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Mansour-Ghanaei F Taheri A Froutan H Ghofrani H Nasiri-Toosi M Bagherzadeh AH Farahvash MJ Mirmomen S Ebrahimi-Dariani N Farhangi E Pourrasouli Z 《World journal of gastroenterology : WJG》2006,12(7):1125-1128
AIM:To determine the efficacy and potential complica-tions of oral naltrexone used in the treatment of pruritusin cholestatic patients and to compare them with otherstudies.METHODS:Thirty-four enrolled cholestatic patientscomplaining of pruritus were studied.In the initial phase,pruritus scores during day and night were evaluated.Sub-sequently,patients were given a placebo for one weekfollowed by naltrexone for one week.In each therapeuticcourse(placebo or naltrexone)day and night pruritusscores were distinguished by a visual analogue scale(VAS)system and recorded in patients'questionnaires.RESULTS:Both naltrexone and placebo decreased VASscores significantly.Naltrexone was more effective thanplacebo in decreasing VAS scores.Both day and nightscores of pruritus decreased by half of the value priorto therapy in thirteen patients(38%).Daytime pruritusimproved completely in two patients(5.9%),but no im-provement in the nighttime values was observed in anypatient.Sixteen patients(47%)suffered from naltrexonecomplications,eleven(32%)of them were related to itswithdrawal.Complications were often mild.In the caseof withdrawal,the complication was transient(withinthe first 24-28 h of therapy)and self-limited.We had tocease the drug in two cases(5.9%)because of severewithdrawal symptoms. CONCLUSION:Naltrexone can be used in the treatmentof pruritus in cholestatic patients and is a safe drugshowing few,mild and self-limited complications. 相似文献
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Elahi E Shafaghati Y Asadi S Absalan F Goodarzi H Gharaii N Karimi-Nejad MH Shahram F Hughes AE 《Journal of bone and mineral metabolism》2007,25(3):159-164
Familial expansile osteolysis (FEO) is a rare disorder causing bone dysplasia. The clinical features of FEO include early-onset
hearing loss, tooth destruction, and progressive lytic expansion within limb bones causing pain, fracture, and deformity.
An 18-bp duplication in the first exon of the TNFRSF11A gene encoding RANK has been previously identified in four FEO pedigrees. Despite having the identical mutation, phenotypic
variations among affected individuals of the same and different pedigrees were noted. Another 18-bp duplication, one base
proximal to the duplication previously reported, was subsequently found in two unrelated FEO patients. Finally, mutations
overlapping with the mutations found in the FEO pedigrees have been found in ESH and early-onset PDB pedigrees. An Iranian
FEO pedigree that contains six affected individuals dispersed in three generations has previously been introduced; here, the
clinical features of the proband are reported in greater detail, and the genetic defect of the pedigree is presented. Direct
sequencing of the entire coding region and upstream and downstream noncoding regions of TNFRSF11A in her DNA revealed the same 18-bp duplication mutation as previously found in the four FEO pedigrees. Additionally, eight
sequence variations as compared to the TNFRSF11A reference sequence were identified, and a haplotype linked to the mutation based on these variations was defined. Although
the mutation in the Iranian and four of the previously described FEO pedigrees was the same, haplotypes based on the intragenic
SNPs suggest that the mutations do not share a common descent. 相似文献
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Zamani F Shahram F Shakeri R Zayyeni H Davatchi F Amiri A Malekzadeh R 《Digestive diseases and sciences》2009,54(8):1736-1739
Background Behcet's disease and Celiac disease, both common in Iran, share many immunopathogenic and clinical features. Based on the
possible association between these two diseases, this study is designed to determine the frequency of non-diagnosed celiac
disease in patients with Behcet’s disease. Methods The sera of 288 consecutive patients with Behcet’s disease were screened with anti-endomysial antibody and anti-tissue transglutaminase
antibody for celiac disease. Those with a positive test underwent upper gastrointestinal endoscopy and duodenal biopsies to
confirm the diagnosis of celiac disease. The patients with celiac disease were put on a gluten free diet to evaluate its efficacy
on the improvement of their lesions. Results Fourteen patients had positive anti-tissue transglutaminase antibody test (two with positive anti-endomysial antibody as
well). Duodenal biopsies showed findings compatible with Marsh 3 in one and Marsh 1 in three other patients. All the diagnosed
patients with celiac disease responded to the gluten free diet. Conclusion Our findings didn’t support any association between celiac disease and Behcet’s disease in Iranian patients compared to the
general population of Iran. 相似文献
107.
Atusa Movasat Farhad Shahram Patricia E. Carreira Abdolhadi Nadji Maassoomeh Akhlaghi Nassim Naderi Fereydoun Davatchi 《Clinical rheumatology》2009,28(5):603-605
The aims of this study were to find the characteristics and prevalence of nailfold capillary changes in a large series of patients with Behçet’s disease (BD) and to analyze their possible relation to other clinical characteristics of the disease. We performed nailfold capillaroscopy in 128 randomly selected patients fulfilling the international classification criteria for BD. Capillaroscopy was done in eight fingers with a ×3.2 microscopy. All patients were questioned for history of Raynaud's phenomenon, ischemic ulcers, smoking, and hypertension. A computerized form including demographic, clinical, and para-clinical features was used to collect data. Univariate and multivariate logistic regressions were used to analyze the relation between capillaroscopic findings and disease characteristics. Odds ratio and a confidence interval at 95% (CI) were calculated for each item. The mean age of the patients was 37?±?10 years, and the male to female ratio was 1.56:1. Capillaroscopy was abnormal in 51 patients (40%, CI 8.5). Enlarged capillaries were seen in 33 patients (26%, CI 7.6), hemorrhages in 21 (16%, CI 6.4), and capillary loss only in one patient. In univariate logistic regression analysis, the presence of enlarged capillaries was associated with lower age at disease onset (OR?=?0.9, CI 0.9–1; p?=?0.04), hypertension (OR?=?4.2, CI 1.5–11.4; p?=?0.006), superficial phlebitis (OR?=?5.5, CI 1.2–24.4; p?=?0.03), and negative pathergy test (OR?=?0.4, CI 0.2–0.9; p?=?0.04). The presence of hemorrhages tended to be associated with articular symptoms (p?=?0.05). Multivariate analysis also confirmed the association of enlarged capillaries with lower age at disease onset (p?=?0.01), hypertension (p?=?0.001), and superficial phlebitis (p?=?0.03). Nailfold abnormalities, mainly enlarged capillaries, are frequent in patients with BD. Our results suggest that these abnormalities may be related to other vascular features of the disease such as superficial phlebitis, but it does not seem to confer special risk for any other specific clinical symptom of the disease. 相似文献
108.
Abdolali Moshfe Mehdi Mohebali Gholamhossein Edrissian Behnaz Akhoundi Shahram Jamshidi 《Acta tropica》2009,112(2):101-105
Clinically infected dogs have been identified as the main reservoir hosts of visceral leishmaniasis (VL) caused by Leishmania infantum in the Mediterranean region. The objective of this study was to determine the potential of asymptomatic infected dogs compared with symptomatic ones as a source of L. infantum infection to golden hamster.For this purpose, anti-Leishmania antibodies were detected with direct agglutination test (DAT) in 13 symptomatic (7 seropositive = ≥1:320) and 53 asymptomatic (9 seropositive = ≥1:320 and 44 seronegative = <1:320) ownership dogs. DNA of Leishmania sp. was extracted from skin and peripheral blood tissues of each dog and tested by PCR. Sixty-six Syrian golden hamsters (Mesocricetus auratus) were used for the determination of infectivity and pathogenicity of L. infantum, isolated from the dogs. We used the internal transcribed spacer 2 (ITS 2) rDNA sequence analysis. The results showed that 22 and 11 out of 66 inoculated golden hamsters were positive by PCR and parasitological examinations, respectively. From 22 PCR positive hamsters, 17 were related to asymptomatic dogs and 5 were from symptomatic ones. There was no significant difference between symptomatic and asymptomatic dogs in producing Leishmania infection in the susceptible animal model (P = 0.66). Smears and cultures of 5 dogs from 13 symptomatic dogs (38.5%) and 6 dogs from 53 asymptomatic ones (11.3%) were found to be positive at parasitological examination.All the L. infantum isolates from symptomatic and asymptomatic dogs were similar in sequencing.In conclusion, asymptomatic infected dogs as well as symptomatic ones can harbor L. infantum in their blood and skins which are virulent and infectious for inoculated golden hamster. 相似文献
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Today, the sinus floor elevation procedure is not only being used on a routine basis, but clinicians are reporting high success rates. The sinus floor graft has become an important option in the treatment of the edentulous posterior maxilla, where vertical bone height is less than ideal. A review of maxillary sinus floor elevation as an integral part of restoring the posterior maxillary is discussed. The related anatomy of the area and current osteotomy techniques are reviewed. This article describes a trephine osteotomy, which is an alternative technique to the existing lateral antrostomy approach currently being used. 相似文献