全文获取类型
收费全文 | 296648篇 |
免费 | 17347篇 |
国内免费 | 414篇 |
专业分类
耳鼻咽喉 | 4210篇 |
儿科学 | 10299篇 |
妇产科学 | 10250篇 |
基础医学 | 45031篇 |
口腔科学 | 7500篇 |
临床医学 | 24200篇 |
内科学 | 56080篇 |
皮肤病学 | 6312篇 |
神经病学 | 21004篇 |
特种医学 | 11622篇 |
外国民族医学 | 43篇 |
外科学 | 46718篇 |
综合类 | 7792篇 |
现状与发展 | 1篇 |
一般理论 | 160篇 |
预防医学 | 19939篇 |
眼科学 | 6944篇 |
药学 | 20891篇 |
中国医学 | 787篇 |
肿瘤学 | 14626篇 |
出版年
2018年 | 3616篇 |
2017年 | 2655篇 |
2016年 | 3071篇 |
2015年 | 3491篇 |
2014年 | 4580篇 |
2013年 | 7211篇 |
2012年 | 9067篇 |
2011年 | 9449篇 |
2010年 | 6128篇 |
2009年 | 5558篇 |
2008年 | 8674篇 |
2007年 | 9524篇 |
2006年 | 9360篇 |
2005年 | 8959篇 |
2004年 | 8662篇 |
2003年 | 8166篇 |
2002年 | 7766篇 |
2001年 | 13329篇 |
2000年 | 13657篇 |
1999年 | 11426篇 |
1998年 | 3026篇 |
1997年 | 2794篇 |
1996年 | 2634篇 |
1995年 | 2545篇 |
1994年 | 2345篇 |
1992年 | 8322篇 |
1991年 | 8456篇 |
1990年 | 8272篇 |
1989年 | 8081篇 |
1988年 | 7324篇 |
1987年 | 7085篇 |
1986年 | 6735篇 |
1985年 | 6538篇 |
1984年 | 4782篇 |
1983年 | 4145篇 |
1982年 | 2493篇 |
1979年 | 4449篇 |
1978年 | 3253篇 |
1977年 | 2747篇 |
1976年 | 2520篇 |
1975年 | 2851篇 |
1974年 | 3376篇 |
1973年 | 3386篇 |
1972年 | 3142篇 |
1971年 | 2966篇 |
1970年 | 2849篇 |
1969年 | 2590篇 |
1968年 | 2546篇 |
1967年 | 2384篇 |
1966年 | 2278篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
91.
A. Giacometti O. Cirioni G. Greganti A. Fineo R. Ghiselli M. Del Prete F. Mocchegiani B. Fileni F. Caselli E. Petrelli V. Saba G. Scalise 《European journal of clinical microbiology & infectious diseases》2002,21(7):553-556
The in vitro activities of povidone iodine, potassium peroxymonosulfate, and dimethyldidecylammonium chloride were investigated
against 379 nosocomial isolates of Staphylococcus aureus and Pseudomonas aeruginosa responsible for surgical wound infections in patients operated on between July 1995 and June 2001. Overall, the isolates
were inhibited by the antiseptics at concentrations below those used routinely. In spite of increasing resistance to the various
antibiotics used to treat surgical wound infections, no significant variation in the susceptibility to antiseptics was demonstrated
during this 6-year study.
Electronic Publication 相似文献
92.
A. O. Azghani J. W. Baker S. Shetty E. J. Miller G. J. Bhat 《Inflammation research》2002,51(10):506-510
OBJECTIVE AND DESIGN: Bacterial products as well as the host airway inflammatory responses contribute to the pathogenesis of Pseudomonas infections. We sought to determine if Pseudomonas elastase (PE) induces mitogen-activated protein (MAP) kinase activity in association with interleukin-8 (IL-8) production by alveolar epithelial cells. METHODS: We utilized Western blot analysis to detect phosphorylation of signaling intermediates and ELISA was used to measure IL-8 production. RESULTS: We found that PE induces phosphorylation of the extracellular signal-regulated (ERK1/2) proteins of the MAPK pathway in A549 epithelial cells. Similar results were obtained using primary cultures of rabbit alveolar type II epithelial cells. PE also enhanced IL-8 production, which was abolished in the presence of the ERK activation inhibitor U0126. CONCLUSIONS: We conclude that PE activates the ERK1/2 arm of the MAPK pathway and that activation of this pathway results in enhanced IL-8 production. The results demonstrate that PE may augment pulmonary inflammation via cellular signaling that regulates expression of IL-8. 相似文献
93.
94.
Paul Steinbok Ken Poskitt D. Douglas Cochrane O. Olof Flodmark 《Child's nervous system》1991,7(1):16-20
Enhanced and non-enhanced computed tomography (CT) brain scans were performed within 72 h of surgery on 21 children in whom brain tumors had been resected totally or subtotally, and scans were repeated at varying intervals thereafter. Biopsies of the resection margins were performed in 12 patients at the end of the surgical procedure. The immediate CT scan showed enhancement in the resection margin in 13 of the 21 patients and in 9 of the 13, the enhancement disappeared on follow-up scans. There was discordance between the results of immediate CT scan examination and the biopsies of the resection margins in 7 of the 12 cases. The advantages and disadvantages of an immediate postoperative scan versus a more delayed CT scan are discussed. 相似文献
95.
I A Bochkov O D Trofimova O S Darbeeva R S Cherkasskaia M S Shevchuk 《Laboratornoe delo》1989,(6):43-47
Formulae for the calculation of the count of microorganisms isolated from natural bacterial biocenoses of a child's body have been derived. The authors suggest a variant of simplified drip method for the computation of microorganism colonies in solid media. The described method helps cut down the nutrient media consumption at least 3-fold and is time-saving. 相似文献
96.
The aqueous, organic, and volatile oil extracts of leaves of Eugenia uniflora Linn. Family Myrtaceae were investigated for antibacterial properties using agar dilution techniques. The aqueous extract was the most active against the organisms compared to the organic and volatile oil extracts. The extracts were found to inhibit Gram positive Staphylococcus aureus and Bacillus subtilis and Gram negative Escherichia coli and Shigella dysentcriae. Pseudomonas aeruginosa, Klebsiella pneumoniac, and Salmonella typhi were not inhibited. 相似文献
97.
K Takeuchi O Furukawa H Tanaka H Nishiwaki S Okabe 《Japanese journal of pharmacology》1987,44(2):163-170
The effects of hemorrhagic shock (HE) on duodenal pH, acid-neutralizing capacity and mucosal tolerance to acid were investigated in anesthetized rats, and they were compared with those of indomethacin. HE was performed by bleeding from the carotid artery to reduce arterial blood pressure to about 55 mmHg (3 ml of bleeding per 200 g of body weight), and indomethacin was given s.c. in a dose of 5 mg/kg. Duodenal pH was determined in the outflow from the proximal duodenum (1.7 cm) which was perfused with 10(-4) M HCl, and acid-neutralizing capacity was measured by back-titration of the perfusate to pH 4.0 with 10 mM HCl. Under these conditions, duodenal pH was kept at around 6.0 as the result of neutralization in the loop (approximately 8 microEq/hr). Both HE and indomethacin significantly decreased the pH and acid-neutralizing capacity. Administration of 16,16-dimethyl prostaglandin E2 (16-dmPGE2: 30 micrograms/kg, s.c.) significantly increased both pH and acid-neutralizing capacity in normal and indomethacin-treated rats, but failed to affect these parameters in rats under HE conditions. When the duodenal loop was perfused with 50 mM HCl for 1.5 hr, both HE and indomethacin induced extensive damage in the mucosa. Pretreatment with 16-dmPGE2 significantly reduced the formation of duodenal lesions induced by indomethacin but not by HE. These results suggest that HE as well as indomethacin impaired duodenal acid-neutralizing capacity to reduce the tolerance to acid of the mucosa. The deleterious effects of HE on the mucosa may be mainly due to a decreased mucosal blood flow, but not due to a deficiency of endogenous prostaglandins. 相似文献
98.
Techniques of ankle arthroscopy 总被引:1,自引:0,他引:1
R O Lundeen 《The Journal of foot surgery》1987,26(1):22-25
Although arthroscopic instrumentation varies widely, the technique for use is quite similar. Surgeon preferences vary but most arthroscopists agree that it is technique that makes the procedure. Discussed in this presentation is the author's method for preparing the patient for arthroscopic surgery, as well as techniques for using the arthroscope, hand instruments, and power instrumentation. 相似文献
99.
Inhibition of vessel allograft rejection by endothelial removal. Morphologic and ultrastructural changes. 总被引:1,自引:1,他引:0 下载免费PDF全文
M A Galumbeck F P Sanfilippo P O Hagen A V Seaber J R Urbaniak 《Annals of surgery》1987,206(6):757-764
The vascular endothelium plays an important and complex role in vascular allograft rejection. Antigens expressed by the endothelium can act to promote and be the target of rejection reactions, which often lead to thrombosis and ischemic necrosis of the allograft. In this study, segments of femoral artery and femoral vein with or without endothelium were grafted between allogenic or autologous control rats. Immunocompetent Lewis (RT1(1] recipient rats were randomly selected for groups (N = 14 for each) receiving the following: ACI- (RT1a) allografts with intact endothelium, allografts with endothelium removed before operation, autografts with endothelium, and autografts with endothelium removed. Rejection was assessed by graft patency as well as morphologic and ultrastructural changes. At 5 days, the allografts with intact endothelium were totally occluded, whereas allografts without endothelium remained patent, as did autologous control grafts with or without endothelium. Two additional groups (N = 14 each) receiving the de-endothelialized allografts or autografts were examined at 120 days after operation, revealing that grafts in both groups were still patent and had been re-endothelialized. These findings indicate that physical removal of vascular endothelium may depress vessel allograft rejection without immunosuppressive therapy. 相似文献
100.