全文获取类型
收费全文 | 4359篇 |
免费 | 198篇 |
国内免费 | 27篇 |
专业分类
耳鼻咽喉 | 56篇 |
儿科学 | 56篇 |
妇产科学 | 52篇 |
基础医学 | 557篇 |
口腔科学 | 128篇 |
临床医学 | 322篇 |
内科学 | 1256篇 |
皮肤病学 | 137篇 |
神经病学 | 339篇 |
特种医学 | 130篇 |
外科学 | 651篇 |
综合类 | 9篇 |
一般理论 | 1篇 |
预防医学 | 113篇 |
眼科学 | 125篇 |
药学 | 242篇 |
中国医学 | 4篇 |
肿瘤学 | 406篇 |
出版年
2022年 | 26篇 |
2021年 | 78篇 |
2020年 | 36篇 |
2019年 | 49篇 |
2018年 | 57篇 |
2017年 | 41篇 |
2016年 | 69篇 |
2015年 | 52篇 |
2014年 | 80篇 |
2013年 | 113篇 |
2012年 | 192篇 |
2011年 | 217篇 |
2010年 | 127篇 |
2009年 | 97篇 |
2008年 | 170篇 |
2007年 | 240篇 |
2006年 | 212篇 |
2005年 | 247篇 |
2004年 | 216篇 |
2003年 | 215篇 |
2002年 | 230篇 |
2001年 | 143篇 |
2000年 | 137篇 |
1999年 | 131篇 |
1998年 | 63篇 |
1997年 | 50篇 |
1996年 | 43篇 |
1995年 | 28篇 |
1994年 | 23篇 |
1993年 | 30篇 |
1992年 | 75篇 |
1991年 | 67篇 |
1990年 | 73篇 |
1989年 | 81篇 |
1988年 | 88篇 |
1987年 | 71篇 |
1986年 | 84篇 |
1985年 | 77篇 |
1984年 | 37篇 |
1983年 | 36篇 |
1982年 | 23篇 |
1979年 | 55篇 |
1978年 | 32篇 |
1977年 | 41篇 |
1976年 | 24篇 |
1974年 | 33篇 |
1972年 | 26篇 |
1971年 | 27篇 |
1970年 | 28篇 |
1969年 | 26篇 |
排序方式: 共有4584条查询结果,搜索用时 15 毫秒
81.
82.
83.
Colonoscopy has been shown to reduce the risk of colon cancer by enabling the removal of precancerous lesions. Although cold snare and hot snare polypectomy have similar retrieval rates and complete resection rates, rates of delayed bleeding tend to be lower with cold snare polypectomy than with hot snare polypectomy, especially for patients taking antithrombotic agents. However, among cold snares there may be differences in terms of the completeness of polyp excision, as complete removal appears more likely with thin‐wire dedicated cold snares compared to the traditional, thick‐wire cold snares. Cold snare polypectomy may be especially well suited for use in patients taking antithrombotic agents, due to its minimal risk of delayed bleeding. Histological analyses suggest that cold snare polypectomy causes less damage to blood vessels in the submucosal layers, which results in a reduced incidence of hemorrhage compared to hot snare polypectomy. However, cold snare removal of small polyps may result in fragmentation of small specimens during collection and concerns as to whether the resection is complete. An endoscopy biomarker of effective cold snare polypectomy technique is needed to ensure complete removal of non‐pedunculated colorectal polyps ≤10 mm. Future uses of cold snare polypectomy may include piecemeal removal of sessile serrated adenoma/polyp lesions >10 mm. Currently, cold snare polypectomy should be considered a primary method for colorectal polyps of less than 10 mm, especially those in the 4‐ to 10‐mm range. 相似文献
84.
Self‐expanding metallic stent improves histopathological edema compared with transanal drainage tube for malignant colorectal obstruction 下载免费PDF全文
85.
Shunsuke Uno Yosuke Horiuchi Takae Uchida Akiko Yonaha Takanori Miyata Eiko Nagano Takao Kodama Naoki Hasegawa 《Journal of infection and chemotherapy》2018,24(10):849-851
Aggregatibacter actinomycetemcomitans is well-known as the pathogen of gingivitis or periodontitis, and discitis or vertebral osteomyelitis cases caused by this organism have rarely been reported. Ampicillin or amoxicillin has been used in the previously reported discitis cases; however, no cases have been reported that is treated with levofloxacin. We report the first published case we chose levofloxacin to treat. We failed to perform the susceptibility testing because of the poor growth and fastidious nature of the organism, and the result of susceptibility of amoxicillin was unclear. Levofloxacin, which A. actinomycetemcomitans is usually susceptible to, can be an effective alternative oral antimicrobial agent in such cases. 相似文献
86.
Hikaru Ito Kanako Nozaki Kenji Sakimura Manabu Abe Shigeto Yamawaki Hidenori Aizawa 《Neuropsychopharmacology》2021,46(2):442
The lateral habenula (LHb) attracts a growing interest as a regulator of monoaminergic activity which were frequently reported to be defective in depression. Here we found that chronic social defeat stress (CSDS) increased production of pro-inflammatory cytokines in LHb associated with mobilization of monocytes and remodeling of extracellular matrix by increased matrix metalloproteinase (MMP) activity. RNA-seq analysis identified proprotein convertase Pcsk5 as an upstream regulator of MMP activation, with upregulation in LHb neurons of mice with susceptibility to CSDS. PCSK5 facilitated motility of microglia in vitro by converting inactive pro-MMP14 and pro-MMP2 to their active forms, highlighting its role in mobilization of microglia and monocytes in neuroinflammation. Suppression of Pcsk5 expression via small interfering RNA (siRNA) ameliorated depressive-like behaviors and pathological mobilization of monocytes in mice with susceptibility to CSDS. PCSK5-MMPs signaling pathway could be a target for development of the antidepressants targeting the inflammatory response in specific brain regions implicated in depression.Subject terms: Cellular neuroscience, Gene expression analysis 相似文献
87.
88.
89.
90.
Horiuchi Y Droog EJ Henricson J Wikström T Lennquist S Sjöberg F 《Microvascular research》2004,67(2):192-196
Nonspecific vasodilatation during iontophoresis is an important confounding factor in experimental pharmacology. In this investigation, we studied the involvement of sensory nerves and histamine-related reactions in causing nonspecific vasodilatation in a model of anodal and cathodal iontophoresis of sodium chloride. Firstly, we applied a mixture of local anesthetic (EMLA) cream to confirm its suppressive effect on nonspecific vasodilatation and to measure its efficacy in three different dosages (duration: 1, 2, and 3 h). We then investigated the role of histamine in nonspecific vasodilatation by giving an oral antihistamine drug (cetirizine) to subjects who had and had not been given EMLA. We found substantial suppression of the nonspecific vasodilatation in all EMLA-treated groups (all dosages) compared with untreated controls (with suppression rates of 60-65%). Dosage had no significant effect. A further suppression of nonspecific vasodilatation was seen after oral cetirizine during anodal and cathodal iontophoresis in both EMLA-treated and untreated groups. The antihistamine effect was most pronounced during anodal iontophoresis. These results suggest a histaminergic increase in perfusion that may be independent of neurogenic mechanisms and depend on polarity (anode or cathode). Local nerve blocks (EMLA) together with cetirizine may therefore be used to reduce nonspecific vasodilatation in both anodal and cathodal iontophoresis. 相似文献