mice. The present results indicate that an inactivated whole virus particle vaccine prepared from an influenza virus strain stored in the library could be useful as a vaccine strain in case of an influenza pandemic. 相似文献
93.
Ryo Wada MD PhD Masaya Shinohara MD PhD Tadashi Fujino MD PhD Shingo Matsumoto MD PhD Shintaro Yao MD PhD Kensuke Yano MD Shintaro Dobashi MD PhD Katsuya Akitsu MD PhD Hideki Koike MD PhD Hiroshi Ohara MD PhD Toshio Kinoshita MD PhD Hitomi Yuzawa MD PhD Rine Nakanishi MD PhD Takanori Ikeda MD PhD 《Pacing and clinical electrophysiology : PACE》2023,46(1):73-83
94.
Junji Iwasaki Taku Iida Masaki Mizumoto Tadahiro Uemura Shintaro Yagi Tomohide Hori Kohei Ogawa Yasuhiro Fujimoto Akira Mori Toshimi Kaido Shinji Uemoto 《Transplant international》2014,27(11):1205-1213
This study investigated adequate liver graft selection for donor safety by comparing postoperative donor liver function and morbidity between the right and left hemilivers (RL and LL, respectively) of living donors. Between April 2006 and March 2012, RL (n = 168) and LL (n = 140) donor operations were performed for liver transplantation at Kyoto University Hospital. Postoperative hyperbilirubinemia and coagulopathy persisted in RL donors, whereas the liver function of LL donors normalized more rapidly. The overall complication rate of the RL donors was significantly higher than that of the LL donors (59.5% vs. 30.7%; P < 0.001). There were no significant differences in severe complications worse than Clavien grade IIIa or in biliary complication rates between the two donor groups. In April 2006, we introduced an innovative surgical procedure: hilar dissection preserving the blood supply to the bile duct during donor hepatectomy. Compared with our previous outcomes (1990–2006), the biliary complication rate of the RL donors decreased from 12.2% to 7.2%, and the severity of these complications was significantly lower. In conclusion, LL donors demonstrated good recovery in postoperative liver function and lower morbidity, and our surgical innovations reduced the severity of biliary complications in living donors. 相似文献
95.
Tomoko Miki Osamu Yokota Takashi Haraguchi Hideki Ishizu Masato Hasegawa Takeshi Ishihara Shu‐ichi Ueno Shintaro Takenoshita Seishi Terada Norihito Yamada 《Brain pathology (Zurich, Switzerland)》2020,30(4):811-830
Granular/fuzzy astrocytes (GFAs), a subtype of “aging‐related tau astrogliopathy,” are noted in cases bearing various neurodegenerative diseases. However, the pathogenic significance of GFAs remains unclear. We immunohistochemically examined the frontal cortex, caudate nucleus, putamen and amygdala in 105 cases composed of argyrophilic grain disease cases (AGD, N = 26), and progressive supranuclear palsy (PSP, N = 10), Alzheimer’s disease (AD, N = 20) and primary age‐related tauopathy cases (PART, N = 18) lacking AGD, as well as 31 cases bearing other various neurodegenerative diseases to clarify (i) the distribution patterns of GFAs in AGD, and PSP, AD and PART lacking AGD, (ii) the impacts of major pathological factors and age on GFA formation and (iii) immunohistochemical features useful to understand the formation process of GFAs. In AGD cases, GFAs consistently occurred in the amygdala (100%), followed by the putamen (69.2%) and caudate nucleus and frontal cortex (57.7%, respectively). In PSP cases without AGD, GFAs were almost consistently noted in all regions examined (90–100%). In AD cases without AGD, GFAs were less frequent, developing preferably in the putamen (35.0%) and caudate nucleus (30.0%). PART cases without AGD had GFAs most frequently in the amygdala (35.3%), being more similar to AGD than to AD cases. Ordered logistic regression analyses using all cases demonstrated that the strongest independent factor of GFA formation in the frontal cortex and striatum was the diagnosis of PSP, while that in the amygdala was AGD. The age was not significantly associated with GFA formation in any region. In GFAs in AGD cases, phosphorylation and conformational change of tau, Gallyas‐positive glial threads indistinguishable from those in tufted astrocytes, and the activation of autophagy occurred sequentially. Given these findings, AGD, PSP, AD and PART cases may show distinct distributions of GFAs, which may provide clues to predict the underlying processes of primary tauopathies. 相似文献
96.
Toshifumi Suzuki MD PhD Yuka Yamamoto MD PhD Hiroki Nakamura MD PhD Kiguna Sei-Okawa MD PhD Yojiro Maruyama MD PhD Jun Takeda MD PhD Shintaro Makino MD PhD Atsuyuki Yamataka MD PhD Atsuo Itakura MD PhD 《Journal of clinical ultrasound : JCU》2020,48(3):181-183
Omphalocele is rarely complicated by umbilical cord cysts. In our case, an umbilical cord cyst and fetal ascites were detected at 26 weeks' gestation in a fetus with trisomy 13. This changed to omphalocele with subsequently absorbed fetal ascites at 35 weeks' gestation. We propose two hypotheses. The abdominal wall may have been physically pierced or an omphalocele might have preexisted, and the intestinal tract in the hernia sac was pushed by fetal ascites. 相似文献
97.
Yuichi Goto Shintaro Kawano Ryota Matsubara Takahiro Kiyosue Mitsuhiro Hirano Teppei Jinno Yasuyuki Maruse Takeshi Toyoshima Ryoji Kitamura Hideaki Tanaka Kazunari Oobu Seiji Nakamura 《Clinical & experimental metastasis》2014,31(3):293-306
Epithelial-to-mesenchymal transition (EMT), an essential developmental program, is involved in tumor progression. ΔNp63, a homolog of p53, is associated with the EMT program, but the detailed mechanism remains to be elucidated. In this study, we investigated the role of ΔNp63 in EMT during progression of oral squamous cell carcinoma (OSCC). Five OSCC cell lines and specimens from 78 patients with OSCC were used. The expressions of ΔNp63, p63α, p63β and epithelial markers (cytokeratins 5 and 14) was detected in the OSCC cells, but not in SQUU-B cells (high metastatic potential). E-cadherin was expressed in all OSCC cells. Mesenchymal markers were strongly expressed in the SQUU-B cells. Knockdown of endogenous ΔNp63 in HSC-2 cells induced morphological changes to the spindle shape, decreased the expression of epithelial markers, increased the expression of mesenchymal markers, increased migration and reduced proliferation. By contrast, SQUU-B cells overexpressing ΔNp63β showed changed their morphology from stromal cell-like to epithelial cells. However, E-cadherin expression was not affected by ΔNp63 knockdown or overexpression. Immunohistochemical staining revealed that cancer cells expressing vimentin were found at the invasive front in the OSCC specimens. The intensity of ΔNp63 expression was also decreased in these cells. Interestingly, the vimentin positivity or decreased intensity of ΔNp63 was positively associated with metastases and poor prognosis in the OSCC patients. These results indicated that ΔNp63 downregulation in cancer cells induces a mesenchymal phenotype that is related to tumor progression of OSCC. 相似文献
98.
99.