全文获取类型
收费全文 | 10196篇 |
免费 | 530篇 |
国内免费 | 81篇 |
专业分类
耳鼻咽喉 | 121篇 |
儿科学 | 140篇 |
妇产科学 | 61篇 |
基础医学 | 1195篇 |
口腔科学 | 152篇 |
临床医学 | 630篇 |
内科学 | 2665篇 |
皮肤病学 | 450篇 |
神经病学 | 817篇 |
特种医学 | 439篇 |
外科学 | 2127篇 |
综合类 | 39篇 |
预防医学 | 281篇 |
眼科学 | 68篇 |
药学 | 515篇 |
中国医学 | 12篇 |
肿瘤学 | 1095篇 |
出版年
2023年 | 72篇 |
2022年 | 128篇 |
2021年 | 221篇 |
2020年 | 128篇 |
2019年 | 167篇 |
2018年 | 226篇 |
2017年 | 188篇 |
2016年 | 213篇 |
2015年 | 248篇 |
2014年 | 314篇 |
2013年 | 408篇 |
2012年 | 607篇 |
2011年 | 671篇 |
2010年 | 365篇 |
2009年 | 294篇 |
2008年 | 547篇 |
2007年 | 651篇 |
2006年 | 610篇 |
2005年 | 627篇 |
2004年 | 619篇 |
2003年 | 606篇 |
2002年 | 625篇 |
2001年 | 183篇 |
2000年 | 190篇 |
1999年 | 183篇 |
1998年 | 138篇 |
1997年 | 116篇 |
1996年 | 98篇 |
1995年 | 100篇 |
1994年 | 80篇 |
1993年 | 60篇 |
1992年 | 124篇 |
1991年 | 135篇 |
1990年 | 97篇 |
1989年 | 110篇 |
1988年 | 91篇 |
1987年 | 91篇 |
1986年 | 73篇 |
1985年 | 57篇 |
1984年 | 54篇 |
1983年 | 51篇 |
1982年 | 26篇 |
1980年 | 16篇 |
1979年 | 19篇 |
1978年 | 17篇 |
1976年 | 14篇 |
1975年 | 14篇 |
1969年 | 13篇 |
1967年 | 12篇 |
1966年 | 13篇 |
排序方式: 共有10000条查询结果,搜索用时 78 毫秒
161.
162.
163.
Kazumi Urata Ikko Kajihara Tselmeg Mijiddorj Myangat Yukino Tasaki Saki Otsuka‐Maeda Soichiro Sawamura Saori Kanazawa‐Yamada Ryoko Sakamoto Katsunari Makino Jun Aoi Toshikatsu Igata Takamitsu Makino Shinichi Masuguchi Satoshi Fukushima Masatoshi Jinnin Hironobu Ihn 《The Journal of dermatology》2019,46(5):444-448
Cyclin‐dependent kinase 4 and 6 (CDK4/6) plays an important role in cell cycle progression, and the CDK4/6–cyclin D1 complex controls the cell cycle transition from G1 phase to S phase. CDK4 is enhanced in several types of cancers and CDK4/6 inhibitors attenuate the proliferation of several types of cancer in vitro/in vivo. The purpose of our study was to investigate the expression pattern of CDK4 and evaluate its clinical importance in extramammary Paget's disease (EMPD). Almost all EMPD tissues were positive for CDK4, and metastatic lesions had a similar immunostaining intensity to primary lesions. In addition, CDK4 protein levels were positively correlated with those of cyclin D1 protein. Taken together, CDK4 may assume a crucial role in EMPD progression. 相似文献
164.
Shuichi Ota Toshihiro Matsukawa Satoshi Yamamoto Shinichi Ito Motohiro Shindo Kazuya Sato Takeshi Kondo Kyuhei Kohda Hajime Sakai Akio Mori Tohru Takahashi Hiroshi Ikeda Hiroyuki Kuroda Yoshihito Haseyama Masaki Yamamoto Takeo Sarashina Makoto Yoshida Ryoji Kobayashi Mitsufumi Nishio Toshimichi Ishihara Yasuo Hirayama Yasutaka Kakinoki Hajime Kobayashi Takashi Fukuhara Masahiro Imamura Mitsutoshi Kurosawa 《European journal of haematology》2018,101(1):95-105
165.
166.
167.
Diagnostic efficacy of liquid‐based cytology for solid pancreatic lesion samples obtained with endoscopic ultrasound‐guided fine‐needle aspiration: Propensity score‐matched analysis
下载免费PDF全文
![点击此处可从《Digestive endoscopy》网站下载免费的PDF全文](/ch/ext_images/free.gif)
168.
Possible pro‐inflammatory role of heparin‐binding epidermal growth factor‐like growth factor in the active phase of systemic sclerosis
下载免费PDF全文
![点击此处可从《The Journal of dermatology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Megumi Hirabayashi Yoshihide Asano Takashi Yamashita Shunsuke Miura Kouki Nakamura Takashi Taniguchi Ryosuke Saigusa Takehiro Takahashi Yohei Ichimura Takuya Miyagawa Ayumi Yoshizaki Tomomitsu Miyagaki Makoto Sugaya Shinichi Sato 《The Journal of dermatology》2018,45(2):182-188
Heparin‐binding epidermal growth factor (EGF)‐like growth factor (HB‐EGF) is a member of the EGF family growth factors, which affects multiple aspects of the wound healing process such as epithelialization, wound contraction and angiogenesis. In our study, we measured the serum HB‐EGF levels of 51 systemic sclerosis (SSc) patients, which showed a significant increase compared with those of 20 normal subjects. Further analysis revealed a positive correlation between the HB‐EGF level and pulmonary ground‐glass score but no correlation between the former and pulmonary fibrosis score. Other findings include: a significant increase of serum sialylated carbohydrate antigen KL‐6 levels and significant shortness of disease duration in the diffuse cutaneous SSc patients with elevated HB‐EGF levels; and significantly higher HB‐EGF levels in the presence of Raynaud's phenomenon, in that of telangiectasia, and in the absence of contracture of phalanges in all SSc patients. We then evaluated HB‐EGF mRNA levels of fibroblasts harvested from skin samples of the SSc patients and those of foreskin‐derived fibroblasts treated with transforming growth factor‐β, both of which were significantly higher than each control. In conclusion, we speculate that HB‐EGF plays a pro‐inflammatory role in the active skin and lung lesions of SSc. 相似文献
169.
170.
Misato Kashiba Mikiko Oizumi Masaru Suzuki Yoshimi Sawamura Kohei Nagashima Shinichi Yoshimura Yorihiro Yamamoto 《Journal of Clinical Biochemistry and Nutrition》2014,55(2):85-89
Coenzyme Q10 (CoQ10) is a key component of the mitochondrial electron transfer chain and is one of the most important cellular antioxidants. We previously reported that glycoprotein saposin B (SapB) binds CoQ10 in human cells. To elucidate the physiological role of SapB and its precursor, prosaposin (Psap), we prepared stable transfectants of HepG2 that overexpress wild-type human Psap (Wt-Tf). We also established a SapB domain mutated Psap (Mt-Tf) in which cysteine198 was replaced with serine to disrupt three dimensional protein structure by the loss of S-S bridging. Psap knockdown (KD) strains were also examined. Western blotting analysis confirmed overexpression or knockdown of Psap in these HepG2 cells. The cellular ratios of CoQ10 to free cholesterol (FC) significantly decreased in the order of Wt-Tf>parental>Mt-Tf>KD. Additionally, the ratios of CoQ10/FC in mitochondrial fractions decreased in the order of Wt-Tf>parental>KD. These data indicate that Psap and/or SapB regulate CoQ10 levels in HepG2 cells, especially in their mitochondria. 相似文献