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91.
Hsiao KY Lin LC Chou MH Chen CC Lee HC Foo NP Shiao CJ Chen IC Hsiao CT Chen KH 《Injury》2012,43(9):1575-1579
BackgroundIn this study, we attempted to identify differences in the outcomes of patients with severe trauma who were directly transported to our hospital, and those who were stabilised initially at other hospitals in south-central Taiwan.MethodsWe performed a prospective observational study to review the records of 231 patients with major trauma (Injury Severity Scores (ISS) >15) who visited our hospital's emergency department from January 2010 to December 2010. Among these patients, 75 were referred from other hospitals. Logistic regression was performed to assess the effects of transfer on mortality.ResultsPatients in the transfer group had a shorter interval between trauma and admission to the first hospital (25.3 min vs. 28.1 min), and the average interval between the two hospital arrivals was 138.3 min. Transfer from another hospital was not significantly correlated with mortality in this study (odds ratio: 1.124, 95% confidence interval: 0.276–4.578).ConclusionIn trauma patients with ISS > 15, there is no difference in mortality between those transferred from another hospital after initial stabilisation and those who visited our emergency department directly. 相似文献
92.
紫外分光光度法测定复方酮康唑软膏中酮康唑和氧氟沙星的含量 总被引:4,自引:0,他引:4
目的:建立复方酮康唑软膏的含量测定方法。方法:用双波长分光光度法测定酮康唑的含量,用单波长法测定氧氟沙星的含量。结果:两被测组分的平均回收率和相对标准偏差分别为酮康唑100.33%和0.32%;氧氟沙星100.85%和0.27%。结论:方法简便、准确,可用于复方酮康唑软膏的质量控制。 相似文献
93.
E. LACASSIE A. DELMAS C. MEUNIER D. SY Y. TRUDELLE 《Chemical biology & drug design》1996,48(3):249-258
An amphipathic polypeptide, Pn, with a tandemly repeated LKELPEKL sequence including a proline every eight residues, as well as a series of shorter peptides having the same sequence, P2, P3, P4, P5 and P6, were synthesized. Their conformation in aqueous solution was mainly studied by CD. At low temperature, these peptides and polypeptide are completely unordered and undergo a reversible transition leading to a partly α-helical structure upon heating. Such behavior has been demonstrated for a few proteins by other authors and has been called cold-denaturation. The transition temperature of the polypeptide is close to 20 ° C. The conformational change does not depend on concentration, indicating a monomolecular process. The high-temperature structure seems to be compact as for globular proteins. A model of folded structure is proposed from experimental data and from molecular modelling studies. © Munksgaard 1996. 相似文献
94.
The elbow: MR features of nerve disorders 总被引:3,自引:0,他引:3
95.
Alternating poly(Glu-Leu) was synthesized by the condensation of the corresponding dipeptide p-nitrophenyl ester at high concentration. It exhibits a random coil structure in pure water at neutral pH. Addition of monovalent cations, such as NH+4 to a final 0.1 M solution, induces a transition to a water soluble β-structure. The salt effect is quite selective since no transition was observed with Li+, Na+ or Cs+ ions. Addition of 0.5 equiv. of calcium, cobalt or manganese chlorides per glutamyl residue induces similar coil to β-sheet transitions. No polymer precipitation was observed at these very low salt concentrations. Addition of 0.5 equiv. of Cu2+ or 0.15 equiv. of Fe3+ induces a coil to α-helix transition. Molecular modeling has been used to understand tentatively the main factors controlling the different conformations observed with the various metal ions. © Munksgaard 1997. 相似文献
96.
Two cases of cystic pulmonary hamartoma are reported with the clinical, roentgenographic and histopathologic findings. Both patients were asymptomatic, and the lesions were discovered on routine chest roentgenography. Physical examination and laboratory data revealed no significant abnormal findings, but CT scans of the chest showed cystic change in both lesions. The histopathologic pictures of the lesions were characterized by a composition of glandular bronchiolar structures lined with ciliated cuboid epithelium and fibrous connective tissue. One case demonstrated interlacing, communicating bands and whorls of smooth spindle muscle cells with elongated nuclei and rounded blunt ends. Neither the epithelial, nor muscular fibrous tissue elements exhibited any degree of anaplasia. The two patients were followed up for 10 months and 3 years, respectively. They both showed no signs of recurrence or distant metastasis. 相似文献
97.
6-取代苯基哒嗪的3位γ-氨基丁酸衍生物的合成及抗惊活性 总被引:1,自引:0,他引:1
GABA的合成类似物是开发新型抗惊剂和抗癫痫药物的新领域。由芳香醛与吗啉、氰化钾反应形成的α-芳基-α-(4-吗啉)乙腈,可对α,β-不饱和腈或酯进行1,4-加成,生成1,4-酮酸型化合物。此物与肼缩合,再经芳构化即得6-芳基-3(2H)哒嗪酮。后者再经氯化后。与GABA缩合,制备3-(N-GABA)-6-芳基哒嗪类及其分子内脱水产物3-(N-丁内酰胺)-6-芳基哒嗪类化合物。本文应用此法合成了17个上述苯代哒嗪的GABA衍生物,并初步测验了它们的抗惊(MES)活性。活性最强的是3-(N-GABA)-6-(2′,4′-二氯苯基)哒嗪(ED50=21.05mg/kg)。 相似文献
98.
99.
Andrew KC Lam Ken KH Cheng Rex K Lam Christina FC Lau SY Yau 《Clinical & experimental optometry》1996,79(4):167-172
Myopic crescent, refractive error and axial length were previously investigated in Hong Kong Chinese subjects. The myopic crescent was found to correlate with axial length and myopic refraction. In this study, three groups of Hong Kong Chinese with different degrees of myopia were assessed for optic disc ovalness, refractive error and axial length. The axial length was significantly correlated with the degree of myopia, indicating that the myopia was axial in nature. The regression line shows that 0.44 mm of axial elongation would give about one dioptre of increase in myopia. The elliptical ratio of the optic disc was defined as the maximal disc diameter divided by the minimal disc diameter. All three groups showed an oval disc with vertical axis greater and an increased ovalness for the high myopic group with an elliptical ratio from 1.11 in low myopia to 1.29 in high myopia. There is a small amount (about four degrees) of temporal rotation of this vertical oval orientation, which is independent of the amount of myopia. This result shows an association between axial elongation of the globe and optic disc ovalness, in addition to the previously described temporal myopic crescent. Therefore, in myopic subjects, a vertically oval disc may be associated with a myopic refraction rather than glaucoma. 相似文献
100.