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101.
Katsuhiko Iwakiri Hidenori Kanazawa Satoshi Matsuzaka Norihiko Tada Hitoshi Saitoh Hitoshi Yoshimoto Yoshiya Nakagawa Yuuji Osada Toshiaki Sugiura Makoto Kotoyori Yasutaka Mamiya Hisagi Yamada Yoshiyuki Narahara Akihiko Kawakami Masafumi Kobayashi 《Journal of gastroenterology》1998,33(3):305-309
The effects of transjugular intrahepatic portosystemic shunt (TIPS) placement on esophageal motor function and gastroesophageal
reflux were investigated in patients with esophageal varices. In six men with esophageal varices, esophageal manometry and
upper gastrointestinal endoscopy were performed before and 15–20 days after TIPS placement. Intraesophageal pH monitoring
was performed in the four patients with severe esophageal varices (defined as the largest sized varices) following TIPS placement.
Findings were compared with those in six healthy men (controls) who underwent esophageal manometry and intraesophageal pH
monitoring. The esophageal varices resolved or were reduced after TIPS placement. Resting lower esophageal sphincter (LES)
pressures were similar in the study group before and after TIPS placement and in the control subjects. The incidence and progression
of esophageal contractions were similar in the study group before and after TIPS placement and in the control subjects. At
3 cm above the LES, the amplitude of esophageal contraction after TIPS placement was significantly higher than that before
TIPS placement. At 3 and 8 cm above the LES, the amplitude of esophageal contraction in the control subjects was significantly
higher than that in the study group before and after TIPS placement. Esophageal acid exposure time after TIPS placement was
similar to that in the controls. TIPS placement is a useful treatment that improves esophageal motor function without the
occurrence of pathologic gastroesophageal reflux.
(Received May 28, 1997; accepted Sept. 26, 1997) 相似文献
102.
103.
Hiroshi Tada Kenji Kurosaki Sachiko Ito Shigeto Naito Minoru Yamada Kohei Miyaji Tohru Hashimoto Shigeru Oshima Akihiko Nogami Koichi Taniguchi 《Circulation journal》2005,69(7):865-869
A patient underwent radiofrequency (RF) catheter ablation of symptomatic idiopathic ventricular contractions (PVCs). RF energy applications at 2 sites in the right ventricular outflow tract (RVOT), where both the earliest ventricular activation and near-perfect pace mapping were obtained, did not abolish the PVC but resulted in changes in the QRS morphology of the PVC. Complete elimination of the PVC was achieved with RF energy application at a site within the pulmonary artery 13 mm above the pulmonary valve, which was greater than 20 mm away from the failed ablation sites within the RVOT. 相似文献
104.
105.
106.
Yoshiyuki Abe Ken Yamaji Yukari Endo Makio Kusaoi Soichiro Nakano Kwang‐Seok Yang Kurisu Tada Hiroshi Tsuda Naoto Tamura 《Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy》2020,24(2):208-214
Diffuse alveolar hemorrhage (DAH) is well known as a serious complication of microscopic polyangiitis (MPA). We examined the effectiveness of plasma exchange (PLEX) therapy to reduce mortality in Japanese DAH patients with MPA. This retrospective, double‐center, observational cohort study included 20 DAH patients with MPA who were admitted to Juntendo University Hospital or Juntendo Koto Geriatric Medical Center between April 1998 and March 2018. The primary outcome was non–disease‐specific mortality. The 1‐year survival rate of patients with PLEX therapy (N = 4) was higher than that of patients with conventional therapy (N = 16, 75% and 13%, respectively, P = 0.037). Higher values of the 1996 Five‐Factor Score (FFS) and 2009 FFS were associated with increased mortality, with hazard ratios of 2.29 (P = 0.040) and 2.41 (P = 0.043), respectively, by Cox univariate analysis. We investigated PLEX therapy for reducing mortality in DAH patients with MPA, and the 1996 FFS and 2009 FFS were both independent prognostic factors. 相似文献
107.
Nobuhiro Yoshijima Ryo Yanagisawa Hiromu Hase Makoto Tanaka Hikaru Tsuruta Hideyuki Shimizu Keiichi Fukuda Toru Naganuma Kazuki Mizutani Motoharu Araki Norio Tada Futoshi Yamanaka Shinichi Shirai Minoru Tabata Hiroshi Ueno Kensuke Takagi Akihiro Higashimori Yusuke Watanabe Masanori Yamamoto Kentaro Hayashida 《Catheterization and cardiovascular interventions》2020,95(1):35-44
108.
Kenji Hirano Hiroyuki Isayama Minoru Tada Kazuhiko Koike 《Clinical journal of gastroenterology》2014,7(3):200-204
Chronic inflammatory diseases are often associated with malignancy, and this phenomenon occurs even in the field of gastroenterology. For example, chronic pancreatitis has been reported to be highly associated with the occurrence of pancreatic cancer. However, the association between autoimmune pancreatitis (AIP) and pancreatic cancer is still an unsolved problem. As AIP is associated with immunoglobulin G4-related disease, which causes a variety of inflammatory and fibrotic lesions, the association between AIP and total malignancies is also a matter of interest. Here, we discuss the association between AIP and malignancy. As for the association between AIP and pancreatic cancer, there is no conclusive evidence, although several reports have suggested that the relative risk of pancreatic cancer is high in AIP. Concerning the association between AIP and total malignancies, there are two reports from Japan. Neither report supported the idea that chronic inflammation in AIP caused the increased risk of total malignancies. However, one report proposed the possibility that AIP might develop as a paraneoplastic syndrome in some patients because many cancers occurred within 1 year of AIP diagnosis, and thereby concluded that patients with AIP were at high risk of having various cancers. The paraneoplastic syndrome hypothesis should be tested in future studies. 相似文献
109.
Milk fat globule-epidermal growth factor 8 (MFG-E8), a glycoprotein secreted from various cells, enhances engulfment of apoptotic cells by forming a link between phosphatidylserine on apoptotic cells and α(v)β(3)-integrin on phagocytes. This process is essential for maintaining the host immune system under physiological conditions. Apart from this scavenging function, MFG-E8 also directly regulates a variety of cellular functions, such as attenuating inflammation and healing of injured tissues. Furthermore, recent studies have revealed that MFG-E8 has anti-inflammatory and regenerating roles during intestinal inflammation. This review highlights novel findings regarding the roles of MFG-E8 in intestinal pathophysiology as well as its therapeutic potential for gut inflammatory disorders. 相似文献
110.
Ochi H Hirooka M Koizumi Y Miyake T Tokumoto Y Soga Y Tada F Abe M Hiasa Y Onji M 《Hepatology (Baltimore, Md.)》2012,56(4):1271-1278
The aim of this study was to prospectively measure liver stiffness with real-time tissue elastography in patients with nonalcoholic fatty liver diseases (NAFLD) and to compare the result with the clinical assessment of fibrosis using histological stage. One hundred and eighty-one prospectively enrolled patients underwent real-time tissue elastography, with the first 106 being analyzed as the training set and the remaining 75 being evaluated as the validation set. Hepatic and splenic elastic ratios were calculated and compared with stage of histological fibrosis. Portal hypertension (PH) was assessed. Real-time tissue elastography cut-off values by stage in the training set were 2.47 for F1, 2.67 for F2, 3.02 for F3, and 3.36 for F4. Using these cut-off values, the diagnostic accuracy of hepatic fibrosis in the validation set was 82.6%-96.0% in all stages. Only portal fibrosis correlated with the hepatic elastic ratio by multivariate analysis. The area under the receiver operating characteristic curve of elastic ratio better correlated than serum fibrosis markers in both early and advanced fibrosis stages. Patients with PH, defined by splenic elasticity, had early fibrosis. Patients with severe PH were found only in the group with cirrhosis. Conclusion: Real-time tissue elastography is useful in evaluating hepatic fibrosis and PH in patients with NAFLD. (HEPATOLOGY 2012). 相似文献