全文获取类型
收费全文 | 5605篇 |
免费 | 235篇 |
国内免费 | 49篇 |
专业分类
耳鼻咽喉 | 26篇 |
儿科学 | 51篇 |
妇产科学 | 168篇 |
基础医学 | 650篇 |
口腔科学 | 90篇 |
临床医学 | 373篇 |
内科学 | 1589篇 |
皮肤病学 | 115篇 |
神经病学 | 403篇 |
特种医学 | 315篇 |
外科学 | 851篇 |
综合类 | 21篇 |
预防医学 | 108篇 |
眼科学 | 79篇 |
药学 | 324篇 |
中国医学 | 25篇 |
肿瘤学 | 701篇 |
出版年
2023年 | 22篇 |
2022年 | 45篇 |
2021年 | 104篇 |
2020年 | 53篇 |
2019年 | 74篇 |
2018年 | 134篇 |
2017年 | 97篇 |
2016年 | 118篇 |
2015年 | 125篇 |
2014年 | 152篇 |
2013年 | 239篇 |
2012年 | 332篇 |
2011年 | 363篇 |
2010年 | 231篇 |
2009年 | 188篇 |
2008年 | 343篇 |
2007年 | 384篇 |
2006年 | 366篇 |
2005年 | 372篇 |
2004年 | 405篇 |
2003年 | 369篇 |
2002年 | 342篇 |
2001年 | 118篇 |
2000年 | 105篇 |
1999年 | 93篇 |
1998年 | 91篇 |
1997年 | 59篇 |
1996年 | 75篇 |
1995年 | 46篇 |
1994年 | 39篇 |
1993年 | 43篇 |
1992年 | 45篇 |
1991年 | 37篇 |
1990年 | 35篇 |
1989年 | 30篇 |
1988年 | 27篇 |
1987年 | 33篇 |
1986年 | 25篇 |
1985年 | 25篇 |
1984年 | 20篇 |
1983年 | 18篇 |
1982年 | 10篇 |
1981年 | 11篇 |
1980年 | 5篇 |
1978年 | 11篇 |
1977年 | 4篇 |
1975年 | 3篇 |
1973年 | 3篇 |
1969年 | 3篇 |
1968年 | 3篇 |
排序方式: 共有5889条查询结果,搜索用时 453 毫秒
101.
102.
Masami Kosuge Kazuo Kimura Toshiyuki Ishikawa Tomoaki Shimizu Takeshi Takamura Kengo Tsukahara Yoshio Tahara Naoki Nozawa Eri Furukawa Osamu Tochikubo Mitsugi Sugiyama Satoshi Umemura 《Circulation journal》2004,68(6):526-531
BACKGROUND: The clinical significance of the white blood cell (WBC) count on admission in relation to the duration of ischemia in acute myocardial infarction (AMI) remains unclear. METHODS AND RESULTS: The relationship of the WBC count on admission to myocardial reperfusion was examined in 135 patients with recanalization of an anterior AMI within 6 h of symptom onset. Patients were classified according to the WBC count on admission: Group L (n=75), WBC count <12,000 cells/mm(3) and group H (n=60), WBC count >or=12,000 cells/mm(3). Peak creatine kinase (CK) was higher and impaired myocardial reperfusion, defined as a myocardial blush grade of 0/1, was more frequent in group H than in group L. Among the patients in group H, those with early (3 h) recanalization; however, peak CK and the incidence of impaired myocardial reperfusion were similar in these subgroups of patients. Multivariate analysis showed that WBC count >or=12,000 cells/mm(3) on admission was an independent predictor of impaired myocardial reperfusion in patients with early recanalization (odds ratio 7.9, p=0.04), but not in those with late recanalization. CONCLUSIONS: A higher WBC count may be associated with progression of myocardial damage after recanalization in patients with early recanalization of an anterior AMI. 相似文献
103.
Janssen R Sato H Grutters JC Ruven HJ du Bois RM Matsuura R Yamazaki M Kunimaru S Izumi T Welsh KI Nagai S van den Bosch JM 《American journal of respiratory and critical care medicine》2004,170(11):1185-1187
CC10 (CC16, uteroglobin) is a pulmonary protein postulated to play a counter regulatory role in sarcoidosis pathogenesis. The adenine38guanine (A38G) polymorphism of the encoding CC10 gene (SCGB1A1) is functional. Recently, an association between the low CC10 producing 38A allele and sarcoidosis susceptibility has been reported in Japanese patients from Hokkaido. The aim of the present study was to confirm this association in a clinically well characterized population of Dutch white and Kyoto Japanese patients with sarcoidosis and control subjects. No difference in genotype or allele frequency was found between patients with sarcoidosis and control subjects in either ethnic population. Remarkably, however, a significant difference was found between the control subjects from Kyoto and Hokkaido, but not between the Japanese groups of patients with sarcoidosis. Furthermore, review of previously published A38G genotyping results showed a consistent difference in CC10 A38G allele frequencies between whites and Japanese subjects. We conclude that the CC10 A38G polymorphism does not influence sarcoidosis susceptibility in Dutch whites or in Japanese subjects from Kyoto. This stresses the importance of studying the influence of polymorphisms on disease susceptibility in multiple ethnically and geographically distinct disease and control populations before reaching conclusions. 相似文献
104.
Tomomi Sato Masaru Usui Shigeki Maetani Yutaka Tamura 《Journal of infection and chemotherapy》2018,24(7):588-591
The aim of the present study was to determine and compare the prevalence of methicillin-resistant Staphylococcus aureus (MRSA) and their molecular characteristics among veterinary staff in Sapporo in 2008 and 2016. We isolated MRSA from veterinarians (Vet; n = 91), veterinary technicians (VT; n = 113), and other staff members (n = 24) from 45 small animal hospitals (animal hospitals), as well as from surface swabs (n = 123) obtained from 37 animal hospitals, in 2016. MRSA was observed in 14 Vets (15%), 7 VTs (6%), 2 other staff members (8%), and 6 environmental samples (5%). The prevalence of MRSA among veterinary staff tended to decrease, in comparison to 2008. All the MRSA isolates were classified as CC5/SCCmecII, which is commonly observed in medical settings in Japan. Upon performing pulse-field gel electrophoresis, with SmaI and EagI, and clfB sequence typing, it was observed that 16 of the MRSA isolates from 2016 were highly similar to those obtained in 2008. This suggests that some MRSA isolates persisted throughout 8 years, although their origins remain unclear. The continuation of education and monitoring of MRSA is necessary for the prevention and control of infection in these settings. 相似文献
105.
Tomoo Yamazaki Satoru Joshita Eriko Kasuga Kazuki Horiuchi Ayumi Sugiura Naoyuki Fujimori Michiharu Komatsu Takeji Umemura Akihiro Matsumoto Eiji Tanaka 《Journal of infection and chemotherapy》2018,24(5):393-397
A 73-year-old woman was admitted with consciousness disturbance following a fever. Abdominal computed tomography revealed a large liver abscess with which the presence of Desulfovibrio desulfuricans and Escherichia coli was confirmed by thorough blood and abscess content culture. Empiric meropenem treatment was switched to cefoperazone/sulbactam, followed by ampicillin/sulbactam based on susceptibility testing. Desulfovibrio desulfuricans is a common bacterium that rarely causes liver abscess and may be overlooked during co-infection due to overgrowth of the accompanying bacteria. Clinicians should bear Desulfovibrio desulfuricans in mind and select the appropriate antibiotics according to susceptibility testing when anaerobic bacteria are detected in a liver abscess. 相似文献
106.
Sakamoto Kazumasa Ito Kiyoaki Yotsuyanagi Hiroshi Yatsuhashi Hiroshi Tanaka Yasuhito Hige Shuhei Takikawa Yasuhiro Ueno Yoshiyuki Yamamoto Kazuhide Imazeki Fumio Inoue Jun Kurosaki Masayuki Umemura Takeji Toyoda Hidenori Mita Eiji Michitaka Kojiro Maeshiro Tatsuji Yamada Norie Suetsugu Atsushi Kawanaka Miwa Seko Yuya Matsuura Kentaro Okumura Akinori Fukuzawa Yoshitaka Sugiyama Masaya Mizokami Masashi Yoneda Masashi 《Journal of gastroenterology》2022,57(12):971-980
Journal of Gastroenterology - Hepatitis B virus (HBV) is one of the most prevalent chronic viral infections that causes chronic hepatitis B (CHB). In Japan, genotypes B and C account for most of... 相似文献
107.
Ikoma A Namai K Saito T Kawano T Saito T Kasono K Tamemoto H Yamada S Kawakami M Ishikawa SE 《Endocrine journal》2004,51(5):463-466
The adrenal gland is one of the organs which tuberculosis infects. In most clinical settings bilateral adrenal tuberculosis has been clarified after adrenal insufficiency is overt. On the contrary, active adrenal tuberculosis is rarely detected during the survey of infectious disease. A 68-year-old man was admitted because of intermittent fever. The fever had continued for the last 3 months. The intermittent fever was accompanied with leukocytosis and elevation of C-reactive protein. Serum soluble interleukin-2 receptor was 1920 U/ml, and beta2-microglobulin was 4.0 mg/l. Bacterial cultures of blood, sputa, urine, bone marrow and cerebrospinal fluid did not show any particular bacteria. Mycobacterium tuberculosis was negative in culture of sputa, and there was no tuberculin reaction. Plasma ACTH and serum cortisol were 18.5 pmol/l and 527.0 nmol/l, respectively. Abdominal CT scan showed right adrenal mass with a size of 28 x 20 mm, which was low density and had a well-encapsulated homogenous appearance. After the adrenalectomy, histology verified active adrenal tuberculosis. The intermittent fever disappeared, and white blood cells and C-reactive protein normalized. These findings indicate an atypical, rare case of unilateral, active adrenal tuberculosis closely linked to intermittent fever, and without any other organ involvement. 相似文献
108.
Orii T Ohkohchi N Kikuchi H Sekiguchi S Kawagishi N Tsukamoto S Satomi S 《Hepato-gastroenterology》2003,50(50):530-531
A 76-year-old male patient with jaundice was diagnosed as having hepatic hilar cholangiocarcinoma. The patient underwent percutaneous transhepatic biliary drainage of the left and the right intrahepatic bile duct. He could not have a percutaneous transhepatic endoprosthesis placed because it was impossible to pass the guidewire through the stenotic portion of the lesion. The patient was operated, but the tumor was considered to be unresectable. Along the intrahepatic routes formed by the preexisting two percutaneous transhepatic biliary drainage tubes, silicon tubes were inserted. Through the lumen of a long jejunal limb, Roux-en-Y, the tubes with five to six side holes were passed in the distal direction and drawn out from the lumen of the jejunal limb and passed through the abdominal wall to outside. The tubes were occluded and buried in the subcutaneous space after a few clamping tests. He died of liver failure in his house four months after the operation without any symptoms of jaundice, fever or of obstruction of the tubes. 相似文献
109.
Hiroyuki Orita Takao Shimanuki Manabu Fukasawa Hiromasa Abe Setsuo Kuraoka Shigeki Hirooka Masahiko Washio 《Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy》1991,5(4):727-732
Cardiac reperfusion injury after heart transplantation or cardiopulmonary bypass has been difficult to control due to the variable degree of myocardial damage with respect to the length of ischemia and the complexity of the surgical procedure. Here, we evaluated the myocardial metabolic and functional recovery of hearts infused with a nicorandil vasodilator-magnesium (Mg) solution just prior to reperfusion (terminal cardioplegia). Donor hearts (20 dogs) were removed and immersed in a 4 degrees C water bath containing 20 mEq/l KCL-5% glucose for 6 hours, and then were transplanted to recipient dogs. Orthotopically transplanted dog hearts were either reperfused without any further treatment or received a terminal cardioplegic solution containing 8 mg/l nicorandil, 30 mEq/l Mg, and 50 g/l glucose, which was infused at a pressure of 75 cm H2O for 2 minutes. During the reperfusion period, myocardial tissue PCO2 (t-PCO2) and calcium ion (t-Ca) were continuously monitored by an ISFET (ion-sensitive field effect transistor) sensor. Myocardial oxygen consumption and lactate flux were calculated/monitored at 5, 10, 20 and 40 minutes of reperfusion. Thereafter, myocardial function was evaluated at 45 minutes of reperfusion using LVSWI. Just after reperfusion, the treatment group (group B, n = 10) had a significantly greater coronary flow than the control group (Group A, n = 10, 35.0 +/- 10.1; group B, 47.4 +/- 8.5 ml/100 g/min, p less than 0.025).(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献