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101.
102.
Hiroki Ashizawa Kazuko Yamamoto Nobuyuki Ashizawa Kazuaki Takeda Naoki Iwanaga Takahiro Takazono Noriho Sakamoto Makoto Sumiyoshi Shotaro Ide Asuka Umemura Masataka Yoshida Yuichi Fukuda Tsutomu Kobayashi Masato Tashiro Takeshi Tanaka Shungo Katoh Konosuke Morimoto Koya Ariyoshi Shimpei Morimoto Mya Myat Ngwe Tun Shingo Inoue Kouichi Morita Shintaro Kurihara Koichi Izumikawa Katzunori Yanagihara Hiroshi Mukae 《Viruses》2022,14(2)
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by the SFTS virus. It involves multiple organ systems, including the lungs. However, the significance of the lung involvement in SFTS remains unclear. In the present study, we aimed to investigate the relationship between the clinical findings and abnormalities noted in the chest computed tomography (CT) of patients with SFTS. The medical records of 22 confirmed SFTS patients hospitalized in five hospitals in Nagasaki, Japan, between April 2013 and September 2019, were reviewed retrospectively. Interstitial septal thickening and ground-glass opacity (GGO) were the most common findings in 15 (68.1%) and 12 (54.5%) patients, respectively, and lung GGOs were associated with fatalities. The SFTS patients with a GGO pattern were elderly, had a disturbance of the conscious and tachycardia, and had higher c-reactive protein levels at admission (p = 0.009, 0.006, 0.002, and 0.038, respectively). These results suggested that the GGO pattern in patients with SFTS displayed disseminated inflammation in multiple organs and that cardiac stress was linked to higher mortality. Chest CT evaluations may be useful for hospitalized patients with SFTS to predict their severity and as early triage for the need of intensive care. 相似文献
103.
104.
105.
Motohiro Akagi K. Inui Toshinori Nishigaki Takashi Muramatsu Chikara Kokubu L. Fu Hisao Fukushima Itaru Yanagihara Hiroko Tsukamoto Hiroki Kurahashi Shintaro Okada 《Journal of human genetics》1999,44(5):323-326
Fucosidosis is a rare autosomal recessive disorder resulting from a deficiency of α-L-fucosidase. Recently, various mutations
have been reported in this disease, but it is difficult to elucidate the phenotype from the genetic mutations. We report a
patient with chronic infantile type fucosidosis, with a compound heterozygote of a nonsense mutation (W148X, Trp at codon
148 to stop codon) and a large deletion, including all exons. This is the first report of a large deletion demonstrated in
fucosidosis. It is interesting that this patient has a relatively mild clinical course despite the absence of the mRNA. This
case also indicates the difficulty in determining the phenotype from the genotype in fucosidosis.
Received: February 19, 1999 / Accepted: April 16, 1999 相似文献
106.
Maintenance of CD8+ memory T lymphocytes in the spleen but not in the bone marrow is dependent on proliferation
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Francesco Siracusa Özen Sercan Alp Patrick Maschmeyer Mairi McGrath Mir‐Farzin Mashreghi Shintaro Hojyo Hyun‐Dong Chang Koji Tokoyoda Andreas Radbruch 《European journal of immunology》2017,47(11):1900-1905
It is current belief that numbers of CD8+ memory T lymphocytes in the memory phase of an immune response are maintained by homeostatic proliferation. Here, we compare the proliferation of CD8+ memory T lymphocytes, generated by natural infections and by intentional immunization, in spleen and bone marrow (BM). Fifty percent of CD8+ memory T lymphocytes in the spleen are eliminated by cyclophosphamide within 14 days, indicating that numbers of at least 50% of splenic CD8+ memory T lymphocytes are maintained by proliferation. The numbers of CD8+ memory T lymphocytes in the BM, however, were not affected by cyclophosphamide. This stability was independent of circulating CD8+ memory T cells, blocked by FTY720, showing that BM is a privileged site for the maintenance of memory T lymphocytes, as resident cells, resting in terms of proliferation. 相似文献
107.
Kawai T Takahashi K Sato S Coban C Kumar H Kato H Ishii KJ Takeuchi O Akira S 《Nature immunology》2005,6(10):981-988
108.
Taki S Terahata S Yamashita R Kinuya K Nobata K Kakuda K Kodama Y Yamamoto I 《Clinical imaging》2004,28(5):368-371
We investigated the incidence of cancer in surgically resected 151 thyroid nodules in 101 patients according to their calcification patterns on preoperative ultrasonography (US). Calcification was detected in 57 (38%) nodules, 31 (54%) of which was histologically diagnosed as cancer. According to the calcification types, 9 of 11 nodules with microcalcifications, 15 of 29 nodules with intranodular coarse calcification, 6 of 14 nodules with peripheral calcification and 1 of 3 calcified spots without surrounding tumor were diagnosed as cancer. 相似文献
109.
Takahiko Sakuma Yuji Higashibata Hirohisa Kawahata Shuichi Yamada Masaru Okabe Yukihiko Kitamura Shintaro Nomura 《Journal of orthopaedic science》2003,8(3):361-366
Osteopontin is a sialoprotein that is expressed in various cells. It plays a variety of important roles in cell adhesion,
migration, signaling, calcification, and immunity. Its diverse functions indicate that the regulation of osteopontin may also
vary extensively among tissues. Although osteopontin promoter has been studied in vitro, in vivo analyses may be more appropriate
for elucidating osteopontin's functions. In an attempt to investigate osteopontin gene expression, we generated transgenic
mice in which the bacterial β-galactosidase reporter gene was conjugated downstream of osteopontin promoter. The osteopontin
promoter was a mouse −910 bp upstream fragment, which we had previously found functional in 3T3 cells. Among 34 transgenic
founders, 13 mice were transgenic, as determined with the polymerase chain reaction. Osteopontin and β-galactosidase signals
were evaluated with in situ hybridization. Among the 13 transgenic mice, 3 were β-galactosidase-positive. In these transgenic
mice, osteopontin signals were observed in bones and kidneys, whereas β-galactosidase message was detected only in bones.
This suggests that the −910 bp osteopontin promoter is active in bones but not in kidneys. These data imply that the promoter
region required for osteopontin expression in kidneys may differ from that in bones.
Received: March 22, 2002 / Accepted: December 5, 2002
RID="*"
ID="*" Offprint requests to: T. Sakuma
Acknowledgments. We greatly appreciate the excellent histotechnological assistance of Mr. Kenji Morihana. This work was supported in part
by a grant from The Ministry of Education, Science, and Culture, Japan (no. 12470056). 相似文献
110.
Second Hepatic Resection for Recurrent Hepatocellular Carcinoma in Patients with Chronic Hepatitis C
Kubo S Takemura S Uenishi T Yamamoto T Ohba K Ogawa M Hai S Ichikawa T Kodai S Shinkawa H Tanaka H 《World journal of surgery》2008,32(4):632-638
Background Although a second hepatic resection (SHR) for recurrent hepatocellular carcinoma (HCC) is widely accepted, the indications
for SHR have not been established. The risk factors for HCC recurrence after SHR were evaluated to investigate the indications
for SHR.
Methods Subjects included 51 patients who underwent a second hepatic resection for recurrence of HCV-related HCC. Sixteen patients
received interferon therapy before or after the first operation. Six patients attained a sustained viral response (SVR) that
was defined as return of the alanine aminotransferase (ALT) activity to within the reference range and no detectable serum
HCV RNA for at least 1 year after interferon therapy. A biochemical response (BR), defined as a normalized ALT activity for
at least 1 year after interferon therapy with or without the transient disappearance of serum HCV RNA, was attained in three
patients. The other seven patients were defined as the nonresponse (NR) group.
Results By univariate analysis, NR and lack of interferon therapy, high indocyanine green retention rate at 15 min (ICGR15), high
aspartate aminotransferase activity, high ALT activity, large tumor, and multiple tumors were risk factors for HCC recurrence
after SHR. By multivariate analysis, NR and lack of interferon therapy, high ICGR15, large tumor, and multiple tumors were
independent risk factors.
Conclusions Patients in whom active hepatitis has been controlled by interferon therapy are the best candidates for SHR. Interferon therapy
should be recommended in patients undergoing resection of an HCV-related HCC because SHR can prolong life in SVR and BR patients. 相似文献