全文获取类型
收费全文 | 8112篇 |
免费 | 604篇 |
国内免费 | 35篇 |
专业分类
耳鼻咽喉 | 76篇 |
儿科学 | 395篇 |
妇产科学 | 189篇 |
基础医学 | 1000篇 |
口腔科学 | 231篇 |
临床医学 | 1104篇 |
内科学 | 1406篇 |
皮肤病学 | 106篇 |
神经病学 | 707篇 |
特种医学 | 257篇 |
外国民族医学 | 3篇 |
外科学 | 807篇 |
综合类 | 110篇 |
一般理论 | 13篇 |
预防医学 | 1185篇 |
眼科学 | 91篇 |
药学 | 516篇 |
中国医学 | 16篇 |
肿瘤学 | 539篇 |
出版年
2023年 | 73篇 |
2022年 | 126篇 |
2021年 | 281篇 |
2020年 | 157篇 |
2019年 | 262篇 |
2018年 | 247篇 |
2017年 | 198篇 |
2016年 | 186篇 |
2015年 | 201篇 |
2014年 | 315篇 |
2013年 | 417篇 |
2012年 | 605篇 |
2011年 | 600篇 |
2010年 | 273篇 |
2009年 | 280篇 |
2008年 | 430篇 |
2007年 | 478篇 |
2006年 | 454篇 |
2005年 | 456篇 |
2004年 | 385篇 |
2003年 | 328篇 |
2002年 | 269篇 |
2001年 | 112篇 |
2000年 | 113篇 |
1999年 | 92篇 |
1998年 | 79篇 |
1997年 | 57篇 |
1996年 | 32篇 |
1995年 | 51篇 |
1994年 | 31篇 |
1993年 | 32篇 |
1992年 | 70篇 |
1991年 | 54篇 |
1990年 | 58篇 |
1989年 | 78篇 |
1988年 | 58篇 |
1987年 | 67篇 |
1986年 | 67篇 |
1985年 | 52篇 |
1984年 | 37篇 |
1983年 | 32篇 |
1981年 | 28篇 |
1980年 | 29篇 |
1979年 | 44篇 |
1978年 | 36篇 |
1977年 | 51篇 |
1976年 | 30篇 |
1975年 | 35篇 |
1972年 | 37篇 |
1970年 | 34篇 |
排序方式: 共有8751条查询结果,搜索用时 11 毫秒
81.
82.
83.
84.
85.
An acquired G-CSF receptor mutation results in increased proliferation of CMML cells from a patient with severe congenital neutropenia. 总被引:1,自引:0,他引:1
M Germeshausen H Schulze C Kratz L Wilkens R Repp K Shannon K Welte M Ballmaier 《Leukemia》2005,19(4):611-617
Severe congenital neutropenia (CN) is characterized by a maturation arrest of myelopoiesis at the promyelocyte stage. Treatment with pharmacological doses of recombinant human granulocyte colony-stimulating factor (rh-G-CSF) stimulates neutrophil production and decreases the risk of major infectious complications. However, approximately 15% of CN patients develop myeloid malignancies that have been associated with somatic mutations in the G-CSF receptor (G-CSFR) and RAS genes as well as with acquired monosomy 7. We report a CN patient with chronic myelomonocytic leukemia (CMML) who never received rh-G-CSF. Molecular analysis demonstrated a somatic G-CSFR mutation (C2390T), which led to expression of a truncated G-CSFR protein in the CMML. Normal G-CSFR expression was unexpectedly absent in primary and cultured CMML. In addition, CMML cells showed monosomy 7 and an oncogenic NRAS mutation. In vitro culture revealed a G-CSF-dependent proliferation of CMML cells, which subsequently differentiated along the monocytic/macrophage lineage. Our results provide direct evidence for the in vivo expression of a truncated G-CSFR in leukemic cells, which emerged in the absence of rh-G-CSF treatment and transduces proliferative signals. 相似文献
86.
Elizabeth Tan-Chiu Greg Yothers Edward Romond Charles E Geyer Michael Ewer Deborah Keefe Richard P Shannon Sandra M Swain Ann Brown Louis Fehrenbacher Victor G Vogel Thomas E Seay Priya Rastogi Eleftherios P Mamounas Norman Wolmark John Bryant 《Journal of clinical oncology》2005,23(31):7811-7819
PURPOSE: Trastuzumab is effective in treating human epidermal growth factor receptor 2 (HER2) -positive breast cancer, but it increases frequency of cardiac dysfunction (CD) when used with or after anthracyclines. PATIENTS AND METHODS: National Surgical Adjuvant Breast and Bowel Project trial B-31 compared doxorubicin and cyclophosphamide (AC) followed by paclitaxel with AC followed by paclitaxel plus 52 weeks of trastuzumab beginning concurrently with paclitaxel in patients with node-positive, HER2-positive breast cancer. Initiation of trastuzumab required normal post-AC left ventricular ejection fraction (LVEF) on multiple-gated acquisition scan. If symptoms suggestive of congestive heart failure (CHF) developed, source documents were blindly reviewed by an independent panel of cardiologists to determine whether criteria were met for a cardiac event (CE), which was defined as New York Heart Association class III or IV CHF or possible/probable cardiac death. Frequencies of CEs were compared between arms. RESULTS: Among patients with normal post-AC LVEF who began post-AC treatment, five of 814 control patients subsequently had confirmed CEs (four CHFs and one cardiac death) compared with 31 of 850 trastuzumab-treated patients (31 CHFs and no cardiac deaths). The difference in cumulative incidence at 3 years was 3.3% (4.1% for trastuzumab-treated patients minus 0.8% for control patients; 95% CI, 1.7% to 4.9%). Twenty-seven of the 31 patients in the trastuzumab arm have been followed for > or = 6 months after diagnosis of a CE; 26 were asymptomatic at last assessment, and 18 remained on cardiac medication. CHFs were more frequent in older patients and patients with marginal post-AC LVEF. Fourteen percent of patients discontinued trastuzumab because of asymptomatic decreases in LVEF; 4% discontinued trastuzumab because of symptomatic cardiotoxicity. CONCLUSION: Administering trastuzumab with paclitaxel after AC increases incidence of CHF and lesser CD. Potential cardiotoxicity should be carefully considered when discussing benefits and risks of this therapy. 相似文献
87.
88.
Luke Nyakarahuka Shannon Whitmer Jackson Kyondo Sophia Mulei Caitlin M. Cossaboom Carson T. Telford Alex Tumusiime Gloria Grace Akurut Dianah Namanya Kilama Kamugisha Jimmy Baluku Julius Lutwama Stephen Balinandi Trevor Shoemaker John D. Klena 《Emerging infectious diseases》2022,28(11):2326
Crimean-Congo hemorrhagic fever (CCHF) was detected in 2 refugees living in a refugee settlement in Kikuube district, Uganda. Investigations revealed a CCHF IgG seroprevalence of 71.3% (37/52) in goats within the refugee settlement. This finding highlights the need for a multisectoral approach to controlling CCHF in humans and animals in Uganda. 相似文献
89.
Amanda Reiff Metz Matthew Bauer Chelsey Epperly Ginger Stringer Kristen E. Marshall Lindsey Martin Webb Molly Hetherington-Rauth Shannon R. Matzinger Sarah Elizabeth Totten Emily A. Travanty Kristen M. Good Alexis Burakoff 《Emerging infectious diseases》2022,28(8):1551
A COVID-19 outbreak occurred among Cameron Peak Fire responders in Colorado, USA, during August 2020–January 2021. The Cameron Peak Fire was the largest recorded wildfire in Colorado history, lasting August–December 2020. At least 6,123 responders were involved, including 1,260 firefighters in 63 crews who mobilized to the fire camps. A total of 79 COVID-19 cases were identified among responders, and 273 close contacts were quarantined. State and local public health investigated the outbreak and coordinated with wildfire management teams to prevent disease spread. We performed whole-genome sequencing and applied social network analysis to visualize clusters and transmission dynamics. Phylogenetic analysis identified 8 lineages among sequenced specimens, implying multiple introductions. Social network analysis identified spread between and within crews. Strategies such as implementing symptom screening and testing of arriving responders, educating responders about overlapping symptoms of smoke inhalation and COVID-19, improving physical distancing of crews, and encouraging vaccinations are recommended. 相似文献
90.
Pamela T. Soliman David Iglesias Mark F. Munsell Michael Frumovitz Shannon N. Westin Alpa M. Nick Kathleen M. Schmeler Pedro T. Ramirez 《Gynecologic oncology》2013